Newest studies

Translational Research on Polygenic Risk Scores in Common Neurodegenerative Diseases - A Scoping Review Protocol

43/100 ✓ Peer-reviewed Genetics Acta medica academica

Key finding: The purpose of this protocol is to clearly describe the process for the scoping review we plan to conduct on the topic of polygenic risk scores (PRS) in common neurodegenerative diseases.

• Genetics

Full summary, score breakdown and related studies → Original source

Peripheral risk factors and their role in biomarker-based screening for dementia in the community

55/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Besides age and estimated glomerular filtration rate (eGFR), significant associations were found between plasma biomarkers and clusters related to hemoglobin, red blood cell distribution, and inflammation. +4 more findings

• Biomarkers
• Risk Factors

Full summary, score breakdown and related studies → Original source

Anti-amyloid treatments in Alzheimer's disease: elegance, evidence and ethics

41/100 ✓ Peer-reviewed Treatments Advances in clinical and experimental medicine : official organ Wroclaw Medical University

Key finding: In conclusion, we are critical of over-reliance on the idea that PET amyloid-lowering treatments for AD are a therapeutic revolution as claimed, and consider that optimism does not excuse a lack of scientific, regulatory, and ethical integrity.

• Treatments
• Side Effects
• Brain Scans

Full summary, score breakdown and related studies → Original source

Sensitivity and specificity of a seed amplification assay for diagnosis of multiple system atrophy: a multicentre cohort study

67/100 ✓ Peer-reviewed Disease mechanisms The Lancet. Neurology

Key finding: CSF-soluble misfolded α-synuclein aggregates (seeds) are readily detected in people with Parkinson's disease by α-synuclein seed amplification assay (synSAA), but identification of seeds associated with multiple system atrophy for diagnostic purposes has proven elusive. +1 more finding

• Diagnosis

Full summary, score breakdown and related studies → Original source

Greater neighborhood deprivation is related to shorter survival in behavioral‐variant frontotemporal degeneration

39/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Our results suggest that increased neighborhood deprivation contributes to shorter survival in bvFTD. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Neighborhood disadvantage is associated with altered cortical organization

36/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Our findings suggest differences in local cortical organization by neighborhood disadvantage, which also mediated the relationship between ADI and cognitive performance, providing a possible network‐based mechanism, explaining risk for cognitive decline and dementia associated with disadvantaged neighborhoods. +2 more findings

• Health Equity

Full summary, score breakdown and related studies → Original source

Neighborhood disadvantage is associated with altered cortical organization

36/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Our findings suggest differences in local cortical organization by neighborhood disadvantage, which also mediated the relationship between ADI and cognitive performance, providing a possible network‐based mechanism, explaining risk for cognitive decline and dementia associated with disadvantaged neighborhoods. +2 more findings

• Health Equity

Full summary, score breakdown and related studies → Original source

The Southern Illinois University Longitudinal Cognitive Aging Study: A Cohort Analysis

45/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: The study has enrolled over 1,600 normal control participants since study inception. 150 original participants continue their participation.

Full summary, score breakdown and related studies → Original source

Association between the social exposome and vascular brain injury in brain bank donors

31/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: This study shows promise for clarifying the relationship between the social exposome and ADRD brain pathology post‐mortem. +3 more findings

Full summary, score breakdown and related studies → Original source

MCI Diagnosis and Neighborhood Disadvantage Predict Differences in White Matter Microstructure in a Rural Aging Cohort

38/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: These preliminary findings reveal white matter alterations associated with consensus MCI diagnosis and to socioeconomic differences in a clinical cohort of rural‐dwelling older adults. +4 more findings

• Health Equity
• Early Stage
• Diagnosis

Full summary, score breakdown and related studies → Original source

Characterizing Exposure to Traffic‐Related Air Pollution in a Diverse Alzheimer’s Disease Research Center Cohort

39/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Preliminary analysis indicates significant differences in location, ethnoracial background, ADI, and TRAP exposure amongst UCD ADRC participants. +4 more findings

• Risk Factors
• Health Equity

Full summary, score breakdown and related studies → Original source

MCI Diagnosis and Neighborhood Disadvantage Predict Differences in White Matter Microstructure in a Rural Aging Cohort

36/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: These preliminary findings reveal white matter alterations associated with consensus MCI diagnosis and to socioeconomic differences in a clinical cohort of rural‐dwelling older adults. +4 more findings

• Health Equity
• Early Stage
• Diagnosis

Full summary, score breakdown and related studies → Original source

Exploring Neighborhood Level Socioeconomic Status and Volumetric MRI Results in Patients with Memory Impairment

