Newest studies

APOE4 Increases Energy Metabolism in APOE-Isogenic iPSC-Derived Neurons

43/100 ✓ Peer-reviewed Genetics Cells

Key finding: We showed that endogenously produced APOE4 enhanced mitochondrial ATP production in APOE-isogenic iN cells but not in the corresponding iPS cell line. +1 more finding

• Genetics
• Brain Biology

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Plasma p-tau217 concordance with amyloid PET among ethnically diverse older adults

59/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: A total of 239 participants underwent blood draw and Aβ-PET (age 70.8 ± 7.8, 55.2% female, education 15.6 ± 3.4 years, 48.9% Hispanic/Latino, 94.9% white). +4 more findings

• Biomarkers
• Health Equity
• Brain Scans

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Factors associated with Alzheimer's Disease Dementia prevalence in the United States: A county-level spatial machine learning analysis

33/100 ✓ Peer-reviewed Risk factors Not indexed

Key finding: The model outperformed conventional ones, with an out-of-bag R2 of 74.8%. +2 more findings

• Digital Tools

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The Inflammasome Adaptor Protein ASC in Plasma as a Biomarker of Early Cognitive Changes

43/100 ✓ Peer-reviewed Biomarkers International journal of molecular sciences

Key finding: ASC was elevated in the plasma of the NI group compared to the NN and II groups. +1 more finding

• Biomarkers

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Insulin resistance as the molecular link between diabetes and Alzheimer's disease

43/100 ✓ Peer-reviewed Risk factors World journal of diabetes

Key finding: Recent studies have indicated a possible link between DM and an increased risk of developing AD. +2 more findings

• Risk Factors
• Brain Biology

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Bibliometric analysis of neuroinflammation and Alzheimer's disease

58/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in aging neuroscience

Key finding: This study provides a comprehensive review of the last 10 years of research on neuroinflammation and AD, including the number and impact of research findings, research hotspots, and future trends. +1 more finding

• Brain Biology

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A pathologic study of Perivascular pTDP-43 Lin bodies in LATE-NC

43/100 ✓ Peer-reviewed Brain tissue and pathology Acta neuropathologica communications

Key finding: As shown previously, there was a robust association between Lin bodies and GFAP-positive astrocyte processes. +4 more findings

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Targeting Microglia in Alzheimer's Disease: Pathogenesis and Potential Therapeutic Strategies

43/100 ✓ Peer-reviewed Genetics Biomolecules

Key finding: Recent advances in single-cell RNA sequencing (scRNA-seq) and single-nucleus RNA sequencing (snRNA-seq) have revealed dynamic changes in microglial phenotypes over time and across different brain regions during aging and AD progression.

• Brain Biology
• Treatments

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12-month neurological and psychiatric outcomes of semaglutide use for type 2 diabetes: a propensity-score matched cohort study

77/100 ✓ Peer-reviewed Drug development EClinicalMedicine

Key finding: Each matched cohort included 23,386 (semaglutide vs sitagliptin), 22,584 (vs empagliflozin), and 19,206 (vs glipizide) patients. +4 more findings

• Treatments
• Risk Factors

Full summary, score breakdown and related studies → Original source

Single cell transcriptomes and multiscale networks from persons with and without Alzheimer's disease

46/100 ✓ Peer-reviewed Genetics Nature communications

Key finding: We observed an AD-associated CD83(+) microglial subtype with unique molecular networks and which is associated with immunoglobulin IgG4 production in the transverse colon. +1 more finding

• Genetics

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Apolipoprotein E polymorphisms and female fertility in a transgenic mouse model of Alzheimer's disease

43/100 ✓ Peer-reviewed Genetics Scientific reports

Key finding: In conclusion, APOE genotypes impact fertility and pregnancy outcomes in female mice, in concordance with findings in human populations.

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Multiplex cerebrospinal fluid proteomics identifies biomarkers for diagnosis and prediction of Alzheimer's disease

52/100 ✓ Peer-reviewed Long-term cohort studies Nature human behaviour

Key finding: Among 6,361 cerebrospinal fluid (CSF) proteins analysed from the ADNI database, YWHAG performed best in diagnosing both biologically (AUC = 0.969) and clinically (AUC = 0.857) defined AD. +3 more findings

• Biomarkers
• Diagnosis

Full summary, score breakdown and related studies → Original source

Spatial extent as a sensitive amyloid-PET metric in preclinical Alzheimer's disease

48/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: These findings indicate EXT may be more sensitive to Aβ's role in preclinical AD than level and improve targeting of individuals for AD prevention trials. +1 more finding

• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Predicting Cognitive Decline in Amyloid-Positive Patients With Mild Cognitive Impairment or Mild Dementia

63/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: We constructed models for MCI and mild dementia that predict MMSE over time.

