Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 9,401–9,425 of 27,380 studies, newest first · page 377 of 1096.
January 2022 25
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2022 year only
Alzheimer's Disease Variant Portal: A Catalog of Genetic Findings for Alzheimer's Disease
41/100 ✓ Peer-reviewed Genetics Journal of Alzheimer's disease : JAD
Key finding: ADVP V1.0 (February 2021) catalogs 6,990 associations related to disease-risk, expression quantitative traits, endophenotypes, or neuropathology. +4 more findings
Full summary, score breakdown and related studies → Original source
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2022 year only
Effects of ApoE4 and ApoE2 genotypes on subcortical magnetic susceptibility and microstructure in 27,535 participants from the UK Biobank
54/100 ✓ Peer-reviewed Genetics Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
Key finding: Disrupted iron homeostasis is associated with several neurodegenerative diseases, including Alzheimer's disease (AD), and may be partially modulated by genetic risk factors. +3 more findings
Full summary, score breakdown and related studies → Original source
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2022 year only
Isoform-Dependent Effects of Apolipoprotein E on Sphingolipid Metabolism in Neural Cells
41/100 ✓ Peer-reviewed Genetics Journal of Alzheimer's disease : JAD
Key finding: In the brains of Apoeshl mice, the levels of apoM were lower, while those of ceramides were higher. +4 more findings
Full summary, score breakdown and related studies → Original source
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2022 year only
Validity of the Web-Based, Self-Directed, NeuroCognitive Performance Test in Mild Cognitive Impairment
48/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of Alzheimer's disease : JAD
Key finding: In MCI subjects, the NCPT composite is significantly correlated with both a composite measure of established tests (r = 0.78, p < 0.0001) as well as with the ADAS-Cog (r = -0.55, p < 0.0001). +4 more findings
Full summary, score breakdown and related studies → Original source
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2022 year only
Digital Intervention for the Management of Alzheimer's Disease
41/100 ✓ Peer-reviewed Cognitive tests and assessment Current Alzheimer research
Key finding: Dtx provides evidence based therapeutic interventions driven by internet and software, employing tools such as mobile devices, computers, videogames, apps, sensors, virtual reality aiding in the prevention, management, and treatment of ailments like neurological abnormalities and chronic diseases. +4 more findings
Full summary, score breakdown and related studies → Original source
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2022 year only
The Use of Digital Technology to Assess Cognitive Function in Tunisian Adults
41/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of Alzheimer's disease : JAD
Key finding: The AD group performed significantly lower on the associative learning (p = 0.01) and associative memory assessments (p = 0.002), than the HC and AR groups. +4 more findings
Full summary, score breakdown and related studies → Original source
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2022 year only
Characteristics of Drawing Process Differentiate Alzheimer's Disease and Dementia with Lewy Bodies
48/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of Alzheimer's disease : JAD
Key finding: Reduced speed and reduced smoothness in speed and pressure were observed particularly in the LBD group, while increased pauses and total durations were observed in both the AD and LBD groups. +2 more findings
Full summary, score breakdown and related studies → Original source
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2022 year only
Distinct Patterns Link the BDNF Val66Met Polymorphism to Alzheimer's Disease Pathology
50/100 ✓ Peer-reviewed Tau biomarkers Journal of Alzheimer's disease : JAD
Key finding: We found distinct pathways to Alzheimer's disease pathology: Val-Met displayed lower CSF-Aβ42 in APOE ɛ4+ carriers, independent of p-tau, while Val-Val displayed greater p-tau at higher IL-6 and sub-threshold Aβ42.
Full summary, score breakdown and related studies → Original source
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2022 year only
Elecsys Cerebrospinal Fluid Assays Accurately Distinguish Alzheimer's Disease from Frontotemporal Lobar Degeneration
55/100 ✓ Peer-reviewed Tau biomarkers The journal of prevention of Alzheimer's disease
Key finding: AUC-based performance was similarly good for the pTau181/Aβ42 ratio (AUC=0.841; 95% CI: 0.759-0.923), pTau181/Aβ40 ratio (AUC=0.837; 95% CI: 0.754-0.919), Aβ42/Aβ40 ratio (AUC=0.829; 95% CI: 0.746-0.912), tTau/Aβ42 ratio (AUC=0.822; 95% CI: 0.736-0.908), pTau181/Aβ42/Aβ40 ratio (AUC=0.817; 95% CI: 0.734-0.901), and Aβ42 (AUC=0.812; 95% CI: 0.722-0.902). +4 more findings
Full summary, score breakdown and related studies → Original source
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2022 year only
A Blood Test for Alzheimer's Disease: It's about Time or Not Ready for Prime Time?
41/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD
Key finding: Standalone use, however, carries a significant risk of misinterpretation and is strongly discouraged.
Full summary, score breakdown and related studies → Original source
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2022 year only
Blood Tests for Alzheimer's Disease: Increasing Efforts to Expand and Diversify Research Participation Is Critical for Widespread Validation and Acceptance
41/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD
Key finding: The recent academic and commercial development, and regulatory approvals, of blood-based Alzheimer's disease (AD) biomarkers are breakthrough developments of immense potential. +3 more findings
Full summary, score breakdown and related studies → Original source
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2022 year only
Unravelling the Association Between Amyloid-PET and Cerebrospinal Fluid Biomarkers in the Alzheimer's Disease Spectrum: Who Really Deserves an A+?
