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TREM2 Regulates the Removal of Apoptotic Cells and Inflammatory Processes during the Progression of NAFLD
Liebold I, Meyer S, Heine M, Kuhl A, Witt J, Eissing L, Fischer AW, Koop AC et al.. Cells, 2023-01-17
Topic: Brain proteins, microglia and lab models
Nonalcoholic fatty liver disease (NAFLD) is the most common liver pathology worldwide. In mice and humans, NAFLD progression is characterized by the appearance of TREM2-expressing macrophages in the liver. However, their mechanistic contributions to disease progression have not been completely elucidated.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Liebold, I., Meyer, S., Heine, M., Kuhl, A., Witt, J., Eissing, L., et al. (2023). TREM2 Regulates the Removal of Apoptotic Cells and Inflammatory Processes during the Progression of NAFLD. Cells. https://doi.org/10.3390/cells12030341
Vancouver
Liebold I, Meyer S, Heine M, Kuhl A, Witt J, Eissing L, et al. TREM2 Regulates the Removal of Apoptotic Cells and Inflammatory Processes during the Progression of NAFLD. Cells. 2023. doi:10.3390/cells12030341. PMID: 36766683.
BibTeX
@article{liebold2023-36766683,
author = {Liebold, I. and Meyer, S. and Heine, M. and Kuhl, A. and Witt, J. and Eissing, L. and Fischer, A. W. and Koop, A. C. and others},
title = {{TREM2 Regulates the Removal of Apoptotic Cells and Inflammatory Processes during the Progression of NAFLD}},
journal = {Cells},
year = {2023},
doi = {10.3390/cells12030341},
pmid = {36766683},
url = {https://doi.org/10.3390/cells12030341}
}
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Key findings
- In mice and humans, NAFLD progression is characterized by the appearance of TREM2-expressing macrophages in the liver.
- However, their mechanistic contributions to disease progression have not been completely elucidated.
- Here, we show that TREM2 + macrophages prevent the generation of a pro-inflammatory response elicited by LPS-laden lipoproteins in vitro .
- Further, Trem2 expression regulates bone-marrow-derived macrophages (BMDMs) and Kupffer cell capacity to phagocyte apoptotic cells in vitro , which is dependent on CD14 activation.
Why it matters
In this study of nonalcoholic fatty liver disease, TREM2-positive macrophages prevented a pro-inflammatory response in vitro and Trem2 expression regulated the ability of macrophages to phagocytose apoptotic cells. This is a liver disease study, so it does not provide evidence about treating, curing or preventing Alzheimer's disease.
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Study details
- Evidence strengthModerate
How this study scored 49/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Cells) |
| Journal's citation record | 2 / 4 | Cells: journal h-index 234 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 54 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 10.8 citations a year over 5 year(s) since 2023 |
| Impact for its field and year | 4 / 6 | Cited 9.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 3 / 4 | Cited 50 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Anna Worthmann: h-index 19 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 36766683) |
| Free to read | 2 / 2 | Free to read |
| Total | 49 / 100 | — |
What each of these 20 components measures, and what this score is not →
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