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57/100

✓ Peer-reviewed alzhub usefulness score 57 out of 100. TREM2 and immune genetics

Topic: Brain proteins, microglia and lab models

Microglial activation occurs early in Alzheimer's disease (AD) and previous studies reported both detrimental and protective effects of microglia on AD progression. Here, we used CSF sTREM2 to investigate disease stage-dependent drivers of microglial activation and to determine downstream consequences on AD progression. We included 402 patients with measures of earliest beta-amyloid (CSF Aβ 1-42 ) and late-stage fibrillary Aβ pathology (amyloid-PET centiloid), as well as sTREM2, p-tau 181 , and FDG-PET.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Biel, D., Suárez-Calvet, M., Hager, P., Rubinski, A., Dewenter, A., Steward, A., et al. (2023). sTREM2 is associated with amyloid-related p-tau increases and glucose hypermetabolism in Alzheimer's disease. EMBO molecular medicine. https://doi.org/10.15252/emmm.202216987

Vancouver

Biel D, Suárez-Calvet M, Hager P, Rubinski A, Dewenter A, Steward A, et al. sTREM2 is associated with amyloid-related p-tau increases and glucose hypermetabolism in Alzheimer's disease. EMBO molecular medicine. 2023. doi:10.15252/emmm.202216987. PMID: 36620941.

BibTeX

@article{biel2023-36620941,
  author  = {Biel, D. and Suárez-Calvet, M. and Hager, P. and Rubinski, A. and Dewenter, A. and Steward, A. and Roemer, S. and Ewers, M. and others},
  title   = {{sTREM2 is associated with amyloid-related p-tau increases and glucose hypermetabolism in Alzheimer's disease}},
  journal = {EMBO molecular medicine},
  year    = {2023},
  doi     = {10.15252/emmm.202216987},
  pmid    = {36620941},
  url     = {https://doi.org/10.15252/emmm.202216987}
}

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Key findings

Here, we used CSF sTREM2 to investigate disease stage-dependent drivers of microglial activation and to determine downstream consequences on AD progression.
We included 402 patients with measures of earliest beta-amyloid (CSF Aβ 1-42 ) and late-stage fibrillary Aβ pathology (amyloid-PET centiloid), as well as sTREM2, p-tau 181 , and FDG-PET.
To determine disease stage, we stratified participants into early Aβ-accumulators (Aβ CSF+/PET-; n = 70) or late Aβ-accumulators (Aβ CSF+/PET+; n = 201) plus 131 controls.
In early Aβ-accumulators, higher centiloid was associated with cross-sectional/longitudinal sTREM2 and p-tau 181 increases.

Why it matters

In 402 patients, cerebrospinal fluid sTREM2 was associated with amyloid-related p-tau increases and glucose hypermetabolism, and the authors note that microglia have been reported to have both detrimental and protective effects on Alzheimer's disease progression. This is a cross-sectional study, so it cannot show whether microglial activation causes or protects against disease progression.

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Study details

Study designcross-sectional
Participants70
Evidence strengthModerate

How this study scored 57/100

Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 55 of the 96 points we could judge it on, which is 57 out of 100.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (EMBO molecular medicine)
Journal's citation record	2 / 4	EMBO Molecular Medicine: journal h-index 186 (OpenAlex, 2026-10-29)
Study design	4 / 12	A snapshot of people at one point in time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	3 / 5	2023 — within 6 year(s) of the newest study here
Sample size	1 / 4	70 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	4 / 7	Cited 54 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	10.8 citations a year over 5 year(s) since 2023
Impact for its field and year	3 / 6	Cited 4.5× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 5 other studies in this library
Still being cited	2 / 4	Cited 46 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	— / 4	Senior author's record not available — left out of this score
Institution's track record	1 / 3	Ludwig-Maximilians-Universität München: institution h-index 1,224 (OpenAlex)
Multi-centre collaboration	3 / 3	OpenAlex lists 13 institution(s) in 3 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 36620941)
Free to read	2 / 2	Free to read
Points	55 / 96	Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 55 of the 96 points we could judge it on is 57 out of 100.
Total	57 / 100	—

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