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Sleep duration, genetic susceptibility, and Alzheimer's disease: a longitudinal UK Biobank-based study
Yuan S, Ma W, Yang R, Xu F, Han D, Huang T, Peng M, Xu A et al.. BMC geriatrics, 2022-08-02
Topic: Amyloid, tau and blood-test diagnosis
Background Alzheimer's disease (AD) is the most frequently occurring type of dementia. Concurrently, inadequate sleep has been recognized as a public health epidemic. Notably, genetic and environmental factors are now considered contributors to AD progression.
Key findings
- Concurrently, inadequate sleep has been recognized as a public health epidemic.
- Notably, genetic and environmental factors are now considered contributors to AD progression.
- Objective To assess the association between sleep duration, genetic susceptibility, and AD.
- Methods and results Based on 483,507 participants from the UK Biobank (UKB) with an average follow-up of 11.3 years, there was a non-linear relationship between AD incidence and sleep duration (P for non-linear 9 h/night).
Why it matters
This UK Biobank study of 483,507 participants found a non-linear relationship between sleep duration and Alzheimer's disease incidence over an average 11.3 years of follow-up. It is an observational study, so it cannot show that changing sleep duration prevents Alzheimer's disease.
Study details
- Participants483,507
- Effect sizeHR = 3.4806
- Evidence strengthLow
How this study scored 54/100
Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (BMC geriatrics) |
| Journal's citation record | 2 / 4 | BMC Geriatrics: journal h-index 153 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 4 / 4 | 483,507 participants |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 49 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 8.2 citations a year over 6 year(s) since 2022 |
| Impact for its field and year | 3 / 6 | Cited 6.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 5 other studies in this library |
| Still being cited | 2 / 4 | Cited 40 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Jun Lyu: h-index 42 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Xi'an Jiaotong University: institution h-index 666 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35918656) |
| Free to read | 2 / 2 | Free to read |
| Total | 54 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Yuan, S., Ma, W., Yang, R., Xu, F., Han, D., Huang, T., et al. (2022). Sleep duration, genetic susceptibility, and Alzheimer's disease: a longitudinal UK Biobank-based study. BMC geriatrics. https://doi.org/10.1186/s12877-022-03298-8
Vancouver
Yuan S, Ma W, Yang R, Xu F, Han D, Huang T, et al. Sleep duration, genetic susceptibility, and Alzheimer's disease: a longitudinal UK Biobank-based study. BMC geriatrics. 2022. doi:10.1186/s12877-022-03298-8. PMID: 35918656.
BibTeX
@article{yuan2022-35918656,
author = {Yuan, S. and Ma, W. and Yang, R. and Xu, F. and Han, D. and Huang, T. and Peng, M. and Xu, A. and others},
title = {{Sleep duration, genetic susceptibility, and Alzheimer's disease: a longitudinal UK Biobank-based study}},
journal = {BMC geriatrics},
year = {2022},
doi = {10.1186/s12877-022-03298-8},
pmid = {35918656},
url = {https://doi.org/10.1186/s12877-022-03298-8}
}
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