Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 19,401–19,425 of 27,380 studies, newest first · page 777 of 1096.
June 2012 25
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2012-06-14
Therapeutic Seal Robot as Biofeedback Medical Device: Qualitative and Quantitative Evaluations of Robot Therapy in Dementia Care
34/100 ✓ Peer-reviewed Digital health tools Proceedings of the IEEE
Key finding: Recent research has revealed that robot therapy has a similar effect on patients as animal therapy.
Full summary, score breakdown and related studies → Original source
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2012-06-14
Aging in correctional custody: setting a policy agenda for older prisoner health care
36/100 ✓ Peer-reviewed End-of-life care American journal of public health
Key finding: An exponential rise in the number of older prisoners is creating new and costly challenges for the criminal justice system, state economies, and communities to which older former prisoners return. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-06-14
FLAIR and diffusion MRI signals are independent predictors of white matter hyperintensities
52/100 ✓ Peer-reviewed Brain scans and imaging AJNR. American journal of neuroradiology
Key finding: Stepwise decreases in WM integrity as measured by both DTI and FLAIR were independently associated with stepwise increases in WMH risk, emphasizing that these modalities may provide complementary information for understanding the time course of aging-associated WM degeneration. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-06-13
Mitochondrial dysfunction in neurodegenerative diseases
36/100 ✓ Peer-reviewed Disease mechanisms The Journal of pharmacology and experimental therapeutics
Key finding: Neurodegenerative diseases are a large group of disabling disorders of the nervous system, characterized by the relative selective death of neuronal subtypes. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-06-13
Low PiB PET retention in presence of pathologic CSF biomarkers in Arctic APP mutation carriers
49/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: The lack of fibrillar β-amyloid (Aβ) as visualized by PiB PET in APParc mutation carriers suggests, given the reduced glucose metabolism and levels of Aβ(1-42) in CSF, that other forms of Aβ such as oligomers and protofibrils are important for the pathologic processes leading to clinical Alzheimer disease. +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-06-12
Reduced hippocampal volume and verbal memory performance associated with interleukin-6 and tumor necrosis factor-alpha levels in chemotherapy-treated breast cancer survivors
43/100 ✓ Peer-reviewed Hippocampus size on brain scans Brain, behavior, and immunity
Key finding: Many survivors of breast cancer show significant cognitive impairments, including memory deficits. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-06-12
The Montreal Cognitive Assessment is superior to the Mini-Mental State Examination in detecting patients at higher risk of dementia
49/100 ✓ Peer-reviewed Cognitive tests and assessment International psychogeriatrics
Key finding: Memory clinic patients were administered the MoCA, MMSE, and a comprehensive formal neuropsychological battery. +3 more findings
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2012-06-12
The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo
48/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: However, the function and the physiological substrates of BACE1 remain largely unknown. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-06-12
The incidence and prevalence of Huntington's disease: a systematic review and meta-analysis
62/100 ✓ Peer-reviewed How common it is Movement disorders : official journal of the Movement Disorder Society
Key finding: Meta-analysis of data from four incidence studies revealed an incidence of 0.38 per 100,000 per year (95% confidence interval [CI]: 0.16, 0.94). +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-06-12
The somatic comorbidity of epilepsy: a weighty but often unrecognized burden
47/100 ✓ Peer-reviewed Prevention and risk Epilepsia
Key finding: The presence of somatic disorders in epilepsy is associated with increased health care needs, poorer health-related quality of life, and premature mortality.
Full summary, score breakdown and related studies → Original source
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2012-06-11
Disruption of functional brain networks in Alzheimer's disease: what can we learn from graph spectral analysis of resting-state magnetoencephalography?
