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Effect of computerized cognitive training on mood, cognition, and serum brain-derived neurotrophic factor level in late-life depression - a pilot randomized controlled trial
Suk Ling Ma, Katsie Tung Tang, Niki Cheuk Ting Lau, Clement Lek Hin Chiu, Cuichan Lin, Linda Chiu Wa Lam, Allen Ting Chun Lee. Frontiers in psychiatry, 2024-01-17
Topic: Brain imaging, connectivity and assessment
Our sample had a mean age of 66.8 (SD = 5.3) years, a mean HAM-D score of 19.4 (SD = 7.5), and a mean PHQ-9 score of 18.0 (SD = 6.3). No adverse effects were reported. Significant differences were observed between the experimental and control groups in changes in HAM-D (-8.4 vs. -2.9; group difference = -5.5; p = 0.01), PHQ-9 (-6.6 vs. -0.6; -6.0; p < 0.001), MoCA (1.4 vs. -1.3; 2.7; p = 0.001), and serum BDNF levels (in pg/ml; 2088.3 vs. -3277.4; 5365.6; p = 0.02). Additionally, changes in HAM-D, PHQ-9, and MoCA scores correlated significantly with changes in BDNF level. With computerized cognitive training improving mood and cognition and increasing serum BDNF levels in 6 weeks, it may serve as a safe and effective evidence-based alternative or adjuvant treatment for late-life depression. CLINICAL TRIAL REGISTRATION: https://www.chictr.org.cn/indexEN.html, identifier ChiCTR1900027029.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Ma, S. L., Tang, K. T., Lau, N. C. T., Chiu, C. L. H., Lin, C., Lam, L. C. W., et al. (2023). Effect of computerized cognitive training on mood, cognition, and serum brain-derived neurotrophic factor level in late-life depression - a pilot randomized controlled trial. Frontiers in psychiatry. https://doi.org/10.3389/fpsyt.2023.1287822
Vancouver
Ma SL, Tang KT, Lau NCT, Chiu CLH, Lin C, Lam LCW, et al. Effect of computerized cognitive training on mood, cognition, and serum brain-derived neurotrophic factor level in late-life depression - a pilot randomized controlled trial. Frontiers in psychiatry. 2023. doi:10.3389/fpsyt.2023.1287822. PMID: 38298930.
BibTeX
@article{ma2023-38298930,
author = {Ma, Suk Ling and Tang, Katsie Tung and Lau, Niki Cheuk Ting and Chiu, Clement Lek Hin and Lin, Cuichan and Lam, Linda Chiu Wa and Lee, Allen Ting Chun},
title = {{Effect of computerized cognitive training on mood, cognition, and serum brain-derived neurotrophic factor level in late-life depression - a pilot randomized controlled trial}},
journal = {Frontiers in psychiatry},
year = {2023},
doi = {10.3389/fpsyt.2023.1287822},
pmid = {38298930},
url = {https://doi.org/10.3389/fpsyt.2023.1287822}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Our sample had a mean age of 66.8 (SD = 5.3) years, a mean HAM-D score of 19.4 (SD = 7.5), and a mean PHQ-9 score of 18.0 (SD = 6.3).
- Significant differences were observed between the experimental and control groups in changes in HAM-D (-8.4 vs. -2.9; group difference = -5.5; p = 0.01), PHQ-9 (-6.6 vs. -0.6; -6.0; p < 0.001), MoCA (1.4 vs. -1.3; 2.7; p = 0.001), and serum BDNF levels (in pg/ml; 2088.3 vs. -3277.4; 5365.6; p = 0.02).
- Additionally, changes in HAM-D, PHQ-9, and MoCA scores correlated significantly with changes in BDNF level.
- With computerized cognitive training improving mood and cognition and increasing serum BDNF levels in 6 weeks, it may serve as a safe and effective evidence-based alternative or adjuvant treatment for late-life depression.
- CLINICAL TRIAL REGISTRATION: https://www.chictr.org.cn/indexEN.html, identifier ChiCTR1900027029.
Study details
- Study designrandomized controlled trial
- Participants28
- Evidence strengthHigh
How this study scored 77/100
Published in a peer-reviewed journal, and it is a randomised controlled trial. Scored zero for effect reported because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 43 of the 56 points we could judge it on, which is 77 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Frontiers in psychiatry) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 11 / 12 | A randomised controlled trial |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 1 / 4 | 28 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 1 / 2 | Randomised (as stated in the record) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 38298930) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 43 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 43 of the 56 points we could judge it on is 77 out of 100. |
| Total | 77 / 100 | — |
What each of these 20 components measures, and what this score is not →
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