Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 10,526–10,550 of 27,380 studies, newest first · page 422 of 1096.
February 2021 25
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2021-02-17
Caregiver identity in care partners of persons living with mild cognitive impairment
48/100 ✓ Peer-reviewed Caregiving Dementia (London, England)
Key finding: These themes influenced how participants primarily identified, represented as I am a caregiver, I am not a caregiver, or liminality (i.e., between their previous identity and a caregiver identity). +4 more findings
Full summary, score breakdown and related studies → Original source
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2021-02-17
Small Area Estimation under Spatial Multivariate Fay--Herriot Model
28/100 ✓ Peer-reviewed Risk factors Not indexed
Key finding: The empirical results clearly show that the proposed small area predictor outperforms the existing predictors.
Full summary, score breakdown and related studies → Original source
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2021-02-17
Small Area Estimation under Spatial Multivariate Fay–Herriot Model
28/100 ✓ Peer-reviewed Risk factors Not indexed
Key finding: The empirical results clearly show that the proposed small area predictor outperforms the existing predictors.
Full summary, score breakdown and related studies → Original source
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2021-02-17
Neighborhood Sidewalk Environment and Incidence of Dementia in Older Japanese Adults
59/100 ✓ Peer-reviewed Risk factors American Journal of Epidemiology
Key finding: In urban areas, compared with the lowest quartile of sidewalk coverage, the hazard ratio was 0.42 (95% confidence interval: 0.33, 0.54) for the highest quartile, adjusting for individual covariates. +2 more findings
Full summary, score breakdown and related studies → Original source
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2021-02-17
Iron loading is a prominent feature of activated microglia in Alzheimer's disease patients
48/100 ✓ Peer-reviewed Inflammation and the immune system Acta neuropathologica communications
Key finding: Microglia have been identified as key players in the disease pathogenesis, and are highly reactive cells responding to aberrations such as increased iron levels. +3 more findings
Full summary, score breakdown and related studies → Original source
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2021-02-17
Systematic Pan-Cancer Analysis Identifies TREM2 as an Immunological and Prognostic Biomarker
44/100 ✓ Peer-reviewed TREM2 and immune genetics Frontiers in immunology
Key finding: Although increasing evidence supports a vital role for TREM2 in tumorigenesis of some cancers, no systematic pan-cancer analysis of TREM2 is available. +3 more findings
Full summary, score breakdown and related studies → Original source
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2021-02-17
Rheumatoid arthritis: Extra-articular manifestations and comorbidities
52/100 ✓ Peer-reviewed How common it is Autoimmunity reviews
Key finding: Compared to the general population, patients with RA have twice the risk of myocardial infarction and up to 50% increased CV mortality risk. +2 more findings
Full summary, score breakdown and related studies → Original source
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2021-02-16
Associations among Cognitive Functions, Plasma DNA, and Diffusion Tensor Image along the Perivascular Space (DTI-ALPS) in Patients with Parkinson's Disease
49/100 ✓ Peer-reviewed Inflammation and the immune system Oxidative medicine and cellular longevity
Key finding: Parkinson's disease (PD) is a common neurodegenerative disease associated with accumulation of misfolding proteins and increased neuroinflammation, which may further impair the glymphatic system. +3 more findings
Full summary, score breakdown and related studies → Original source
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2021-02-16
Cognitive Profile and Markers of Alzheimer Disease-Type Pathology in Patients With Lewy Body Dementias
48/100 ✓ Peer-reviewed Tau biomarkers Neurology
Key finding: We selected 57 patients with LBD (dementia with Lewy bodies [DLB], n = 38; Parkinson disease dementia [PDD], n = 19) with available AD CSF biomarkers and neuropsychological data. +3 more findings
Full summary, score breakdown and related studies → Original source
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2021-02-16
Machine Learning Algorithms and Statistical Approaches for Alzheimer's Disease Analysis Based on Resting-State EEG Recordings: A Systematic Review
55/100 ✓ Peer-reviewed Digital health tools International journal of neural systems
Key finding: Alzheimer's Disease (AD) is a neurodegenerative disorder and the most common type of dementia with a great prevalence in western countries.
Full summary, score breakdown and related studies → Original source
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2021-02-15
Machine learning identifies candidates for drug repurposing in Alzheimer's disease
47/100 ✓ Peer-reviewed Drug development Nature communications
Key finding: Clinical trials of novel therapeutics for Alzheimer's Disease (AD) have consumed a large amount of time and resources with largely negative results.
