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Antiplatelets and Vascular Dementia: A Systematic Review
Peter Alexander, Shakthi Visagan, Sara Jawhar, Amogh Kare, Noor Issa, Reem Issa, Abbas Jawhar, Sneha Thomas et al.. Journal of aging research, 2022-09-19
Topic: Drug trials: efficacy and safety
Vascular dementia (VD) is a neurocognitive disorder whose precise definition is still up for debate. VD generally refers to dementia that is primarily caused by cerebrovascular disease or impaired cerebral blood flow. It is a subset of vascular cognitive impairment, a class of diseases that relate any cerebrovascular injury as a causal or correlating factor for cognitive decline, most commonly seen in the elderly. Patients who present with both cognitive impairment and clinical or radiologic indications of cerebrovascular pathology should have vascular risk factors, particularly hypertension, examined and treated. While these strategies may be more effective at avoiding dementia than at ameliorating it, there is a compelling case for intensive secondary stroke prevention in these patients. Repeated stroke is related to an increased chance of cognitive decline, and poststroke dementia is connected with an increased risk of death. In general, most physicians follow recommendations for secondary stroke prevention in patients with VD, which can be accomplished by the use of antithrombotic medicines such as antiplatelets (aspirin, clopidogrel, ticlopidine, cilostazol, etc.). In individuals with a high risk of atherosclerosis and those with documented symptomatic cerebrovascular illness, antiplatelets treatment lowers the risk of stroke. While this therapy strategy of prevention and rigorous risk management has a compelling justification, there is only limited and indirect data to support it. The following systematic review examines the role of antiplatelets in the management of vascular dementia in published clinical trials and studies and comments on the current evidence available to support their use and highlights the need for further study.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Alexander, P., Visagan, S., Jawhar, S., Kare, A., Issa, N., Issa, R., et al. (2022). Antiplatelets and Vascular Dementia: A Systematic Review. Journal of aging research. https://doi.org/10.1155/2022/9780067
Vancouver
Alexander P, Visagan S, Jawhar S, Kare A, Issa N, Issa R, et al. Antiplatelets and Vascular Dementia: A Systematic Review. Journal of aging research. 2022. doi:10.1155/2022/9780067. PMID: 36245899.
BibTeX
@article{alexander2022-36245899,
author = {Alexander, Peter and Visagan, Shakthi and Jawhar, Sara and Kare, Amogh and Issa, Noor and Issa, Reem and Jawhar, Abbas and Thomas, Sneha and others},
title = {{Antiplatelets and Vascular Dementia: A Systematic Review}},
journal = {Journal of aging research},
year = {2022},
doi = {10.1155/2022/9780067},
pmid = {36245899},
url = {https://doi.org/10.1155/2022/9780067}
}
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Key findings
- Repeated stroke is related to an increased chance of cognitive decline, and poststroke dementia is connected with an increased risk of death.
Study details
- Study designsystematic review
- Evidence strengthHigh
How this study scored 70/100
Published in a peer-reviewed journal, and it is a systematic review of all the studies on the question. Scored zero for sample size, effect reported and studied in people because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 39 of the 56 points we could judge it on, which is 70 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of aging research) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 12 / 12 | A systematic review of all the studies on the question |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | A review of other studies — randomisation is not credited here |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 36245899) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 39 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 39 of the 56 points we could judge it on is 70 out of 100. |
| Total | 70 / 100 | — |
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