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TREM2hi resident macrophages protect the septic heart by maintaining cardiomyocyte homeostasis
Zhang K, Wang Y, Chen S, Mao J, Jin Y, Ye H, Zhang Y, Liu X et al.. Nature metabolism, 2023-01-12
Topic: Brain proteins, microglia and lab models
Plain-language summary
Sepsis-induced cardiomyopathy (SICM) is common in septic patients with a high mortality and is characterized by an abnormal immune response. Owing to cellular heterogeneity, understanding the roles of immune cell subsets in SICM has been challenging. Here we identify a unique subpopulation of cardiac-resident macrophages termed CD163 + RETNLA + (Mac1), which undergoes self-renewal during sepsis and can be targeted to prevent SICM.
What this study adds
Evidence grade: Low
This study is about sepsis-induced cardiomyopathy and identifies a cardiac-resident macrophage subpopulation in a mouse model of sepsis, not Alzheimer's disease, so it provides no direct information about treating, curing or preventing Alzheimer's. Its findings come from single-cell RNA sequencing and fate mapping in mice.
Taken from this record’s own fields, not from reading the paper. The grade is assigned from the abstract’s wording; what that means.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Zhang, K., Wang, Y., Chen, S., Mao, J., Jin, Y., Ye, H., et al. (2023). TREM2hi resident macrophages protect the septic heart by maintaining cardiomyocyte homeostasis. Nature metabolism. https://doi.org/10.1038/s42255-022-00715-5
Vancouver
Zhang K, Wang Y, Chen S, Mao J, Jin Y, Ye H, et al. TREM2hi resident macrophages protect the septic heart by maintaining cardiomyocyte homeostasis. Nature metabolism. 2023. doi:10.1038/s42255-022-00715-5. PMID: 36635449.
BibTeX
@article{zhang2023-36635449,
author = {Zhang, K. and Wang, Y. and Chen, S. and Mao, J. and Jin, Y. and Ye, H. and Zhang, Y. and Liu, X. and others},
title = {{TREM2hi resident macrophages protect the septic heart by maintaining cardiomyocyte homeostasis}},
journal = {Nature metabolism},
year = {2023},
doi = {10.1038/s42255-022-00715-5},
pmid = {36635449},
url = {https://doi.org/10.1038/s42255-022-00715-5}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Owing to cellular heterogeneity, understanding the roles of immune cell subsets in SICM has been challenging.
- Here we identify a unique subpopulation of cardiac-resident macrophages termed CD163 + RETNLA + (Mac1), which undergoes self-renewal during sepsis and can be targeted to prevent SICM.
- By combining single-cell RNA sequencing with fate mapping in a mouse model of sepsis, we demonstrate that the Mac1 subpopulation has distinct transcriptomic signatures enriched in endocytosis and displays high expression of TREM2 (TREM2 hi ).
- TREM2 hi Mac1 cells actively scavenge cardiomyocyte-ejected dysfunctional mitochondria.
Why it matters
This study is about sepsis-induced cardiomyopathy and identifies a cardiac-resident macrophage subpopulation in a mouse model of sepsis, not Alzheimer's disease, so it provides no direct information about treating, curing or preventing Alzheimer's. Its findings come from single-cell RNA sequencing and fate mapping in mice.
New to this subject? Start with our plain-English guide: Genetics →
Study details
- Evidence strengthLow
How this study scored 48/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Nature metabolism) |
| Journal's citation record | 1 / 4 | Nature Metabolism: journal h-index 148 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 214 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 42.8 citations a year over 5 year(s) since 2023 |
| Impact for its field and year | 5 / 6 | Cited 37.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 3 / 4 | Cited 196 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Xiangming Fang: h-index 49 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Zhejiang University: institution h-index 1,040 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 36635449) |
| Free to read | 2 / 2 | Free to read |
| Total | 48 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1038/s42255-022-00715-5
- PubMed: 36635449
- Original source →
- Free full text: Nature Metabolism →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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