Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 18,876–18,900 of 27,380 studies, newest first · page 756 of 1096.
February 2013 25
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2013-02-11
Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy
51/100 ✓ Peer-reviewed Lewy body dementia Proceedings of the National Academy of Sciences of the United States of America
Key finding: Glial proliferation and activation are associated with disease progression in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-02-09
Pesticides and human chronic diseases: evidences, mechanisms, and perspectives
36/100 ✓ Peer-reviewed Risk factors Toxicology and applied pharmacology
Key finding: Along with the wide use of pesticides in the world, the concerns over their health impacts are rapidly growing. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-02-08
γ-Secretase modulator (GSM) photoaffinity probes reveal distinct allosteric binding sites on presenilin
44/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: Aβ42) that have been implicated in the pathogenesis of Alzheimer disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-02-08
Ferulic acid is a nutraceutical β-secretase modulator that improves behavioral impairment and alzheimer-like pathology in transgenic mice
47/100 ✓ Peer-reviewed Risk genes beyond APOE PloS one
Key finding: Recent AD therapeutic interest has been directed toward a group of anti-amyloidogenic compounds extracted from plants. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-02-08
Brain amyloid imaging
38/100 ✓ Peer-reviewed Brain scans and imaging Journal of nuclear medicine technology
Key finding: Imaging of brain β-amyloid plaques with (18)F-labeled tracers for PET will likely be available in clinical practice to assist the diagnosis of Alzheimer disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-02-07
Early Alzheimer's and Parkinson's disease pathology in urban children: Friend versus Foe responses--it is time to face the evidence
40/100 ✓ Peer-reviewed Risk factors BioMed research international
Key finding: The accumulation of misfolded proteins coincides with the anatomical distribution observed in the early stages of both Alzheimer's and Parkinson's diseases. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-02-07
The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS
59/100 ✓ Peer-reviewed Lewy body dementia Science (New York, N.Y.)
Key finding: Here, we found that most of these characteristic inclusions contain poly-(Gly-Ala) and, to a lesser extent, poly-(Gly-Pro) and poly-(Gly-Arg) dipeptide-repeat proteins presumably generated by non-ATG-initiated translation from the expanded GGGGCC repeat in three reading frames. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-02-06
Hospitalization and cognitive decline: Can the nature of the relationship be deciphered?
36/100 ✓ Peer-reviewed Clinical safety The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: There is evidence to support an association between hospitalization and development of cognitive decline.
Full summary, score breakdown and related studies → Original source
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2013-02-06
The association between physical activity and dementia in an elderly population: the Rotterdam Study
53/100 ✓ Peer-reviewed Long-term cohort studies European journal of epidemiology
Key finding: It remains unclear whether physical activity also affects dementia during longer follow-up. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-02-06
Prediction of dementia in MCI patients based on core diagnostic markers for Alzheimer disease
55/100 ✓ Peer-reviewed Mild cognitive impairment Neurology
Key finding: When patients with MCI underwent clinical follow-up, 29 progressed to dementia, while 44 remained stable. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-02-06
The association of neuropsychiatric symptoms in MCI with incident dementia and Alzheimer disease
68/100 ✓ Peer-reviewed Mild cognitive impairment The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: Neuropsychiatric symptoms in MCI are associated with significantly an increased risk of incident dementia and AD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-02-06
Alzheimer disease in the United States (2010-2050) estimated using the 2010 census
77/100 ✓ Peer-reviewed Getting a diagnosis Neurology
Key finding: The number of people in the United States with AD dementia will increase dramatically in the next 40 years unless preventive measures are developed.
