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54/100

✓ Peer-reviewed alzhub usefulness score 54 out of 100. Prevention and risk

Topic: Brain imaging, connectivity and assessment

The main form of vitamin D in all brain regions measured was 25(OH)D3 . Higher brain 25(OH)D3 concentrations were associated with a 25% to 33% lower odds of dementia or mild cognitive impairment (MCI) at the last visit before death (all P ≤ .031). However, brain 25(OH)D concentrations were not associated with any post-mortem neuropathology outcome studied. Higher brain 25(OH)D3 concentrations were associated with better cognitive function prior to death. Additional research is needed to clarify the specific mechanisms underlying this potentially protective relationship.

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APA 7th

Shea, M. K., Barger, K., Dawson-Hughes, B., Leurgans, S. E., Fu, X., James, B. D., et al. (2023). Brain vitamin D forms, cognitive decline, and neuropathology in community-dwelling older adults. Alzheimer's & dementia : the journal of the Alzheimer's Association. https://doi.org/10.1002/alz.12836

Vancouver

Shea MK, Barger K, Dawson-Hughes B, Leurgans SE, Fu X, James BD, et al. Brain vitamin D forms, cognitive decline, and neuropathology in community-dwelling older adults. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023. doi:10.1002/alz.12836. PMID: 36479814.

BibTeX

@article{shea2023-36479814,
  author  = {Shea, M Kyla and Barger, Kathryn and Dawson-Hughes, Bess and Leurgans, Sue E and Fu, Xueyan and James, Bryan D and Holland, Thomas M and Agarwal, Puja and others},
  title   = {{Brain vitamin D forms, cognitive decline, and neuropathology in community-dwelling older adults}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2023},
  doi     = {10.1002/alz.12836},
  pmid    = {36479814},
  url     = {https://doi.org/10.1002/alz.12836}
}

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Key findings

The main form of vitamin D in all brain regions measured was 25(OH)D3 .
Higher brain 25(OH)D3 concentrations were associated with a 25% to 33% lower odds of dementia or mild cognitive impairment (MCI) at the last visit before death (all P ≤ .031).
However, brain 25(OH)D concentrations were not associated with any post-mortem neuropathology outcome studied.
Higher brain 25(OH)D3 concentrations were associated with better cognitive function prior to death.
Additional research is needed to clarify the specific mechanisms underlying this potentially protective relationship.

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Study details

Participants290
Evidence strengthLow

How this study scored 54/100

Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 30 of the 56 points we could judge it on, which is 54 out of 100.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (Alzheimer's & dementia : the journal of the Alzheimer's Association)
Journal's citation record	— / 4	No journal record from OpenAlex — left out of this score
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	3 / 5	2023 — within 6 year(s) of the newest study here
Sample size	2 / 4	290 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	— / 7	No citation count (not found in OpenAlex) — left out of this score
Citations per year	— / 5	No citation count or no year — left out of this score
Impact for its field and year	— / 6	No field-weighted citation impact (OpenAlex has none yet) — left out of this score
Cited by studies here	— / 6	Not yet checked against this library's citation graph — left out of this score
Still being cited	— / 4	No yearly citation counts — left out of this score
Senior author's track record	— / 4	Senior author's record not available — left out of this score
Institution's track record	— / 3	No institution listed in OpenAlex — left out of this score
Multi-centre collaboration	— / 3	Institutions not listed — left out of this score
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 36479814)
Free to read	— / 2	Access not recorded — left out of this score
Points	30 / 56	Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 30 of the 56 points we could judge it on is 54 out of 100.
Total	54 / 100	—

What each of these 20 components measures, and what this score is not →

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