52/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD
Key finding: Different pipelines gave highly inter-correlated standardized uptake value ratios (SUVRs) (rho = 0.93-0.99). +4 more findings
Full summary, score breakdown and related studies → Original source
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2022 year only
PSEN2 Mutation Spectrum and Novel Functionally Validated Mutations in Alzheimer's Disease: Data from PUMCH Dementia Cohort
48/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD
Key finding: Nine PSEN2 rare variants were found, including two reported (M239T, R62C) and seven novel variants (N141S, I368F, L396I, G117X, I146T, S147N, H220Y). +4 more findings
Full summary, score breakdown and related studies → Original source
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2022 year only
A Review of Application of Aβ42/40 Ratio in Diagnosis and Prognosis of Alzheimer's Disease
41/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD
Key finding: The amyloid cascade hypothesis attributes a vital role to amyloid-β protein (Aβ) in the pathogenesis of AD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2022 year only
Associations of Physical Activity with Alzheimer's Disease Pathologies and Cognition: The CABLE Study
61/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD
Key finding: Regular physical activity was positively associated with CSF Aβ42 (p < 0.001) and Aβ42/40 (p < 0.001), while it was negatively associated with p-tau/Aβ42 (p < 0.001) and t-tau/Aβ42 (p < 0.001). +4 more findings
Full summary, score breakdown and related studies → Original source
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2022 year only
Inflammation Disrupts Cognitive Integrity via Plasma Neurofilament Light Chain Coupling Brain Networks in Alzheimer's Disease
50/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD
Key finding: Discrimination of disease-related interactions of the core subsystem and FPN was found in AD-spectrum patients, which was the neural circuit fundamental to plasma NFL disrupting cognitive integrity. +2 more findings
Full summary, score breakdown and related studies → Original source
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2022 year only
A Combination of Neurofilament Light, Glial Fibrillary Acidic Protein, and Neuronal Pentraxin-2 Discriminates Between Frontotemporal Dementia and Other Dementias
54/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD
Key finding: CSF NPTX2 and serum GFAP levels varied most between diagnostic groups. +4 more findings
Full summary, score breakdown and related studies → Original source
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2022 year only
Relationship Between Plasma Neurofilament Light Chain, Gut Microbiota, and Dementia: A Cross-Sectional Study
66/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD
Key finding: We analyzed 128 participants (women: 59%, mean age: 74 years). +4 more findings
Full summary, score breakdown and related studies → Original source
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2022 year only
Plasma Neurofilament Light Chain and Clinical Diagnosis in Frontotemporal Dementia Syndromes
41/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD
Key finding: Fifty participants were studied: bvFTD = 20, semantic variant FTD (svFTD) = 11, non-fluent variant FTD (nfvFTD) = 9, FTD with motor neuron disease (MND) = 4, phFTD = 2, slow progressors = 3, FTD mimic = 1, mean age 67.2 (SD 8.4) years. +4 more findings
Full summary, score breakdown and related studies → Original source
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2022 year only
Long-Term Depression-Inducing Low Frequency Stimulation Enhances p-Tau181 and p-Tau217 in an Age-Dependent Manner in Live Rats
41/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD
Key finding: We found that LFS enhanced p-Tau181 and p-Tau217 in an age-dependent manner in the hippocampus of live rats. +4 more findings
Full summary, score breakdown and related studies → Original source
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2022 year only
Differences Between Plasma and Cerebrospinal Fluid p-tau181 and p-tau231 in Early Alzheimer's Disease
55/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD
Key finding: Plasma phosphorylated tau species have been recently proposed as peripheral markers of Alzheimer's disease (AD) pathology. +3 more findings
Full summary, score breakdown and related studies → Original source
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2022-01-01
Diabetes duration and the risk of dementia: a cohort study based on German health claims data
71/100 ✓ Peer-reviewed Digital health tools Age and ageing
Key finding: We identified a non-linear association of type 2 diabetes duration and the risk of dementia.
Full summary, score breakdown and related studies → Original source
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2022-01-01
Risk of Alzheimer's Disease Following Influenza Vaccination: A Claims-Based Cohort Study Using Propensity Score Matching
62/100 ✓ Peer-reviewed Digital health tools Journal of Alzheimer's disease : JAD
Key finding: This study demonstrates that influenza vaccination is associated with reduced AD risk in a nationwide sample of US adults aged 65 and older. +1 more finding
Full summary, score breakdown and related studies → Original source
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2022-01-01
Inflammation in obesity, diabetes, and related disorders
40/100 ✓ Peer-reviewed Risk factors Immunity
Key finding: We discuss how chronic tissue inflammation results in IR, impaired insulin secretion, glucose intolerance, and T2D and review the effect of inflammation on diabetic complications and on the relationship between T2D and other pathologies.
Full summary, score breakdown and related studies → Original source
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2022-01-01
Amyloid-Related Imaging Abnormalities and Other MRI Findings in a Cognitively Unimpaired Population With and Without Cerebral Amyloid
64/100 ✓ Peer-reviewed Treatments The journal of prevention of Alzheimer's disease
Key finding: ARIA-E is rare in cognitively unimpaired Aβ+ and Aβ- populations prior to anti-amyloid drug intervention. +3 more findings
Full summary, score breakdown and related studies → Original source
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