Newest studies

Automatic Segmentation of Retinal Layers in Multiple Neurodegenerative Disorder Scenarios

41/100 ✓ Peer-reviewed Brain scans and imaging IEEE journal of biomedical and health informatics

Key finding: The results show that images of healthy patients may not be sufficient for the robust training of automated segmentation models intended for the analysis of ND patients, and that using images representative of different NDs can increase the model performance. +1 more finding

Full summary, score breakdown and related studies → Original source

Multiple sclerosis

47/100 ✓ Peer-reviewed Mild cognitive impairment Lancet (London, England)

Key finding: Improvements in diagnostic criteria, harmonised guidelines for MRI, and globalised treatment recommendations have led to more accurate diagnosis and an earlier start of effective immunomodulatory treatment than previously. +4 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Perceptions of Hospital Care for Persons With Dementia During the COVID-19 Pandemic: A Social Media Sentiment Analysis

35/100 ✓ Peer-reviewed Health systems and care delivery The Gerontologist

Key finding: Hospital dementia care discourse on Reddit advanced 4 negative sentiment themes: (1) fear of poor medication management, hydration, and hygiene, (2) loss of patient advocacy, (3) precipitation of advance directive discussions, and (4) delayed discharge and loss of nursing home bed. +4 more findings

• Care Services

Full summary, score breakdown and related studies → Original source

Menopausal vasomotor symptoms and plasma Alzheimer disease biomarkers

50/100 ✓ Peer-reviewed Biomarkers American journal of obstetrics and gynecology

Key finding: Nighttime vasomotor symptoms may be a marker of women at risk of Alzheimer disease. +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Quantitative estimate of cognitive resilience and its medical and genetic associations

54/100 ✓ Peer-reviewed Risk factors Alzheimer's research & therapy

Key finding: CR varied across five cognitive assessments and was greater in female participants, associated with longer survival, and weakly associated with educational attainment or APOE ε4 allele. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

The Impact of Pandemic-Related Restrictions on Dementia Risk Factors in Older Adults

84/100 ✓ Peer-reviewed Prevention trials Journal of applied gerontology : the official journal of the Southern Gerontological Society

Key finding: The data show a significant decline in social activity, physical activity, and mood among respondents. +2 more findings

• Clinical Trials
• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

Correlation studies of Hippocampal Morphometry and Plasma NFL Levels in Cognitively Unimpaired Subjects

45/100 ✓ Peer-reviewed Biomarkers IEEE transactions on computational social systems

Key finding: Experimental results show that the proposed hippocampal morphometry system offers stronger statistical power to discriminate CU subjects with NFL+ and NFL- levels, comparing with the hippocampal volume measure. +1 more finding

• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source

Vascular risk, gait, behavioral, and plasma indicators of VCID

55/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: VRFs and gait were associated with diffusion changes even in low age strata. +4 more findings

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Plasma Aβ42/Aβ40 and phospho-tau217 concentration ratios increase the accuracy of amyloid PET classification in preclinical Alzheimer's disease

45/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Including plasma p-tau217/np-tau217 along with Aβ42/Aβ40 in predictive algorithms may streamline screening preclinical individuals into anti-amyloid clinical trials. +1 more finding

• Biomarkers
• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Integrative multi-omic profiling of adult mouse brain endothelial cells and potential implications in Alzheimer's disease

41/100 ✓ Peer-reviewed Genetics Cell reports

Key finding: Overall, we present a valuable resource with broad implications for regulation of the BBB and treatment of neurological disorders.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Explainable variational autoencoder (E-VAE) model using genome-wide SNPs to predict dementia

54/100 ✓ Peer-reviewed Genetics Journal of biomedical informatics

Key finding: We obtained a predictive accuracy of 0.71 (95 % CI [0.59, 0.84]) with an AUC of 0.69 in the HRS test dataset and got an accuracy of 0.62 (95 % CI [0.56, 0.68]) with an AUC of 0.63 in the ROSMAP dataset. +2 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Role of trigger receptor 2 expressed on myeloid cells in neuroinflammation－neglected multidimensional regulation of microglia

41/100 ✓ Peer-reviewed TREM2 and immune genetics Neurochemistry international

Key finding: While TREM2 is initially believed to be an anti-inflammatory factor in the CNS, increasing evidence suggests that TREM2 plays a more complex role in balancing neuroinflammation. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Proteostasis and neurodegeneration: a closer look at autophagy in Alzheimer's disease

41/100 ✓ Peer-reviewed Disease mechanisms Frontiers in aging neuroscience

Key finding: This review examines the impact of impaired autophagy on the progression of AD disease pathology. +4 more findings

• Brain Biology
• Treatments

Full summary, score breakdown and related studies → Original source

Genetic risk scores enhance the diagnostic value of plasma biomarkers of brain amyloidosis

54/100 ✓ Peer-reviewed Genetics Brain : a journal of neurology

Key finding: Analysing 962 individuals from a population-based sample, we observed that an AD-GRS was independently associated with amyloid PET levels (an early marker of AD pathophysiology) over and above APOE ε4 or plasma p-tau181, amyloid-β42/40, glial fibrillary acidic protein or neurofilament light chain. +2 more findings

• Biomarkers
• Genetics
• Diagnosis

Full summary, score breakdown and related studies → Original source

TREM2 Deficiency Aggravates NLRP3 Inflammasome Activation and Pyroptosis in MPTP-Induced Parkinson's Disease Mice and LPS-Induced BV2 Cells

50/100 ✓ Peer-reviewed TREM2 and immune genetics Molecular neurobiology

Key finding: Triggering receptor expressed on myeloid cells 2 (TREM2) confers strong neuroprotective effects in PD by regulating the phenotype of microglia. +3 more findings

• Genetics
• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Racial Differences in Clinical Presentation in Individuals Diagnosed With Frontotemporal Dementia

66/100 ✓ Peer-reviewed Disparities JAMA neurology

Key finding: The final sample comprised 2478 individuals, of which 59 (2.4%) were Asian, 63 (2.5%) were Black, and 2356 (95.1%) were White. +4 more findings

• Health Equity
• Other Dementias

Full summary, score breakdown and related studies → Original source

Molecular genetics of neuropsychiatric illness: some musings

41/100 ✓ Peer-reviewed Genetics Frontiers in genetics

Key finding: Even so, the results of studies on well-characterised clinical datasets of modest sizes can be enlightening and provide important clues to understanding these complex disorders.

• Genetics

Full summary, score breakdown and related studies → Original source

Amyloid-related imaging abnormalities (ARIA): radiological, biological and clinical characteristics

53/100 ✓ Peer-reviewed Treatments Brain : a journal of neurology

Key finding: This review provides a comprehensive state-of-the-art conceptual review of radiological features, clinical detection and classification challenges, pathophysiology, underlying biological mechanism(s) and risk factors/predictors associated with ARIA. +1 more finding

• Side Effects

Full summary, score breakdown and related studies → Original source

Peripherin is a biomarker of axonal damage in peripheral nervous system disease

69/100 ✓ Peer-reviewed Biomarkers Brain : a journal of neurology

Key finding: We demonstrated that peripherin is distributed in sciatic nerve, and to a lesser extent spinal cord tissue lysates, but not in brain or extra-neural tissues. +2 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Factors associated with delayed treatment initiation of oral anticoagulants among Medicare patients with atrial fibrillation

41/100 ✓ Peer-reviewed Health systems and care delivery European Heart Journal

Key finding: In this study on Medicare patients with AF, Black race, low-income subsidy, and dual eligibility were found to be associated with delayed OAC initiation, suggesting potential disparities in the care of AF with timely OAC treatment. +4 more findings

• Policy
• Treatments

Full summary, score breakdown and related studies → Original source

Monitoring and Evaluation of Dementia-Friendly Neighborhoods Using a Walkshed Approach: Protocol for a Scoping Review

45/100 ✓ Peer-reviewed Health systems and care delivery JMIR Research Protocols

Key finding: The results of the study and the submission of a manuscript for peer review are expected in June 2024. +4 more findings

Full summary, score breakdown and related studies → Original source

Association of medication adherence quality measures for diabetes, hypertension, and hyperlipidemia with cognitive decline

40/100 ✓ Peer-reviewed Health systems and care delivery Journal of Family Medicine and Primary Care

Key finding: The study population of 99,774 individuals had a mean age of 71.0 years and was 49.1% female, 73.9% White, and 17.8% Black, with 62.0% living in an urban setting. +4 more findings

• Risk Factors
• Treatments

Full summary, score breakdown and related studies → Original source

Age at Diagnosis of Atrial Fibrillation and Incident Dementia

66/100 ✓ Peer-reviewed Long-term cohort studies JAMA network open

Key finding: Epidemiological evidence regarding the association between atrial fibrillation (AF) onset age and risk of incident dementia remains unexplored. +3 more findings

• Diagnosis
• Risk Factors

Full summary, score breakdown and related studies → Original source

Alzheimer Disease Biomarkers: Moving from CSF to Plasma for Reliable Detection of Amyloid and tau Pathology

49/100 ✓ Peer-reviewed Tau biomarkers Clinical chemistry

Key finding: Development of validated biomarkers to detect early Alzheimer disease (AD) neuropathology is needed for therapeutic AD trials. +3 more findings

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

Stimulation of TREM2 with agonistic antibodies-an emerging therapeutic option for Alzheimer's disease

54/100 ✓ Peer-reviewed TREM2 and immune genetics The Lancet. Neurology

Key finding: Microglia have long been considered to have detrimental roles in Alzheimer's disease. +3 more findings

• Genetics

Full summary, score breakdown and related studies → Original source