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Ambient air pollution, covert cerebrovascular disease and cognition: results from the ISSYS study
A Ballvé, J Pizarro, O Maisterra, I Riba-Llena, F Pujadas, J Jiménez-Balado, A Palasi, M Cirach et al.. European journal of neurology, 2024-07-19
Topic: Air pollution and environmental exposures
At baseline, 99 participants (10.1%) had covert brain infarcts and 91 (9.3%) had extensive periventricular white matter hyperintensities (WMHs). Marked subcortical WMH progression was seen in 19.7%; the incidence of other covert cerebrovascular lessons ranged between 5% and 6% each. PM2.5 was related to higher odds of having a covert brain infarct (odds ratio [OR] 2.21; 95% confidence interval [CI] 1.06-4.60). PM2.5 absorbance was related to higher odds of having extensive subcortical WMHs (OR 1.72; 95% CI 1.13-2.60), whereas NO2 was related to higher odds of having extensive subcortical (OR 1.66; 95% CI 1.17-2.35) or periventricular (OR 1.96; 95% CI 1.10-3.50) WMHs and to higher odds of developing marked subcortical WMH progression (OR 1.40; 95% CI 1.05-1.90). NOx was related to incident cerebral microbleeds (OR 1.36; 95% CI 1.04-1.79). There was no association between AP and cognition. Air pollutant predicts the presence and accumulation of cCVD. Its impact on cognitive impairment remains to be determined.
Key findings
- At baseline, 99 participants (10.1%) had covert brain infarcts and 91 (9.3%) had extensive periventricular white matter hyperintensities (WMHs).
- Marked subcortical WMH progression was seen in 19.7%; the incidence of other covert cerebrovascular lessons ranged between 5% and 6% each.
- PM2.5 was related to higher odds of having a covert brain infarct (odds ratio [OR] 2.21; 95% confidence interval [CI] 1.06-4.60).
- PM2.5 absorbance was related to higher odds of having extensive subcortical WMHs (OR 1.72; 95% CI 1.13-2.60), whereas NO2 was related to higher odds of having extensive subcortical (OR 1.66; 95% CI 1.17-2.35) or periventricular (OR 1.96; 95% CI 1.10-3.50) WMHs and to higher odds of developing marked subcortical WMH progression (OR 1.40; 95% CI 1.05-1.90).
- NOx was related to incident cerebral microbleeds (OR 1.36; 95% CI 1.04-1.79).
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Study details
- Participants976
- Effect size10.1%; 9.3%; 19.7%
- Evidence strengthLow
How this study scored 55/100
Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 31 of the 56 points we could judge it on, which is 55 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (European journal of neurology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 976 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39031977) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 31 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 31 of the 56 points we could judge it on is 55 out of 100. |
| Total | 55 / 100 | — |
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APA 7th
Ballvé, A., Pizarro, J., Maisterra, O., Riba-Llena, I., Pujadas, F., Jiménez-Balado, J., et al. (2024). Ambient air pollution, covert cerebrovascular disease and cognition: results from the ISSYS study. European journal of neurology. https://doi.org/10.1111/ene.16404
Vancouver
Ballvé A, Pizarro J, Maisterra O, Riba-Llena I, Pujadas F, Jiménez-Balado J, et al. Ambient air pollution, covert cerebrovascular disease and cognition: results from the ISSYS study. European journal of neurology. 2024. doi:10.1111/ene.16404. PMID: 39031977.
BibTeX
@article{ballve2024-39031977,
author = {Ballvé, A and Pizarro, J and Maisterra, O and Riba-Llena, I and Pujadas, F and Jiménez-Balado, J and Palasi, A and Cirach, M and others},
title = {{Ambient air pollution, covert cerebrovascular disease and cognition: results from the ISSYS study}},
journal = {European journal of neurology},
year = {2024},
doi = {10.1111/ene.16404},
pmid = {39031977},
url = {https://doi.org/10.1111/ene.16404}
}