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The striatum is an early, accurate indicator of amyloid burden using [11C]PiB in Down syndrome: comparison of two radiotracers
McLachlan M, Bettcher B, McVea A, DiFillipo A, Zammit M, LeMerise L, Rouanet J, Price J et al.. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024-12-06
Topic: Brain proteins, microglia and lab models
INTRODUCTION Adults with Down syndrome demonstrate striatum-first amyloid accumulation with [ 11 C]PiB PET imaging, which has not been replicated with [ 18 F]florbetapir (FBP). Early striatal accumulation has not been temporally quantified with respect to global cortical measures. METHODS Longitudinal PiB (n=175 participants) and FBP (n=92 participants) data from the Alzheimer Biomarkers Consortium-Down Syndrome were used to measure cortical and striatal binding.
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APA 7th
McLachlan, M., Bettcher, B., McVea, A., DiFillipo, A., Zammit, M., LeMerise, L., et al. (2024). The striatum is an early, accurate indicator of amyloid burden using [11C]PiB in Down syndrome: comparison of two radiotracers. Alzheimer's & dementia : the journal of the Alzheimer's Association. https://doi.org/10.1101/2024.12.04.24318526
Vancouver
McLachlan M, Bettcher B, McVea A, DiFillipo A, Zammit M, LeMerise L, et al. The striatum is an early, accurate indicator of amyloid burden using [11C]PiB in Down syndrome: comparison of two radiotracers. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024. doi:10.1101/2024.12.04.24318526.
BibTeX
@article{mclachlan2024-c829b099,
author = {McLachlan, M. and Bettcher, B. and McVea, A. and DiFillipo, A. and Zammit, M. and LeMerise, L. and Rouanet, J. and Price, J. and others},
title = {{The striatum is an early, accurate indicator of amyloid burden using [11C]PiB in Down syndrome: comparison of two radiotracers}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2024},
doi = {10.1101/2024.12.04.24318526},
url = {https://doi.org/10.1101/2024.12.04.24318526}
}
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Key findings
- Early striatal accumulation has not been temporally quantified with respect to global cortical measures.
- METHODS Longitudinal PiB (n=175 participants) and FBP (n=92 participants) data from the Alzheimer Biomarkers Consortium-Down Syndrome were used to measure cortical and striatal binding.
- Generalized temporal models for cortical and striatal amyloid accumulation were created using the sampled iterative local approximation (SILA) method.
- RESULTS PiB demonstrated greater striatal-to-cortical ratios than FBP.
Why it matters
Using longitudinal PET data, this study found that the striatum shows early amyloid accumulation with PiB, and PiB showed greater striatal-to-cortical binding than florbetapir. It is an imaging biomarker study and reports no treatment, cure, or prevention.
Study details
- Study designlongitudinal study
- Participants175
- Evidence strengthModerate
How this study scored 63/100
Published in a leading specialty journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 40 of the 64 points we could judge it on, which is 63 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia : the journal of the Alzheimer's Association) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 175 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40189783) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 40 / 64 | Scored on 12 of 20 parts. We have no data for the rest, so they are left out: 40 of the 64 points we could judge it on is 63 out of 100. |
| Total | 63 / 100 | — |
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