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Comparing ARIA-E severity scales and effects of treatment management thresholds
Gregory Klein, Marzia A Scelsi, Jerome Barakos, Jochen B Fiebach, Luc Bracoud, Joyce Suhy, Paul Delmar, Marco Lyons et al.. Alzheimer's & dementia (Amsterdam, Netherlands), 2022-12-02
Topic: Drug trials: efficacy and safety
SSAE-3/5 scores correlated with BGTS scores, with high inter-reader intraclass correlation coefficients across all scales. There was high agreement in dichotomized ratings for SSAE-3 > 1 versus BGTS > 3 for all readers (accuracy 0.85-0.93) and between pairs of readers. SSAE-3/5 showed high degrees of correlation with BGTS, potentially allowing seamless transition from the BGTS to SSAE-3/5 for ARIA-E management.
Key findings
- SSAE-3/5 scores correlated with BGTS scores, with high inter-reader intraclass correlation coefficients across all scales.
- There was high agreement in dichotomized ratings for SSAE-3 > 1 versus BGTS > 3 for all readers (accuracy 0.85-0.93) and between pairs of readers.
- SSAE-3/5 showed high degrees of correlation with BGTS, potentially allowing seamless transition from the BGTS to SSAE-3/5 for ARIA-E management.
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Study details
- Participants75
- Evidence strengthLow
How this study scored 52/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 29 of the 56 points we could judge it on, which is 52 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia (Amsterdam, Netherlands)) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 1 / 4 | 75 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 36474747) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 29 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 29 of the 56 points we could judge it on is 52 out of 100. |
| Total | 52 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Klein, G., Scelsi, M. A., Barakos, J., Fiebach, J. B., Bracoud, L., Suhy, J., et al. (2022). Comparing ARIA-E severity scales and effects of treatment management thresholds. Alzheimer's & dementia (Amsterdam, Netherlands). https://doi.org/10.1002/dad2.12376
Vancouver
Klein G, Scelsi MA, Barakos J, Fiebach JB, Bracoud L, Suhy J, et al. Comparing ARIA-E severity scales and effects of treatment management thresholds. Alzheimer's & dementia (Amsterdam, Netherlands). 2022. doi:10.1002/dad2.12376. PMID: 36474747.
BibTeX
@article{klein2022-36474747,
author = {Klein, Gregory and Scelsi, Marzia A and Barakos, Jerome and Fiebach, Jochen B and Bracoud, Luc and Suhy, Joyce and Delmar, Paul and Lyons, Marco and others},
title = {{Comparing ARIA-E severity scales and effects of treatment management thresholds}},
journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
year = {2022},
doi = {10.1002/dad2.12376},
pmid = {36474747},
url = {https://doi.org/10.1002/dad2.12376}
}
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