Full summary, score breakdown and related studies → Original source
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2021-02-15
Genome-wide meta-analysis, fine-mapping and integrative prioritization implicate new Alzheimer's disease risk genes
74/100 ✓ Peer-reviewed Genetics Nature genetics
Key finding: Genome-wide association studies have discovered numerous genomic loci associated with Alzheimer's disease (AD); yet the causal genes and variants are incompletely identified. +1 more finding
Full summary, score breakdown and related studies → Original source
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2021-02-15
Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture
64/100 ✓ Peer-reviewed Lewy body dementia Nature genetics
Key finding: The genetic basis of Lewy body dementia (LBD) is not well understood. +3 more findings
Full summary, score breakdown and related studies → Original source
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2021-02-15
Plasma d-glutamate levels for detecting mild cognitive impairment and Alzheimer's disease: Machine learning approaches
47/100 ✓ Peer-reviewed Digital health tools Journal of psychopharmacology (Oxford, England)
Key finding: This study aimed to use peripheral plasma d-glutamate levels to differentiate patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) from healthy individuals and to evaluate its prediction ability using machine learning. +3 more findings
Full summary, score breakdown and related studies → Original source
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2021-02-15
Association of Digital Clock Drawing With PET Amyloid and Tau Pathology in Normal Older Adults
56/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: DCTclock discriminates between diagnostic groups and improves upon traditional cognitive tests for detecting biomarkers of amyloid and tau pathology in CN older adults. +2 more findings
Full summary, score breakdown and related studies → Original source
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2021-02-15
Home-based multimodal exercise program in older people with Alzheimer disease: Randomized controlled trial protocol
37/100 ✓ Peer-reviewed Treatments Physiotherapy research international : the journal for researchers and clinicians in physical therapy
Key finding: Improvements in the aspects evaluated are expected in the IG compared to CG.
Full summary, score breakdown and related studies → Original source
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2021-02-14
Association between exenatide use and incidence of Alzheimer's disease
77/100 ✓ Peer-reviewed Drug development Alzheimer's & dementia (New York, N. Y.)
Key finding: The sample was mostly female (65%), White (76%), and 74 years old on average. +4 more findings
Full summary, score breakdown and related studies → Original source
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2021-02-14
HbA1c and brain health across the entire glycaemic spectrum
57/100 ✓ Peer-reviewed Long-term cohort studies Diabetes, obesity & metabolism
Key finding: HbA1c and diabetes diagnosis were used to define baseline glycaemic categories. +3 more findings
Full summary, score breakdown and related studies → Original source
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2021-02-14
Plasma p-tau231: a new biomarker for incipient Alzheimer's disease pathology
74/100 ✓ Peer-reviewed Getting a diagnosis Acta neuropathologica
Key finding: Furthermore, plasma p-tau231 was significantly increased in amyloid-β PET quartiles 2-4, whereas CSF p-tau217 and plasma p-tau181 increased only at quartiles 3-4 and 4, respectively. +1 more finding
Full summary, score breakdown and related studies → Original source
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2021-02-13
Genetic study of young-onset dementia using targeted gene panel sequencing in Taiwan
55/100 ✓ Peer-reviewed Risk genes beyond APOE American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
Key finding: Plasma level of total tau was increased and Aβ42 and Aβ40 levels decreased in all groups of dementia patients compared to controls. +1 more finding
Full summary, score breakdown and related studies → Original source
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2021-02-13
Plasma p-tau181, p-tau217, and other blood-based Alzheimer's disease biomarkers in a multi-ethnic, community study
61/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Blood-based AD biomarker concentrations are associated with pathological and clinical diagnoses and can predict future development of clinical AD, providing evidence that they can be incorporated into multi-ethnic, community-based studies. +2 more findings
Full summary, score breakdown and related studies → Original source
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2021-02-12
High levels of 27-hydroxycholesterol results in synaptic plasticity alterations in the hippocampus
41/100 ✓ Peer-reviewed Disease mechanisms Scientific reports
Key finding: Alterations in brain cholesterol homeostasis in midlife are correlated with a higher risk of developing Alzheimer's disease (AD). +4 more findings
Full summary, score breakdown and related studies → Original source
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2021-02-12
Sleep in the Aging Brain
41/100 ✓ Peer-reviewed Risk factors Brain sciences
Key finding: However, maturational changes in sleep associated with aging do not easily appear as main factors, even though sleep alterations in the aging process lead to many detrimental consequences.
Full summary, score breakdown and related studies → Original source
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2021-02-12
18F-AV-1451 positron emission tomography in neuropathological substrates of corticobasal syndrome
52/100 ✓ Peer-reviewed Brain scans and imaging Brain : a journal of neurology
Key finding: Subjects without amyloid, including three with pathologically confirmed corticobasal degeneration, showed greater regional 18F-AV-1451 retention and associated regional atrophy in areas commonly associated with corticobasal degeneration pathology than healthy control subjects [retention was higher compared to healthy controls (P = 0.0011), driven especially by the precentral gyrus (P = 0.011) and pallidum (P < 0.0001), and greater atrophy was seen in subjects compared to control subjects (P = 0.0004)]. +2 more findings
Full summary, score breakdown and related studies → Original source
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2021-02-12
Mitovesicles are a novel population of extracellular vesicles of mitochondrial origin altered in Down syndrome
43/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Science advances
Key finding: Mitochondrial dysfunction is an established hallmark of aging and neurodegenerative disorders such as Down syndrome (DS) and Alzheimer's disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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