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52/100

✓ Peer-reviewed alzhub usefulness score 52 out of 100. Biomarkers

Topic: Genetics and APOE

The study population consisted of 194 patients (123 AD and 71 non-AD). AD patients have significantly lower Aβ42 levels and Aβ42/40 ratio and higher pTau, tTau, and NfLs levels than non-AD patients. In AD patients, the APOEε4 allele is associated with a significantly lower Aβ42/40 ratio and higher levels of pTau, tTau, neurogranin, and alpha-synuclein. This association is not observed in non-AD patients. This study provides evidence of the significant impact of the APOE ε4 allele on neurodegenerative biomarkers in AD patients, highlighting its role in exacerbating amyloid and tau pathology as well as synaptic degeneration.

Key findings

The study population consisted of 194 patients (123 AD and 71 non-AD).
AD patients have significantly lower Aβ42 levels and Aβ42/40 ratio and higher pTau, tTau, and NfLs levels than non-AD patients.
In AD patients, the APOEε4 allele is associated with a significantly lower Aβ42/40 ratio and higher levels of pTau, tTau, neurogranin, and alpha-synuclein.
This association is not observed in non-AD patients.
This study provides evidence of the significant impact of the APOE ε4 allele on neurodegenerative biomarkers in AD patients, highlighting its role in exacerbating amyloid and tau pathology as well as synaptic degeneration.

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Study details

Participants194
Evidence strengthLow

How this study scored 52/100

Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 29 of the 56 points we could judge it on, which is 52 out of 100.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Clinica chimica acta; international journal of clinical chemistry)
Journal's citation record	— / 4	No journal record from OpenAlex — left out of this score
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2024 — within 3 year(s) of the newest study here
Sample size	2 / 4	194 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	— / 7	No citation count (not found in OpenAlex) — left out of this score
Citations per year	— / 5	No citation count or no year — left out of this score
Impact for its field and year	— / 6	No field-weighted citation impact (OpenAlex has none yet) — left out of this score
Cited by studies here	— / 6	Not yet checked against this library's citation graph — left out of this score
Still being cited	— / 4	No yearly citation counts — left out of this score
Senior author's track record	— / 4	Senior author's record not available — left out of this score
Institution's track record	— / 3	No institution listed in OpenAlex — left out of this score
Multi-centre collaboration	— / 3	Institutions not listed — left out of this score
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 39025198)
Free to read	— / 2	Access not recorded — left out of this score
Points	29 / 56	Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 29 of the 56 points we could judge it on is 52 out of 100.
Total	52 / 100	—

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Cite this study APA, Vancouver, BibTeX · download .bib or .ris

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APA 7th

Agnello, L., Gambino, C. M., Ciaccio, A. M., Piccoli, T., Blandino, V., Scazzone, C., et al. (2024). Exploring the effect of APOE ε4 on biomarkers of neurodegeneration in Alzheimer's disease. Clinica chimica acta; international journal of clinical chemistry. https://doi.org/10.1016/j.cca.2024.119876

Vancouver

Agnello L, Gambino CM, Ciaccio AM, Piccoli T, Blandino V, Scazzone C, et al. Exploring the effect of APOE ε4 on biomarkers of neurodegeneration in Alzheimer's disease. Clinica chimica acta; international journal of clinical chemistry. 2024. doi:10.1016/j.cca.2024.119876. PMID: 39025198.

BibTeX

@article{agnello2024-39025198,
  author  = {Agnello, Luisa and Gambino, Caterina Maria and Ciaccio, Anna Maria and Piccoli, Tommaso and Blandino, Valeria and Scazzone, Concetta and Sasso, Bruna Lo and Del Ben, Fabio and others},
  title   = {{Exploring the effect of APOE ε4 on biomarkers of neurodegeneration in Alzheimer's disease}},
  journal = {Clinica chimica acta; international journal of clinical chemistry},
  year    = {2024},
  doi     = {10.1016/j.cca.2024.119876},
  pmid    = {39025198},
  url     = {https://doi.org/10.1016/j.cca.2024.119876}
}

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