Newest studies

CSF complement proteins are associated with early tau pathology and synaptic damage in an asymptomatic population at risk of Alzheimer’s disease

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging bioRxiv

Key finding: In the PREVENT-AD cohort of cognitively unimpaired individuals at increased familial risk of AD, we investigated whether CSF complement proteins relate to early AD pathology and synaptic dysfunction, then assessed our results’ reproducibility across the clinical AD spectrum. +3 more findings

• Brain Biology
• Biomarkers
• Brain Scans

Scored 32 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Absorption and Co-expression Modules Show Where Polygenic and Proteomic Risk Scores Diverge in Neurodegenerative Diseases

16/100 ⚠ Preprint — not yet peer-reviewed Genetics medRxiv (preprint)

Key finding: The proteins associated with a polygenic score and the proteins a proteomic score selects overlap no more often than chance, converging only where APOE dominates. +2 more findings

• Genetics

Scored 22 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Explainable Deep Learning Reveals Distributed Neurodegeneration Signatures of Neuropsychiatric Symptoms Across the Alzheimer's Continuum

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging medRxiv (preprint)

Key finding: The NPSNet strongly predicted NPS scores (pooled Spearman{rho} = 0.927, p < 2.2 x 10-3; fold-wise{rho} = 0.912 - 0.963) and NPSNetSHAP recovered all 100% perturbed regions, compared with 90% for NPSNetLIME and 40% for NPSNetLRP. +1 more finding

• Digital Tools
• Early Stage

Scored 28 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Fine-mapping HLA-II haplotypes in Alzheimer's disease and healthy longevity reveals distinct associations with microglial HLA-II load and neuropathology

16/100 ⚠ Preprint — not yet peer-reviewed How common it is medRxiv (preprint)

Key finding: Hap-B (DRB1*04 subtypes) was protective, enriched in CHCs and controls versus AD, with its neuroprotective association with tau pathology replicated in an independent Netherlands Brain Bank cohort. +1 more finding

• Brain Biology

Scored 29 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Adult Vaccination History and Plasma Biomarker Signatures in the Asymptomatic PREVENT-AD Cohort

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv (preprint)

Key finding: BackgroundEpidemiological studies increasingly associate several adult vaccinations with lower risk of Alzheimers disease (AD) and dementia, but the biological mechanisms underlying these observations remain unclear. +4 more findings

• Biomarkers
• Prevention

Scored 34 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Integrating cognitive, linguistic and acoustic features to identify individuals with cognitive impairment: a proof-of-concept study

16/100 ⚠ Preprint — not yet peer-reviewed Getting a diagnosis medRxiv (preprint)

Key finding: Across multiple machine learning models, combining cognitive, acoustic and linguistic features yielded significantly better classification performance than models using cognitive or speech features alone (area under the curve = 0.96-0.98, both comparisons p < .05).

• Diagnosis
• Early Stage

Scored 20 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Aspirin and healthy longevity within racial and ethnic minoritized older adults in the United States

16/100 ⚠ Preprint — not yet peer-reviewed Treatments medRxiv (preprint)

Key finding: ImportanceThe ASPREE randomized trial found no overall benefit of low-dose aspirin for disability-free survival among older adults. +3 more findings

• Health Equity
• Clinical Trials

Scored 41 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Temporal progression of auditory brainstem dysfunction and behavioral phenotypes in mouse models of tauopathy

34/100 ✓ Peer-reviewed Disease mechanisms Journal of Neuroscience

Key finding: The PS19 mouse model expressing the P301S tau mutation exhibits tau pathology associated with frontotemporal dementia. +4 more findings

• Brain Biology
• Genetics

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Terapia anti β-amiloide y enfermedad cerebrovascular: nuevos retos para la neurología vascular

27/100 ✓ Peer-reviewed Treatments Acta neurológica colombiana

Key finding: Aunque suelen ser hallazgos radiológicos, pueden ocasionar déficits neurológicos focales, crisis epilépticas, cefalea o encefalopatía, síntomas que pueden confundirse con eventos cerebrovasculares agudos. +4 more findings

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The Joint Effects of Life’s Essential 8 and Genetics on Mild Cognitive Impairment and Dementia Risk in People With Diabetes: Findings From the UK Biobank and All of Us

42/100 ✓ Peer-reviewed Genetics Diabetes Care

Key finding: Over 15 years of follow-up (UKB), moderate or high CVH versus low CVH was associated with a lower risk of MCI (hazard ratio 0.82 [95% CI 0.71, 0.95], P < 0.05) but not with risk of all-cause dementia (0.97 [0.84, 1.11], P = 0.63). +3 more findings

• Risk Factors
• Genetics
• Early Stage

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A multiancestry polygenic risk score for Alzheimer's disease is associated with cognitive decline and neuropathological hallmarks in diverse populations

56/100 ✓ Peer-reviewed Genetics Nature genetics

Key finding: The PRS was significantly associated with AD in European ancestry, African American, Caribbean Hispanic and Native American Hispanic groups with adjusted odds ratios between 1.14 and 1.52 per PRS standard deviation. +2 more findings

• Genetics
• Brain Biology

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Auditory brainstem response latencies, but not amplitudes, are associated with gray matter volumes across the human auditory pathway in older adults

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors bioRxiv

Key finding: ABR latencies, rather than amplitudes, showed significant associations with regional gray matter volumes. +4 more findings

Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Low-dose lithium prevents age-dependent metabolic stress–driven alzheimer’s disease–like pathology through restoration of the NAMPT–NAD⁺–SIRT1–AMPK–TFEB metabolic resilience network