40/100 ✓ Peer-reviewed Brain scans and imaging Brain connectivity
Key finding: Graph spectral analysis (GSA) is a more direct algebraic method that describes network properties, which might lead to more reliable results. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-06-09
The impact of family caregivers on potentially inappropriate medication use in noninstitutionalized older adults with dementia
57/100 ✓ Peer-reviewed Disparities The American journal of geriatric pharmacotherapy
Key finding: PIM use may be higher in dementia patients and their informal caregivers compared with the general older adult population. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-06-09
Critical review: vegetables and fruit in the prevention of chronic diseases
53/100 ✓ Peer-reviewed Prevention and risk European journal of nutrition
Key finding: For hypertension, CHD, and stroke, there is convincing evidence that increasing the consumption of vegetables and fruit reduces the risk of disease. +4 more findings
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2012-06-08
Montreal Cognitive Assessment (MoCA): validation study for vascular dementia
42/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of the International Neuropsychological Society : JINS
Key finding: The aim of the present study was to validate the MoCA as well as its short version, which was proposed by the NINDS-CSN VCI Harmonization Standards for screening Vascular Dementia (VaD) patients. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-06-08
Prevalence of dementia and major dementia subtypes in the Chinese populations: a meta-analysis of dementia prevalence surveys, 1980-2010
50/100 ✓ Peer-reviewed Disparities Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
Key finding: The prevalence of VaD was significantly higher in Northern China than in Southern China. +1 more finding
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2012-06-07
Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants
69/100 ✓ Peer-reviewed Genetics PLoS genetics
Key finding: We identified 2,980 cerebellar cisSNP/transcript level associations (2,596 unique cisSNPs) significant in both ADs and non-ADs (q<0.05, p=7.70 × 10(-5)-1.67 × 10(-82)). +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-06-06
The problems of vitamin d insufficiency in older people
36/100 ✓ Peer-reviewed Clinical safety Aging and disease
Key finding: Non-classical effects of vitamin D, depending on serum circulating 25-hydroxyvitamin D concentrations, are present in most non-bony tissues; disorders associated with hypovitaminosis D include increased risks of sepsis [bacterial, mycobacterial and viral], cardiovascular and metabolic disorders [e.g. hyperlipidemia, type 2 diabetes mellitus, acute vascular events, dementia, stroke and heart failure]. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-06-05
Safety and biomarker effects of solanezumab in patients with Alzheimer's disease
76/100 ✓ Peer-reviewed Treatments Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Antibody administration was well tolerated with doses up to 400 mg weekly. +1 more finding
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2012-06-05
Identification of Alzheimer disease-associated variants in genes that regulate retromer function
47/100 ✓ Peer-reviewed Risk genes beyond APOE Neurobiology of aging
Key finding: The endocytic system mediates the processing of APP by controlling its access to secretases that cleave APP. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-06-04
Mitochondria, oxidative stress and neurodegeneration
36/100 ✓ Peer-reviewed Disease mechanisms Journal of the neurological sciences
Key finding: Many rare metabolic disorders have been associated with mitochondrial dysfunction.
Full summary, score breakdown and related studies → Original source
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2012-06-04
Resting-state brain functional connectivity is altered in type 2 diabetes
50/100 ✓ Peer-reviewed Brain scans and imaging Diabetes
Key finding: Control subjects showed stronger correlations versus T2DM patients in the DMN between the seed (posterior cingulate) and bilateral middle temporal gyrus (β = 0.67 vs. 0.43), the right inferior and left medial frontal gyri (β = 0.75 vs. 0.54), and the left thalamus (β = 0.59 vs. 0.37), respectively, with no group differences in cognition or hippocampal size. +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-06-04
Education and dementia in the context of the cognitive reserve hypothesis: a systematic review with meta-analyses and qualitative analyses
73/100 ✓ Peer-reviewed Prevention and risk PloS one
Key finding: This systematic review and meta-analyses covering a wide range of observational studies and diverse settings provides robust support for the CR hypothesis. +4 more findings
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2012-06-02
Stress abnormalities in individuals at risk for psychosis: a review of studies in subjects with familial risk or with "at risk" mental state
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Psychoneuroendocrinology
Key finding: On the other hand, subjects who experience attenuated psychotic symptoms show increased cortisol levels as well as increased pituitary and reduced hippocampal volumes. +4 more findings
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2012-06-01
Alzheimer's disease and environmental exposure to lead: the epidemiologic evidence and potential role of epigenetics
40/100 ✓ Peer-reviewed Risk factors Current Alzheimer research
Key finding: Several lines of evidence indicate that the etiology of late-onset Alzheimer's disease (LOAD) is complex, with significant contributions from both genes and environmental factors. +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-06-01
Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease
36/100 ✓ Peer-reviewed Treatments Cold Spring Harbor perspectives in medicine
Key finding: Progressive cerebral deposition of the amyloid β-protein (Aβ) in brain regions serving memory and cognition is an invariant and defining feature of Alzheimer disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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