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PM2.5 triggers tau aggregation in a mouse model of tauopathy
Congcong Liu, Lanxia Meng, Yan Gao, Jiehui Chen, Min Zhu, Min Xiong, Tingting Xiao, Xiaoling Gu et al.. JCI insight, 2024-07-22
Topic: Air pollution and environmental exposures
The aggregation and prion-like propagation of tau are the hallmarks of Alzheimer's disease (AD) and other tauopathies. However, the molecular mechanisms underlying the assembly and spread of tau pathology remain elusive. Epidemiological data show that exposure to fine particulate matter (PM2.5) is associated with an increased risk of AD. However, the molecular mechanisms remain unknown. Here, we showed that PM2.5 triggered the aggregation of tau and promoted the formation of tau fibrils. Injection of PM2.5-induced tau preformed fibrils (PFFs) into the hippocampus of tau P301S transgenic mice promoted the aggregation of tau and induced cognitive deficits and synaptic dysfunction. Furthermore, intranasal administration of PM2.5 exacerbated tau pathology and induced cognitive impairment in tau P301S mice. In conclusion, our results indicated that PM2.5 exposure promoted tau pathology and induced cognitive impairments. These results provide mechanistic insight into how PM2.5 increases the risk of AD.
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APA 7th
Liu, C., Meng, L., Gao, Y., Chen, J., Zhu, M., Xiong, M., et al. (2024). PM2.5 triggers tau aggregation in a mouse model of tauopathy. JCI insight. https://doi.org/10.1172/jci.insight.176703
Vancouver
Liu C, Meng L, Gao Y, Chen J, Zhu M, Xiong M, et al. PM2.5 triggers tau aggregation in a mouse model of tauopathy. JCI insight. 2024. doi:10.1172/jci.insight.176703. PMID: 39133647.
BibTeX
@article{liu2024-39133647,
author = {Liu, Congcong and Meng, Lanxia and Gao, Yan and Chen, Jiehui and Zhu, Min and Xiong, Min and Xiao, Tingting and Gu, Xiaoling and others},
title = {{PM2.5 triggers tau aggregation in a mouse model of tauopathy}},
journal = {JCI insight},
year = {2024},
doi = {10.1172/jci.insight.176703},
pmid = {39133647},
url = {https://doi.org/10.1172/jci.insight.176703}
}
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Key findings
- Epidemiological data show that exposure to fine particulate matter (PM2.5) is associated with an increased risk of AD.
- Here, we showed that PM2.5 triggered the aggregation of tau and promoted the formation of tau fibrils.
- In conclusion, our results indicated that PM2.5 exposure promoted tau pathology and induced cognitive impairments.
- These results provide mechanistic insight into how PM2.5 increases the risk of AD.
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Study details
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 24 of the 56 points we could judge it on, which is 43 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (JCI insight) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Laboratory or animal study (title names “mouse”) — scores zero |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39133647) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 24 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 24 of the 56 points we could judge it on is 43 out of 100. |
| Total | 43 / 100 | — |
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