Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 20,526–20,550 of 27,380 studies, newest first · page 822 of 1096.
October 2010 19
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2010-10-01
Drug utilization in Belgian nursing homes: impact of residents' and institutional characteristics
53/100 ✓ Peer-reviewed End-of-life care Pharmacoepidemiology and drug safety
Key finding: A high level of drug utilization, influenced by the characteristics of residents and the institution, was observed in Belgian nursing homes. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-10-01
Amyloid-beta oligomers impair fear conditioned memory in a calcineurin-dependent fashion in mice
36/100 ✓ Peer-reviewed Disease mechanisms Journal of neuroscience research
Key finding: Recent evidence indicates that A beta oligomers are recruited at the synapse, oppose expression of long-term potentiation (LTP), perturb intracellular calcium balance, disrupt dendritic spines, and induce memory deficits. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-10-01
Amyloid efflux transporter expression at the blood-brain barrier declines in normal aging
36/100 ✓ Peer-reviewed Disease mechanisms Journal of neuropathology and experimental neurology
Key finding: These data indicate that alterations in LRP-1 and P-gp expression seem to contribute progressively to Aβ accumulation in aging.
Full summary, score breakdown and related studies → Original source
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2010-10-01
Saffron in the treatment of patients with mild to moderate Alzheimer's disease: a 16-week, randomized and placebo-controlled trial
60/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of clinical pharmacy and therapeutics
Key finding: Crocus sativus (saffron) may inhibit the aggregation and deposition of amyloid β in the human brain and may therefore be useful in Alzheimer's disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-10-01
Nasu-Hakola disease: The first case reported by Nasu and review: The 50th Anniversary of Japanese Society of Neuropathology
40/100 ✓ Peer-reviewed TREM2 and immune genetics Neuropathology : official journal of the Japanese Society of Neuropathology
Key finding: It is an autosomal recessive inherited disorder characterized by progressive dementia and repeated pathological fractures during adolescence. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-10-01
The arsenic exposure hypothesis for Alzheimer disease
38/100 ✓ Peer-reviewed Risk genes beyond APOE Alzheimer disease and associated disorders
Key finding: On the basis of this literature, we propose the Arsenic Exposure Hypothesis for AD that is inclusive of and cooperative with the existing hypotheses. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-10-01
Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease
48/100 ✓ Peer-reviewed Mild cognitive impairment Brain : a journal of neurology
Key finding: Gene ontology over-representation and functional gene network analyses indicate an increase in synaptic activity and changes in plasticity during the very early pre-symptomatic stage of the disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-10-01
TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia
57/100 ✓ Peer-reviewed Lewy body dementia The Lancet. Neurology
Key finding: Abnormal intracellular protein aggregates comprise a key characteristic in most neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-10-01
An analysis of communication in conversation in patients with dementia
41/100 ✓ Peer-reviewed Digital health tools Neuropsychologia
Key finding: Patients were compared with 47 matching control subjects. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-10-01
Validity and reliability of the Zarit Burden Interview in assessing caregiving burden
46/100 ✓ Peer-reviewed Caregiving Annals of the Academy of Medicine, Singapore
Key finding: The results in this study demonstrated that the Zarit Burden Interview is a valid and reliable instrument for measuring the burden of caregivers of PWD in Singapore. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-10-01
Caregiver burden in Alzheimer disease: cross-sectional and longitudinal patient correlates
47/100 ✓ Peer-reviewed Caregiving The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: Severity of psychiatric symptoms, behavioral disturbances, and patients' quality of life are the main correlates of caregivers' experience burden. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-10-01
Premorbid cognitive leisure independently contributes to cognitive reserve in multiple sclerosis
47/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: Also, patients with MS who engaged in more cognitive leisure were able to withstand more severe brain atrophy at a given cognitive status.
Full summary, score breakdown and related studies → Original source
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2010-10-01
Hippocampal CA1 apical neuropil atrophy in mild Alzheimer disease visualized with 7-T MRI
58/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: CA1 apical neuropil atrophy is apparent in patients with mild AD. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-10-01
EFNS guidelines for the diagnosis and management of Alzheimer's disease
65/100 ✓ Peer-reviewed Getting a diagnosis European journal of neurology
Key finding: A number of new recommendations and good practice points are made, namely in CSF, neuropsychology, neuroimaging and reviewing non-evidence based therapies. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-10-01
What predicts mortality in Parkinson disease?: a prospective population-based long-term study
58/100 ✓ Peer-reviewed Prevention and risk Neurology
Key finding: Of 230 patients, 211 (92%) died during the study period. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-10-01
Treating neuropsychiatric symptoms in dementia with Lewy bodies: a randomized controlled-trial
60/100 ✓ Peer-reviewed Treatments Alzheimer disease and associated disorders
Key finding: A significantly higher proportion of participants with DLB (68%) than with AD (50%) discontinued the study prematurely. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-10-01
Goal-oriented cognitive rehabilitation for people with early-stage Alzheimer disease: a single-blind randomized controlled trial of clinical efficacy
66/100 ✓ Peer-reviewed Treatments The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: The findings support the clinical efficacy of CR in early-stage AD.
Full summary, score breakdown and related studies → Original source
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2010-10-01
Homocysteine and holotranscobalamin and the risk of Alzheimer disease: a longitudinal study
41/100 ✓ Peer-reviewed Genetics Neurology
Key finding: This study suggests that both tHcy and holoTC may be involved in the development of AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-10-01
The genetics of Alzheimer disease: back to the future
57/100 ✓ Peer-reviewed Genetics Neuron
Key finding: As a result, a large proportion of the heritability of AD continues to remain unexplained by the currently known disease genes.
Full summary, score breakdown and related studies → Original source
September 2010 6
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2010-09-30
Hearing loss is negatively related to episodic and semantic long-term memory but not to short-term memory
52/100 ✓ Peer-reviewed Risk factors Journal of speech, language, and hearing research : JSLHR
Key finding: The overall relationships between hearing loss and memory systems were predicted by the ease of language understanding model (J. Rönnberg, 2003), but the exact mechanisms of episodic memory decline in hearing aid users (i.e., mismatch/disuse, attentional resources, or information degradation) remain open for further experiments. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-09-28
Does apolipoprotein E genotype modify the clinical expression of ALS?
38/100 ✓ Peer-reviewed Genetics European journal of neurology
Key finding: The frequencies of individual ApoE genotypes did not differ between patients with ALS and ALS-free Caucasian populations. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-09-28
Behavioural symptoms in patients with Alzheimer's disease and their association with cognitive impairment
51/100 ✓ Peer-reviewed Cognitive tests and assessment BMC neurology
Key finding: Behavioural and psychological symptoms of dementia (BPSD) are non-cognitive symptoms commonly associated to Alzheimer's disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-09-28
Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion
43/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: Cellular and in vivo studies suggested that statins might decrease the generation of the amyloid β-peptide (Aβ) from the β-amyloid precursor protein. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-09-27
Alzheimer's CSF markers in older schizophrenia patients
40/100 ✓ Peer-reviewed Tau biomarkers International journal of geriatric psychiatry
Key finding: Cognitive impairment is prevalent in older schizophrenia patients but its biological basis is unknown. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-09-24
SB-742457 and donepezil in Alzheimer disease: a randomized, placebo-controlled study
58/100 ✓ Peer-reviewed Treatments International journal of geriatric psychiatry
Key finding: In this exploratory study, SB-742457 and donepezil were associated with improvements in global function. +1 more finding
Full summary, score breakdown and related studies → Original source
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