16/100 ⚠ Preprint — not yet peer-reviewed Drug development Research Square

Key finding: These findings identify an age-dependent breakdown of the metabolic resilience network formed by NAMPT, NAD⁺, SIRT1, and AMPK as a key mechanistic driver of metabolic stress-induced early AD-like pathology. +2 more findings

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Real-world evidence for amyloid-targeted therapies: Lecanemab and donanemab

63/100 ✓ Peer-reviewed Treatments Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Amyloid-related imaging abnormalities (ARIA) occurred in 11.2% (10/89) with lecanemab and 13.3% (11/83) with donanemab-less than in pivotal trials. +4 more findings

• Treatments
• Side Effects
• Brain Scans

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Multimodal Transformer Modeling of Rapamycin Treatment in Alzheimer's Disease via Random Forest Feature Filtering

16/100 ⚠ Preprint — not yet peer-reviewed How common it is medRxiv (preprint)

Key finding: Rapamycin, an FDA-approved inhibitor of the mammalian target of rapamycin (mTOR) pathway, has demonstrated promising anti-aging and neuroprotective effects. +3 more findings

• Treatments

Scored 29 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Discordance Between Genetic Ancestry and Self-Reported Race Impacts Inference of Neuropsychiatric Burden in Alzheimer's Disease

16/100 ⚠ Preprint — not yet peer-reviewed How common it is medRxiv (preprint)

Key finding: Genetic ancestry was inferred by principal component clustering, identifying six groups (EUR, AFR, EAS, SAS, AMR, ADMIXED), and compared with self-reported race/ethnicity.

• Genetics

Scored 23 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Perceptions of non-invasive brain stimulation and barriers to it's clinical translation: a multi-stakeholder focus group study

16/100 ⚠ Preprint — not yet peer-reviewed Risk genes beyond APOE medRxiv (preprint)

Key finding: ObjectivesNon-invasive brain stimulation (NIBS) holds significant promise for treating neurological and neuropsychiatric conditions, yet translation into routine clinical practice remains limited.

• Policy

Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Dementia Diagnosis Underreporting and Care Engagement and Planning Among Older Adults

47/100 ✓ Peer-reviewed Health systems and care delivery JAMA Network Open

Key finding: Among 6158 person-waves with a claims-based dementia diagnosis from 3278 PWPD (3134 [50.9%] aged 65-84 years; 4282 [69.5%] female; 1176 [19.1%] non-Hispanic Black, 617 [10.0%] Hispanic, and 4256 [69.1%] non-Hispanic White), the adjusted proportion not reporting their diagnosis was 42% (95% CI, 40%-43%) among all respondents and 67% (95% CI, 64%-69%) among self-respondents. +4 more findings

• Diagnosis

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Exome analysis of 22,319 individuals links extremely rare copy-number variants and 22q11.21 dosage to Alzheimer risk

57/100 ✓ Peer-reviewed Genetics American Journal of Human Genetics

Key finding: SCARF2 overexpression significantly increased amyloid-β uptake, congruent with duplication-associated decreased AD risk. +1 more finding

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Cognitive Performance in Spouses of Individuals with Alzheimer’s Disease: A Controlled Cross-Sectional Study

16/100 ⚠ Preprint — not yet peer-reviewed Cognitive tests and assessment Research Square

Key finding: These findings indicate modestly lower cognitive performance, particularly in word-finding and praxis-related tasks, but do not establish cognitive decline, causality, or Alzheimer’s disease in spouses.

• Diagnosis
• Caregiving

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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A gFET-based Sensor Equipped with a Focused Post-SELEX Aptamer Library for Specific Quantification of the Hormone-like Anti-Aging Protein Klotho in Human Serum

16/100 ⚠ Preprint — not yet peer-reviewed How common it is Research Square

Key finding: In humans, reduced Klotho expression is associated with aging, diabetes, Alzheimer’s disease and other age-related disorders, correlating with increased all-cause mortality.

• Digital Tools

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Spoken Recall Reveals Lexical and Mnemonic Function Differences in Temporal Lobe Epilepsy Patients

16/100 ⚠ Preprint — not yet peer-reviewed Digital health tools bioRxiv

Key finding: We examined whether natural language processing and acoustic analysis of spoken biographical recall could identify lexical and temporal speech features associated with language and memory performance in TLE. +4 more findings

Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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How Much Non-response Matters? Diagnosis Prevalence Estimates in Survey Participants Versus the Total Sample

16/100 ⚠ Preprint — not yet peer-reviewed Costs and economics Research Square

Key finding: In this setting, selective participation had only a limited effect on prevalence estimates after weighting. +1 more finding

• Diagnosis

Scored 32 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Chronic trazodone treatment consolidates sleep, improves memory, and reduces amyloid pathology in a mouse model of Alzheimer’s disease

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors bioRxiv

Key finding: Chronic trazodone treatment was also associated with better short-term and long-term recognition memory. +1 more finding

• Treatments
• Brain Biology
• Lifestyle

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Amyloid and Tau Cerebrospinal Fluid Biomarker Normalization in a Patient with Alzheimer’s Disease treated with Lecanemab: A Case Report

16/100 ⚠ Preprint — not yet peer-reviewed Treatments Research Square

Key finding: CSF Aβ42 rose from 526.0 to 1053.0 pg/mL (+ 100.2%), total tau (t-tau) fell from 578.2 to 278.0 pg/mL(-51.9%), and phosphorylated tau181 (p-tau181) fell from 90.8 to 23.1 pg/mL(-74.6%). +1 more finding

• Treatments
• Biomarkers

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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