• Biomarkers
• Early Stage
• Brain Scans

Full summary, score breakdown and related studies → Original source

Blood Astrocyte Biomarkers in Alzheimer Disease: A Systematic Review and Meta-Analysis

72/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: We demonstrated significant elevations in blood GFAP and YKL-40 levels in patients on the AD continuum compared with CU individuals. +4 more findings

• Biomarkers
• Brain Biology
• Early Stage

Full summary, score breakdown and related studies → Original source

Blood-Brain Barrier Permeability Is Associated With Cognitive Functioning in Normal Aging and Neurodegenerative Diseases

52/100 ✓ Peer-reviewed Vascular contributions Journal of the American Heart Association

Key finding: A total of 124 participants with Alzheimer disease, cerebrovascular disease, or a mix Alzheimer's and cerebrovascular diseases and 55 controlparticipants underwent magnetic resonance imaging and neuropsychological testing. +4 more findings

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Hearing Screening for Older Adults With Cognitive Impairment: A Systematic Review

82/100 ✓ Peer-reviewed Risk factors Journal of audiology & otology

Key finding: Electrophysiological and behavioral tests demonstrated strong correlation and accurate hearing impairment detection compared to PTA. +2 more findings

• Diagnosis

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Identification of retinal oligomeric, citrullinated, and other tau isoforms in early and advanced AD and relations to disease status

54/100 ✓ Peer-reviewed Brain scans and imaging Acta neuropathologica

Key finding: Retinal cross-sections from predefined superior-temporal and inferior-temporal subregions and corresponding brains from neuropathologically confirmed AD patients with a clinical diagnosis of either mild cognitive impairment (MCI) or dementia (n = 45) were compared with retinas from age- and sex-matched individuals with normal cognition (n = 30) and non-AD dementia (n = 4). +4 more findings

• Brain Biology

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Volumetric and functional connectivity changes of the thalamic nuclei in different stages of Alzheimer's disease

43/100 ✓ Peer-reviewed Brain scans and imaging Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

Key finding: In the course of AD, the volume of the medial group nuclei, especially the mediodorsal medial magnocellular (MDm) nucleus, decreases. +3 more findings

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Mapping the impact of age and APOE risk factors for late onset Alzheimer's disease on long range brain connections through multiscale bundle analysis

38/100 ✓ Peer-reviewed Risk factors Brain structure & function

Key finding: We found that the third level subdivision in the bundle hierarchy provided the most sensitive ability to detect age and genotype differences associated with risk factors. +2 more findings

• Risk Factors
• Genetics

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Cognition and Activity of Daily Living Function in people with Parkinson's disease

50/100 ✓ Peer-reviewed Prevention trials Journal of neural transmission (Vienna, Austria : 1996)

Key finding: This narrative review summarizes the current state of knowledge on the association of cognition and ADL function in people with PD and introduces the concept of "cognitive ADL" impairment for those problems in everyday life that are associated with cognitive deterioration as their primary cause. +1 more finding

• Clinical Trials
• Other Dementias

Full summary, score breakdown and related studies → Original source

Medicare expenditures among spouses of persons with dementia

47/100 ✓ Peer-reviewed Costs and economics Journal of the American Geriatrics Society

Key finding: Despite the differences in partner's dementia status, we found no significant difference in the 5-year cumulative Medicare expenditures between SPWD and SPWND. +4 more findings

• Policy
• Caregiving

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Editorial: On the 2024 Alzheimer's Association Criteria: Still Not Ready for Clinical Use

37/100 ✓ Peer-reviewed Getting a diagnosis The Journal of Prevention of Alzheimer's Disease

Key finding: Many people with amyloid buildup never develop dementia, so biomarker-only diagnosis risks over-labeling +3 more findings

• Diagnosis

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Single-cell resolution characterization of myeloid-derived cell states with implication in cancer outcome

51/100 ✓ Peer-reviewed TREM2 and immune genetics Nature communications

Key finding: Here, we integrate single-cell RNA-sequencing data from different cancer types, identifying 29 MDC subpopulations within the tumor microenvironment. +3 more findings

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PAHs as environmental pollutants and their neurotoxic effects

43/100 ✓ Peer-reviewed Risk factors Comparative biochemistry and physiology. Toxicology & pharmacology : CBP

Key finding: Polycyclic aromatic hydrocarbons (PAHs), which are widely present in incompletely combusted air particulate matter <2.5 μm (PM2.5), tobacco and other organic materials, can enter the human body through various routes and are a class of environmental pollutants with neurotoxic effects. +4 more findings

• Brain Biology

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