Home › Research › Long-term cohort studies
Association between multimorbidity status and incident dementia: a prospective cohort study of 245,483 participants
Hu HY, Zhang YR, Aerqin Q, Ou YN, Wang ZT, Cheng W, Feng JF, Tan L et al.. Translational psychiatry, 2022-12-07
Topic: Risk, prevention and care in population studies
Multimorbidity (the presence of two or more long-term conditions [LTCs]) was suggested to exacerbate the neuronal injuries. The impact of multimorbidity on dementia has not been fully elucidated. We aimed to investigate the association between multimorbidity and dementia risk.
Key findings
- The impact of multimorbidity on dementia has not been fully elucidated.
- We aimed to investigate the association between multimorbidity and dementia risk.
- We used the prospective data from 245,483 UK Biobank participants during a 9-year follow-up.
- Multimorbidity status was evaluated based on the LTC counts and multimorbidity patterns.
Why it matters
This large prospective study looked at whether having two or more long-term health conditions is linked to a higher risk of dementia. It does not show that treating those conditions prevents dementia, only that an association was found.
Study details
- Effect sizeHR = 1.18; HR = 1.65; HR = 2.10
- Evidence strengthLow
How this study scored 49/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Translational psychiatry) |
| Journal's citation record | 2 / 4 | Translational Psychiatry: journal h-index 180 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 51 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 8.5 citations a year over 6 year(s) since 2022 |
| Impact for its field and year | 3 / 6 | Cited 6.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 4 other studies in this library |
| Still being cited | 2 / 4 | Cited 46 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Jin‐Tai Yu: h-index 39 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Fudan University: institution h-index 954 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 7 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 36476644) |
| Free to read | 2 / 2 | Free to read |
| Total | 49 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1038/s41398-022-02268-3
- PubMed: 36476644
- Original source →
- Free full text: Translational Psychiatry →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Hu, H. Y., Zhang, Y. R., Aerqin, Q., Ou, Y. N., Wang, Z. T., Cheng, W., et al. (2022). Association between multimorbidity status and incident dementia: a prospective cohort study of 245,483 participants. Translational psychiatry. https://doi.org/10.1038/s41398-022-02268-3
Vancouver
Hu HY, Zhang YR, Aerqin Q, Ou YN, Wang ZT, Cheng W, et al. Association between multimorbidity status and incident dementia: a prospective cohort study of 245,483 participants. Translational psychiatry. 2022. doi:10.1038/s41398-022-02268-3. PMID: 36476644.
BibTeX
@article{hu2022-36476644,
author = {Hu, H. Y. and Zhang, Y. R. and Aerqin, Q. and Ou, Y. N. and Wang, Z. T. and Cheng, W. and Feng, J. F. and Tan, L. and others},
title = {{Association between multimorbidity status and incident dementia: a prospective cohort study of 245,483 participants}},
journal = {Translational psychiatry},
year = {2022},
doi = {10.1038/s41398-022-02268-3},
pmid = {36476644},
url = {https://doi.org/10.1038/s41398-022-02268-3}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here. Showing 12 of 18.
Later studies that cite this one
4 studies in the alzhub library list this one in their references.
Related studies in Long-term cohort studies
Also tagged “biobank”
1,084 studies in the library carry the topic tag “biobank”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 1,084 tagged studies.