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Optical coherence tomography and angiography in Alzheimer's disease and other cognitive disorders
Mohamed Moussa, Yousra Falfoul, Amina Nasri, Khaled El Matri, Imen Kacem, Saloua Mrabet, Ahmed Chebil, Alya Gharbi et al.. European journal of ophthalmology, 2023-01-09
Topic: Plasma and spinal-fluid biomarkers
Ninety-one eyes of AD patients and 53 eyes of patients with other dementias were included. Retinal deposits were found in 6.59% of AD cases. OCT highlighted the presence of hyperreflective deposits and localized areas of outer retina and ellipsoid zone disruption, respectively in 20.87% and 15.38% of AD cases. Hyperreflective foci were noted within inner retinal layers in 4.39% of AD cases. Quantitative analysis revealed a thicker nasal retinal nerve fiber layer (p = 0.001) and ganglion cell complex in superior (p = 0.011) and temporal quadrants (p = 0.009) in eyes of AD patients, compared to other dementias. OCT-A showed a significantly higher fractal dimension of both superficial and deep capillary plexus (p = 0.005), with lower choriocapillaris density (p = 0.003) in AD patients. Structural OCT could highlight the presence of hyperreflective deposits in AD, probably reflecting beta-amyloid deposits, associated to outer retinal disruptions. Quantitative OCT analysis showed structural differences between AD patients and other dementias, and combined OCT-A could identify microvascular changes in AD patients representing new potential differential diagnosis criteria.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Moussa, M., Falfoul, Y., Nasri, A., El Matri, K., Kacem, I., Mrabet, S., et al. (2023). Optical coherence tomography and angiography in Alzheimer's disease and other cognitive disorders. European journal of ophthalmology. https://doi.org/10.1177/11206721221148952
Vancouver
Moussa M, Falfoul Y, Nasri A, El Matri K, Kacem I, Mrabet S, et al. Optical coherence tomography and angiography in Alzheimer's disease and other cognitive disorders. European journal of ophthalmology. 2023. doi:10.1177/11206721221148952. PMID: 36617984.
BibTeX
@article{moussa2023-36617984,
author = {Moussa, Mohamed and Falfoul, Yousra and Nasri, Amina and El Matri, Khaled and Kacem, Imen and Mrabet, Saloua and Chebil, Ahmed and Gharbi, Alya and others},
title = {{Optical coherence tomography and angiography in Alzheimer's disease and other cognitive disorders}},
journal = {European journal of ophthalmology},
year = {2023},
doi = {10.1177/11206721221148952},
pmid = {36617984},
url = {https://doi.org/10.1177/11206721221148952}
}
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Key findings
- Ninety-one eyes of AD patients and 53 eyes of patients with other dementias were included.
- Retinal deposits were found in 6.59% of AD cases.
- OCT highlighted the presence of hyperreflective deposits and localized areas of outer retina and ellipsoid zone disruption, respectively in 20.87% and 15.38% of AD cases.
- Hyperreflective foci were noted within inner retinal layers in 4.39% of AD cases.
- Quantitative analysis revealed a thicker nasal retinal nerve fiber layer (p = 0.001) and ganglion cell complex in superior (p = 0.011) and temporal quadrants (p = 0.009) in eyes of AD patients, compared to other dementias.
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Study details
- Study designcross-sectional
- Effect size6.59%; 20.87%; 15.38%
- Evidence strengthLow
How this study scored 52/100
Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for sample size, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 29 of the 56 points we could judge it on, which is 52 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (European journal of ophthalmology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 36617984) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 29 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 29 of the 56 points we could judge it on is 52 out of 100. |
| Total | 52 / 100 | — |
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