Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 8,201–8,225 of 27,380 studies, newest first · page 329 of 1096.
December 2022 25
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2022-12-08
Geospatial analysis of patients’ social determinants of health for health systems science and disparity research
45/100 ✓ Peer-reviewed Risk factors International Anesthesiology Clinics
Key finding: The cross-disciplinary expertise, required for GA, common in the days before medical specialization and enabled by the relative paucity of development in various fields compared with today, can be reborn with the advent of Electronic Health Records (EHR) systems that make the tools of medical geography accessible to a wide variety of health care researchers and clinical subspecialties. +3 more findings
Full summary, score breakdown and related studies → Original source
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2022-12-07
Brain vitamin D forms, cognitive decline, and neuropathology in community-dwelling older adults
54/100 ✓ Peer-reviewed Prevention and risk Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: The main form of vitamin D in all brain regions measured was 25(OH)D3 . +4 more findings
Full summary, score breakdown and related studies → Original source
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2022-12-07
Metformin: new applications for an old drug
41/100 ✓ Peer-reviewed Drug development Journal of basic and clinical physiology and pharmacology
Key finding: Concerning renal function, studies showed that daily oral administration of metformin could ameliorate kidney fibrosis and normalize kidney structure and function.
Full summary, score breakdown and related studies → Original source
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2022-12-07
Quantification of [18 F]florbetaben amyloid-PET imaging in a mixed memory clinic population: The ABIDE project
70/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: CL was associated with syndromic (F = 4.42, p = 0.014) and etiological diagnosis (F = -12.66, p < 0.001), with Alzheimer's disease (AD) patients showing the highest amyloid burden (62.9 ± 27.5), followed by dementia with Lewy bodies (DLB) (25.3 ± 35.5) and cardiovascular disease (CVD) (16.7 ± 24.5), and finally frontotemporal lobe degeneration (FTLD) (5.0 ± 17.22, t = -12.66, p < 0.001). +3 more findings
Full summary, score breakdown and related studies → Original source
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2022-12-07
Validation of a novel computerized cognitive function test for the rapid detection of mild cognitive impairment
48/100 ✓ Peer-reviewed Cognitive tests and assessment BMC neurology
Key finding: The median (interquartile range) test time for MARC was 401 (350-453) s. +4 more findings
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2022-12-07
A Randomized Control Trial for ReDeSign: A Dementia-Friendly Mobile Microlearning Training for Store Workers in Japan
48/100 ✓ Peer-reviewed Risk factors The Gerontologist
Key finding: Process evaluations confirmed satisfaction and high completion rates of the program. +4 more findings
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2022-12-07
Association between multimorbidity status and incident dementia: a prospective cohort study of 245,483 participants
49/100 ✓ Peer-reviewed Long-term cohort studies Translational psychiatry
Key finding: The impact of multimorbidity on dementia has not been fully elucidated. +3 more findings
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2022-12-07
Platinum-Based TREM2 Inhibitor Suppresses Tumors by Remodeling the Immunosuppressive Microenvironment
45/100 ✓ Peer-reviewed TREM2 and immune genetics Angewandte Chemie (International ed. in English)
Key finding: A platinum(IV) complex OPA derived from oxaliplatin (OP) and artesunate (ART) exhibited direct cytotoxicity against human colon cancer cells and immunomodulatory activity to inhibit TREM2 on macrophages in vitro and vivo. +2 more findings
Full summary, score breakdown and related studies → Original source
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2022-12-06
TREM2 R47H variant and risk for Alzheimer's disease: assessment in a Greek population and updated meta-analysis
70/100 ✓ Peer-reviewed TREM2 and immune genetics The International journal of neuroscience
Key finding: The rs75932628 was associated with AD in the Greek sample. +4 more findings
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2022-12-05
Racial/ethnic disparities in dementia incidence, outcomes, and health-care utilization
45/100 ✓ Peer-reviewed Disparities Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Disparities in incidence of NDD between Black and White beneficiaries narrowed by 0.37 per 100 person-years from 2014 to 2017. +4 more findings
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2022-12-05
MRI-Visible Perivascular Spaces and Risk of Incident Dementia: The Framingham Heart Study
56/100 ✓ Peer-reviewed Long-term cohort studies Neurology
Key finding: Perivascular spaces (PVS) visible on MRI scans may represent key aspects in the pathophysiology of stroke and dementia, including cerebral small vessel disease and glymphatic dysfunction. +3 more findings
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2022-12-05
The cost of inaction on physical inactivity to public health-care systems: a population-attributable fraction analysis
53/100 ✓ Peer-reviewed Caregiving The Lancet. Global health
Key finding: 499·2 million new cases of preventable major NCDs would occur globally by 2030 if the prevalence of physical inactivity does not change, with direct health-care costs of INT$520 billion.
Full summary, score breakdown and related studies → Original source
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2022-12-05
Association of Data-Driven White Matter Hyperintensity Spatial Signatures With Distinct Cerebral Small Vessel Disease Etiologies
58/100 ✓ Peer-reviewed Biomarkers Neurology
Key finding: Data-driven WMH spatial patterns reflect discrete underlying etiologies including arteriolosclerosis, CAA, AD, and normal aging. +3 more findings
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2022-12-04
TDP-43 pathology effect on volume and flortaucipir uptake in Alzheimer's disease
48/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Older participants had lower hippocampal volumes and overall flortaucipir uptake. +4 more findings
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2022-12-04
Whole-exome rare-variant analysis of Alzheimer's disease and related biomarker traits
54/100 ✓ Peer-reviewed Genetics Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Mutation screening revealed a novel probably pathogenic mutation (PSEN1 p.Leu232Phe). +2 more findings
Full summary, score breakdown and related studies → Original source
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2022-12-03
Is plasma amyloid-β 1-42/1-40 a better biomarker for Alzheimer's disease than AβX-42/X-40?
45/100 ✓ Peer-reviewed Biomarkers Fluids and barriers of the CNS
Key finding: The median Aβ1-42/1-40 ratio was 20.86% lower in amyloid-positive subjects than in the amyloid-negative group, while the median AβX-42/X-40 ratio was only 15.56% lower. +4 more findings
Full summary, score breakdown and related studies → Original source
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2022-12-03
TREM2 activation alleviates neural damage via Akt/CREB/BDNF signalling after traumatic brain injury in mice
48/100 ✓ Peer-reviewed TREM2 and immune genetics Journal of neuroinflammation
Key finding: Neuroinflammation is one of the most important processes in secondary injury after traumatic brain injury (TBI). +3 more findings
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2022-12-02
Advance Care Planning Among Adult Patients and Their End-of-Life Care Preferences
61/100 ✓ Peer-reviewed End-of-life care Omega
Key finding: This study revealed the following two results.
Full summary, score breakdown and related studies → Original source
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2022-12-02
Amyloid β-Peptide Causes the Permanent Activation of CaMKIIα through Its Oxidation
41/100 ✓ Peer-reviewed Disease mechanisms International journal of molecular sciences
Key finding: We found that oAβ produce reactive oxygen species (ROS), that induce CaMKIIα oxidation in human neuroblastoma cells as we assayed by western blot and immunofluorescence. +4 more findings
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2022-12-02
Effects of Kami Guibi-tang in patients with mild cognitive impairment: study protocol for a phase III, randomized, double-blind, and placebo-controlled trial
59/100 ✓ Peer-reviewed Clinical trials BMC complementary medicine and therapies
Key finding: This study aims to provide confirmatory evidence of the effect of the Korean herbal medicine, KGT, on improving cognitive function in patients with aMCI. +2 more findings
Full summary, score breakdown and related studies → Original source
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2022-12-02
Alternative role of glucagon-like Peptide-1 receptor agonists in neurodegenerative diseases
41/100 ✓ Peer-reviewed Drug development European journal of pharmacology
Key finding: Limited options are available for the treatment of age-related, multiple pathogenic mechanism-contributed diseases that usually advance to irreversible conditions with severe neurological deficits and result in a heavy socioeconomic burden on patients, families, and society.
Full summary, score breakdown and related studies → Original source
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2022-12-02
Comparing ARIA-E severity scales and effects of treatment management thresholds
52/100 ✓ Peer-reviewed Treatments Alzheimer's & dementia (Amsterdam, Netherlands)
Key finding: SSAE-3/5 scores correlated with BGTS scores, with high inter-reader intraclass correlation coefficients across all scales. +2 more findings
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2022-12 month only
Usability and acceptability of wearable technology in the early detection of dementia
45/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Sixteen semi-structured interviews were conducted with nine participants, at two-time points. +4 more findings
Full summary, score breakdown and related studies → Original source
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2022-12-01
Plasma neurofilament light chain in memory clinic practice: Evidence from a real-life study
66/100 ✓ Peer-reviewed Biomarkers Neurobiology of disease
Key finding: (N = 558, mean age = 69.2 ± 8.8, 56.5% women) were diagnosed with AD (n = 274, considering dementia and MCI stages), frontotemporal dementia (FTD, n = 55), Lewy body disease (LBD, n = 40, considering MCI and dementia stages), other neurodegenerative diseases, n = 57 (e.g Supranuclear Palsy, Corticobasal syndrome), non-neurodegenerative cognitive impairment (NND, n = 79, e.g. vascular lesions, epilepsy or psychiatric disorders) or subjective cognitive impairment (SCI, n = 53). +3 more findings
Full summary, score breakdown and related studies → Original source
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2022-12-01
Spatial proteomics in three-dimensional intact specimens
40/100 ✓ Peer-reviewed Digital health tools Cell
Key finding: Here, we present DISCO-MS, a technology that combines whole-organ/whole-organism clearing and imaging, deep-learning-based image analysis, robotic tissue extraction, and ultra-high-sensitivity mass spectrometry. +4 more findings
Full summary, score breakdown and related studies → Original source
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