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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 9,276–9,300 of 27,380 studies, newest first · page 372 of 1096.

January 2022 25

  1. 2022-01-28

    Brain-derived neurotrophic factor in Alzheimer's disease and its pharmaceutical potential

    ✓ Peer-reviewed Disease mechanisms Translational neurodegeneration

    Key finding: A growing body of evidence suggests that pathological alterations to neuronal circuits and synapses may provide a mechanistic link between amyloid β (Aβ) and tau pathology and thus may serve as an obligatory relay of the cognitive impairment in AD.

    Full summary, score breakdown and related studies → Original source

  2. 2022-01-27

    Medicare Beneficiary Factors Associated with Skilled Nursing Facility Lengths of Stay

    ✓ Peer-reviewed Costs and economics Journal of applied gerontology : the official journal of the Southern Gerontological Society

    Key finding: The objectives of this study are (1) to identify beneficiary-level characteristics associated with skilled nursing facility (SNF) length of stay (LOS), and (2) to determine if significant differences in LOS exist for vulnerable populations at the individual level or among nursing homes that serve a disproportionate share of vulnerable populations. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2022-01-27

    Protein degradation-associated mechanisms that are affected in Alzheimer´s disease

    ✓ Peer-reviewed Disease mechanisms Molecular and cellular biochemistry

    Key finding: Alzheimer's disease (AD) is the most common type of dementia associated with age-related neurodegeneration. +1 more finding

    Full summary, score breakdown and related studies → Original source

  4. 2022-01-27

    Deciphering the Roles of Metformin in Alzheimer's Disease: A Snapshot

    ✓ Peer-reviewed Drug development Frontiers in pharmacology

    Key finding: Evidence from clinical studies has demonstrated that metformin use contributes to a lower risk of developing AD and better cognitive performance, which might be modified by interactors such as diabetic status and APOE-ε4 status.

    Full summary, score breakdown and related studies → Original source

  5. 2022-01-27

    Assessing Reactive Astrogliosis with 18F-SMBT-1 Across the Alzheimer Disease Spectrum

    ✓ Peer-reviewed Brain scans and imaging Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    Key finding: 18 F-SMBT-1 yielded high-contrast images at steady state (60-80 min after injection). +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2022-01-27

    First-in-Humans Evaluation of 18F-SMBT-1, a Novel 18F-Labeled Monoamine Oxidase-B PET Tracer for Imaging Reactive Astrogliosis

    ✓ Peer-reviewed Brain scans and imaging Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    Key finding: 18 F-SMBT-1 showed robust entry into the brain and reversible binding kinetics, with high tracer retention in basal ganglia, intermediate retention in cortical regions, and the lowest retention in cerebellum and white matter, which tightly follows the known regional brain distribution of MAO-B ( R 2 = 0.84). +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2022-01-26

    Cardiometabolic and Vascular Disease Factors and Mild Cognitive Impairment and Dementia

    ✓ Peer-reviewed Risk factors Gerontology

    Key finding: Prevalent MCI and dementia, compared with normal cognition, was associated with higher proportions of persons with any CMVD, hypertension, diabetes, coronary heart disease, atrial fibrillation, or stroke. +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2022-01-26

    A hybrid approach unveils drug repurposing candidates targeting an Alzheimer pathophysiology mechanism

    ✓ Peer-reviewed Drug development Patterns (New York, N.Y.)

    Key finding: The high number of failed pre-clinical and clinical studies for compounds targeting Alzheimer disease (AD) has demonstrated that there is a need to reassess existing strategies.

    Full summary, score breakdown and related studies → Original source

  9. 2022-01-26

    Functional insight into LOAD-associated microglial response genes

    ✓ Peer-reviewed Genetics Open biology

    Key finding: The majority of AD research has been dedicated to the understanding of two major AD hallmarks (i.e. +4 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2022-01-26

    Rehmannioside A improves cognitive impairment and alleviates ferroptosis via activating PI3K/AKT/Nrf2 and SLC7A11/GPX4 signaling pathway after ischemia

    ✓ Peer-reviewed Vascular contributions Journal of ethnopharmacology

    Key finding: Materials and methods Differentially expressed proteins (DEPs) in patients after cerebral ischemic stroke were revealed by a RayBio protein array. +3 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2022-01-25

    Magnetic Resonance Imaging in Tauopathy Animal Models

    ✓ Peer-reviewed Brain scans and imaging Frontiers in aging neuroscience

    Key finding: High-field MRI has been applied for in vivo imaging in animal models of tauopathy, including diffusion tensor imaging for white matter integrity, arterial spin labeling for cerebral blood flow, resting-state functional MRI for functional connectivity, volumetric MRI for neurodegeneration, and MR spectroscopy. +4 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2022-01-25

    Differential levels of plasma biomarkers of neurodegeneration in Lewy body dementia, Alzheimer's disease, frontotemporal dementia and progressive supranuclear palsy

    ✓ Peer-reviewed Biomarkers Journal of neurology, neurosurgery, and psychiatry

    Key finding: This large study shows the role of plasma biomarkers in differentiating patients with different dementias, and at monitoring longitudinal change. +4 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2022-01-25

    Peripheral immunity is associated with the risk of incident dementia

    ✓ Peer-reviewed Long-term cohort studies Molecular psychiatry

    Key finding: However, few studies focused on peripheral immunity and dementia. +3 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2022-01-24

    Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are shaping how we study and target Tauopathies

    ✓ Peer-reviewed Drug development Chemical Society reviews

    Key finding: Despite significant advances in understanding the morphological and structural properties of Tau fibrils, many fundamental questions remain about what causes Tau to aggregate in the first place.

