Apolipoprotein E Polymorphisms in Andean Population of Jujuy, Argentina
Arturo Nicolás Trigo, Marina Muzzio, Marcelo Isidro Figueroa, Emma Laura Alfaro-Gómez, Graciela Bailliet, Hernán Javier Dopazo, José Edgardo Dipierri. Journal of Alzheimer's disease reports, 2024-01-18
Topic: Genetics and APOE
Plain-language summary
The pleiotropic nature of the apolipoprotein E (APOE) gene is associated with complex diseases in different populations. We analyzed APOE polymorphisms in 76 individuals from Jujuy - Argentina using NGS technology. The observed genotypes align with the expected Hardy-Weinberg equilibrium. APOE3 was the most common allele, followed by APOE4 and APOE2. The allele distribution pattern is consistent with findings in previously studied populations of Native Americans and Asians. The E4 allele's low frequency, always observed in a heterozygous state, raises questions regarding its relevance in explaining dementia and longevity associated with this marker in the Central Andes.
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APA 7th
Trigo, A. N., Muzzio, M., Figueroa, M. I., Alfaro-Gómez, E. L., Bailliet, G., Dopazo, H. J., et al. (2024). Apolipoprotein E Polymorphisms in Andean Population of Jujuy, Argentina. Journal of Alzheimer's disease reports. https://doi.org/10.3233/adr-230061
Vancouver
Trigo AN, Muzzio M, Figueroa MI, Alfaro-Gómez EL, Bailliet G, Dopazo HJ, et al. Apolipoprotein E Polymorphisms in Andean Population of Jujuy, Argentina. Journal of Alzheimer's disease reports. 2024. doi:10.3233/adr-230061. PMID: 38312530.
BibTeX
@article{trigo2024-38312530,
author = {Trigo, Arturo Nicolás and Muzzio, Marina and Figueroa, Marcelo Isidro and Alfaro-Gómez, Emma Laura and Bailliet, Graciela and Dopazo, Hernán Javier and Dipierri, José Edgardo},
title = {{Apolipoprotein E Polymorphisms in Andean Population of Jujuy, Argentina}},
journal = {Journal of Alzheimer's disease reports},
year = {2024},
doi = {10.3233/adr-230061},
pmid = {38312530},
url = {https://doi.org/10.3233/adr-230061}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- The pleiotropic nature of the apolipoprotein E (APOE) gene is associated with complex diseases in different populations.
- The E4 allele's low frequency, always observed in a heterozygous state, raises questions regarding its relevance in explaining dementia and longevity associated with this marker in the Central Andes.
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Study details
- Participants76
- Evidence strengthLow
How this study scored 50/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 28 of the 56 points we could judge it on, which is 50 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Alzheimer's disease reports) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 1 / 4 | 76 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 38312530) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 28 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 28 of the 56 points we could judge it on is 50 out of 100. |
| Total | 50 / 100 | — |
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