Full summary, score breakdown and related studies → Original source
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2013-02-06
Mental and physical activities delay cognitive decline in older persons with dementia
62/100 ✓ Peer-reviewed Prevention and risk The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: Mahjong and TC can preserve functioning or delay decline in certain cognitive domains, even in those with significant cognitive impairment. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-02-06
"Thinking about it for somebody else": Alzheimer's disease research and proxy decision makers' translation of ethical principles into practice
50/100 ✓ Peer-reviewed Treatments The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: Tensions exist between abstract ethical principles regarding decision-making "standards" and their translation into research decisions. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-02-06
The peaceful mind program: a pilot test of a cognitive-behavioral therapy-based intervention for anxious patients with dementia
62/100 ✓ Peer-reviewed Treatments The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: Feasibility was demonstrated with regard to recruitment, attrition, and treatment characteristics. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-02-06
Neuropsychiatric symptoms as risk factors for progression from CIND to dementia: the Cache County Study
53/100 ✓ Peer-reviewed Genetics The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: These data confirm that NPS are risk factors for conversion from CIND to dementia.
Full summary, score breakdown and related studies → Original source
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2013-02-05
Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1
46/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: The cellular prion protein (PrP(C)) was recently identified as a high affinity neuronal receptor for Aβ oligomers. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-02-05
TREM2 is associated with the risk of Alzheimer's disease in Spanish population
53/100 ✓ Peer-reviewed Genetics Neurobiology of aging
Key finding: Here, we report the first positive replication study in a Spanish population and confirm that TREM2 rs75932628-T is associated with the risk for AD.
Full summary, score breakdown and related studies → Original source
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2013-02-04
ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43
53/100 ✓ Peer-reviewed Lewy body dementia Proceedings of the National Academy of Sciences of the United States of America
Key finding: Two ALS-causing mutants (TDP-43(Q331K) and TDP-43(M337V)), but not wild-type human TDP-43, are shown here to provoke age-dependent, mutant-dependent, progressive motor axon degeneration and motor neuron death when expressed in mice at levels and in a cell type-selective pattern similar to endogenous TDP-43. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-02-01
Study of the use of antidepressants for depression in dementia: the HTA-SADD trial – a multicentre, randomised, double-blind, placebo-controlled trial of the clinical effectiveness and cost-effectiveness of sertraline and mirtazapine
16/100 ⚠ Report — not peer-reviewed Costs and economics Health Technology Assessment
Key finding: Randomisation: Allocated 1 : 1 : 1 through Trials Unit, independently of trial team. +4 more findings
Scored 53 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2013-02-01
Review: activation patterns of microglia and their identification in the human brain
36/100 ✓ Peer-reviewed Inflammation and the immune system Neuropathology and applied neurobiology
Key finding: Some authors have suggested that these might be an overlapping continuum of functions rather than discrete categories.
Full summary, score breakdown and related studies → Original source
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2013-02-01
Wnt/β-catenin signalling: from plasma membrane to nucleus
36/100 ✓ Peer-reviewed Genetics The Biochemical journal
Key finding: Owing to the importance of Wnt signalling in a wide range of biological fields, a better understanding of its precise mechanisms could provide fundamental insights for therapeutic applications. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-02-01
Educating families about end-of-life care in advanced dementia: acceptability of a Canadian family booklet to nurses from Canada, France, and Japan
36/100 ✓ Peer-reviewed End-of-life care International journal of palliative nursing
Key finding: The booklet may help nurses educate families about end-of-life issues in dementia palliative care, but local adaptation of the booklet content and physician engagement are necessary.
Full summary, score breakdown and related studies → Original source
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2013-02-01
Mediterranean diet, healthy eating index 2005, and cognitive function in middle-aged and older Puerto Rican adults
36/100 ✓ Peer-reviewed Prevention trials Journal of the Academy of Nutrition and Dietetics
Key finding: Greater adherence to the Mediterranean diet was associated with higher Mini Mental State Examination score (P trend=0.012) and lower likelihood (odds ratio=0.87 for each additional point; 95% CI 0.80 to 0.94; P<0.001) of cognitive impairment, after adjustment for confounders. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-02-01
The application of cerebrospinal fluid biomarkers in early diagnosis of Alzheimer disease
41/100 ✓ Peer-reviewed Tau biomarkers The Medical clinics of North America
Key finding: The clinically most relevant biomarkers, total tau, phospho-tau and Aβ42 are discussed, and how they may be used, together with other diagnostic investigations, to make a predementia diagnosis of AD. +1 more finding
Full summary, score breakdown and related studies → Original source
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