    Full summary, score breakdown and related studies → Original source

  15. 2022-01-24

    Risk Factors for Phenoconversion in Rapid Eye Movement Sleep Behavior Disorder

    ✓ Peer-reviewed Disparities Annals of neurology

    Key finding: Our findings elucidate the predictive values of environmental factors and comorbid conditions in identifying RBD patients at higher risk of phenoconversion. +3 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2022-01-24

    Antisense oligonucleotide silencing of FUS expression as a therapeutic approach in amyotrophic lateral sclerosis

    ✓ Peer-reviewed Caregiving Nature medicine

    Key finding: Fused in sarcoma (FUS) is an RNA-binding protein that is genetically and pathologically associated with rare and aggressive forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). +1 more finding

    Full summary, score breakdown and related studies → Original source

  17. 2022-01-24

    Plasma protein biomarker model for screening Alzheimer disease using multiple reaction monitoring-mass spectrometry

    ✓ Peer-reviewed Biomarkers Scientific reports

    Key finding: The models were more accurate in diagnosing AD, compared with single APOE genotypes and the K-MMSE score.

    Full summary, score breakdown and related studies → Original source

  18. 2022-01-23

    Inflammasome Signaling in the Aging Brain and Age-Related Neurodegenerative Diseases

    ✓ Peer-reviewed Inflammation and the immune system Molecular neurobiology

    Key finding: Although recent studies have revealed the inflammasomes' functionality in both in vitro and in vivo models, many inflammasome signaling cascade activations during biological aging, neuroinflammation, and neurodegeneration are still ambiguous.

    Full summary, score breakdown and related studies → Original source

  19. 2022-01-23

    NIH Primary and Secondary Prevention Research in Humans: a Portfolio Analysis of Study Designs Used in 2012-2019

    ✓ Peer-reviewed Risk factors Prevention science : the official journal of the Society for Prevention Research

    Key finding: This manuscript examines the research questions being addressed in prevention research by characterizing the distribution and trends of study designs included in primary and secondary prevention research supported by the National Institutes of Health through grants and cooperative agreements, together with the types of prevention research, populations, rationales, exposures, and outcomes associated with each type of design. +3 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2022-01-21

    PROTACs technology for treatment of Alzheimer's disease: Advances and perspectives

    ✓ Peer-reviewed Disease mechanisms Acta materia medica

    Key finding: Many neurodegenerative diseases are because of proteinopathies that results from unusual protein accumulations and aggregations. +1 more finding

    Full summary, score breakdown and related studies → Original source

  21. 2022-01-21

    Cognitive functions in late-life depression

    ✓ Peer-reviewed Risk factors Geriatrie et psychologie neuropsychiatrie du vieillissement

    Key finding: Many cognitive functions may be concerned and can be explained by frontostriatal brain circuits and hippocampus dysfunctions partly through abnormalities related to cerebrovascular diseases. +4 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2022-01-21

    Metals, Nanoparticles, Particulate Matter, and Cognitive Decline

    ✓ Peer-reviewed Prevention trials Frontiers in neurology

    Key finding: PM2.5 exposure is associated with impaired cognitive performance, neurobehavioral alterations, incidence of dementia, and Alzheimer's disease (AD) risk.

    Full summary, score breakdown and related studies → Original source

  23. 2022-01-21

    Automated analysis of facial emotions in subjects with cognitive impairment

    ✓ Peer-reviewed Cognitive tests and assessment PloS one

    Key finding: Compared to cognitively unimpaired (CU) participants, CI participants expressed significantly less positive emotions, more negative emotions, and higher facial expressiveness during the test. +2 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2022-01-21

    A Perspective on Nrf2 Signaling Pathway for Neuroinflammation: A Potential Therapeutic Target in Alzheimer's and Parkinson's Diseases

    ✓ Peer-reviewed Inflammation and the immune system Frontiers in cellular neuroscience

    Key finding: These neurological disorders are characterized by the accumulation of misfolded proteins such as amyloid-ß (Aß), tau protein and α-synuclein, contributing to mitochondrial fragmentation, oxidative stress, and neuroinflammation. +3 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2022-01-20

    Lifespan evolution of neurocognitive impairment in schizophrenia - A narrative review

    ✓ Peer-reviewed Prevention trials Schizophrenia research. Cognition

    Key finding: Overall, studies suggest that mild cognitive impairment in individuals who develop schizophrenia or related disorders is already present during early childhood.

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →