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The Transcranial Light Therapy Improves Synaptic Plasticity in the Alzheimer's Disease Mouse Model
Débora Buendía, Tatiana Guncay, Macarena Oyanedel, Makarena Lemus, Alejandro Weinstein, Álvaro O Ardiles, José Marcos, Adriana Fernandes et al.. Brain sciences, 2022-09-21
Topic: Disease mechanisms in lab and animal studies
Alzheimer's disease (AD) is the main cause of dementia worldwide. Emerging non-invasive treatments such as photobiomodulation target the mitochondria to minimize brain damage, improving cognitive functions. In this work, an experimental design was carried out to evaluate the effect of transcranial light therapy (TLTC) on synaptic plasticity (SP) and cognitive functions in an AD animal model. Twenty-three mice were separated into two general groups: an APP/PS1 (ALZ) transgenic group and a wild-type (WT) group. Each group was randomly subdivided into two subgroups: mice with and without TLTC, depending on whether they would undergo treatment with TLTC. Cognitive function, measured through an object recognition task, showed non-significant improvement after TLTC. SP, on the other hand, was evaluated using four electrophysiological parameters from the Schaffer-CA1 collateral hippocampal synapses: excitatory field potentials (fEPSP), paired pulse facilitation (PPF), long-term depression (LTD), and long-term potentiation (LTP). An improvement was observed in subjects treated with TLTC, showing higher levels of LTP than those transgenic mice that were not exposed to the treatment. Therefore, the results obtained in this work showed that TLTC could be an efficient non-invasive treatment for AD-associated SP deficits.
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APA 7th
Buendía, D., Guncay, T., Oyanedel, M., Lemus, M., Weinstein, A., Ardiles, Á. O., et al. (2022). The Transcranial Light Therapy Improves Synaptic Plasticity in the Alzheimer's Disease Mouse Model. Brain sciences. https://doi.org/10.3390/brainsci12101272
Vancouver
Buendía D, Guncay T, Oyanedel M, Lemus M, Weinstein A, Ardiles ÁO, et al. The Transcranial Light Therapy Improves Synaptic Plasticity in the Alzheimer's Disease Mouse Model. Brain sciences. 2022. doi:10.3390/brainsci12101272. PMID: 36291206.
BibTeX
@article{buendia2022-36291206,
author = {Buendía, Débora and Guncay, Tatiana and Oyanedel, Macarena and Lemus, Makarena and Weinstein, Alejandro and Ardiles, Álvaro O and Marcos, José and Fernandes, Adriana and others},
title = {{The Transcranial Light Therapy Improves Synaptic Plasticity in the Alzheimer's Disease Mouse Model}},
journal = {Brain sciences},
year = {2022},
doi = {10.3390/brainsci12101272},
pmid = {36291206},
url = {https://doi.org/10.3390/brainsci12101272}
}
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Key findings
- Cognitive function, measured through an object recognition task, showed non-significant improvement after TLTC.
- Therefore, the results obtained in this work showed that TLTC could be an efficient non-invasive treatment for AD-associated SP deficits.
Study details
- Evidence strengthLow
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 23 of the 56 points we could judge it on, which is 41 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Brain sciences) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Laboratory or animal study (title names “mouse”) — scores zero |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 36291206) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 23 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 23 of the 56 points we could judge it on is 41 out of 100. |
| Total | 41 / 100 | — |
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