38/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Contrary to expectations, high versus low ADI groups only showed a difference in hippocampal volume, but in the reverse direction. +3 more findings

• Brain Scans
• Health Equity

Full summary, score breakdown and related studies → Original source

The Impact of Neighborhood‐Level Area Deprivation on Picture Naming Ability and Decline in Alzheimer’s Disease

30/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Our study unveils the complex interplay between area deprivation and language decline in AD patients. +4 more findings

Full summary, score breakdown and related studies → Original source

Relationship Between Social Support and Global Cognition by Level of Neighborhood Disadvantage in the HABS‐HD Cohort

41/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Overall, these findings highlight the generally robust, protective effect of social support on cognitive abilities in this large, diverse cohort of older adults. +4 more findings

• Health Equity

Full summary, score breakdown and related studies → Original source

The relationship between neighborhood disadvantage and the brain age gap

49/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: This analysis found that the mean brain age gap does not significantly differ between Quintile 5 and Quintiles 1‐4 (p≤0.45), however statistical power was low given very broad confidence intervals. +2 more findings

• Risk Factors
• Health Equity

Full summary, score breakdown and related studies → Original source

Comparison of plasma p‐tau217 and Aβ42/Aβ40 biomarkers by race to detect Alzheimer’s disease

38/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: P‐tau217/Aβ42 had the highest performance to discriminate Aβ+ from Aβ‐ (Table 1A,1B; all AUC≥0.90), and p‐tau217 showed excellent accuracy in ADNI sample (0.96; Table 1B). +1 more finding

Full summary, score breakdown and related studies → Original source

Mayo Normative Studies: regression‐based normative data for remote self‐administration of the Stricker Learning Span, Symbols Test and Mayo Test Drive Screening Battery Composite for ages 33‐100 and validation in MCI and dementia

42/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Typical normative models appear appropriate for remote self‐administered measures and are sensitive to cognitive impairment. +2 more findings

• Early Stage
• Diagnosis

Full summary, score breakdown and related studies → Original source

Mayo Normative Studies: regression‐based normative data for remote self‐administration of the Stricker Learning Span, Symbols Test and Mayo Test Drive Screening Battery Composite for ages 33‐100 and validation in MCI and dementia

50/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Typical normative models appear appropriate for remote self‐administered measures and are sensitive to cognitive impairment. +2 more findings

• Early Stage
• Diagnosis

Full summary, score breakdown and related studies → Original source

Trends in Incidence and Prevalence of Dementia Among United States Medicare Beneficiaries, 2014‐2021, by Race, Sex, and Neighborhood Socioeconomic Status

41/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: We found declining dementia incidence but increasing dementia prevalence in a sample that includes the vast majority of older adults in the United States. +2 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Trends in Diagnosis of Dementia Subtypes in Nationwide Medicare Claims, 2015‐2021, by Race/Ethnicity, Sex, and Neighborhood Socioeconomic Status

38/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: In a national database of Medicare claims, there were substantial secular trends and differences in coding of dementia subtypes by race/ethnicity, sex, and neighborhood socioeconomic status. +1 more finding

• Health Equity
• Risk Factors
• Diagnosis

Full summary, score breakdown and related studies → Original source

Mapping healthcare utilization of people with Alzheimer’s Disease and Related Dementias to identify priority areas in the State of South Carolina

37/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: The findings from this study provide clear evidence that there is a greater need for resources to support SC residents with ADRD and their caregivers in the Pee Dee and Upstate regions.

Full summary, score breakdown and related studies → Original source

Associations between Social Determinants of Health and Alzheimer’s Disease and Related Dementia among American Indian and Alaska Native and White Medicare Beneficiaries

34/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: SDOH are potentially modifiable factors, therefore, a deeper understanding of their effects on ADRD can inform future interventions aimed at reducing ADRD prevalence and disparities. +4 more findings

• Health Equity
• Policy

Full summary, score breakdown and related studies → Original source

NEIGHBORHOOD DISADVANTAGE AND THE ASSOCIATION OF PLASMA BIOMARKERS WITH COGNITION IN A COHORT OF DIVERSE ADULTS

38/100 ✓ Peer-reviewed Risk factors Innovation in Aging

Key finding: We found ADI*pTau217 interactions on immediate and delayed word recall. +4 more findings

• Biomarkers
• Health Equity

Full summary, score breakdown and related studies → Original source

Broadband access may influence variation in Alzheimer’s disease and related dementias prevalence in Central Appalachia

29/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Among all Central Appalachian counties, 52%‐97% had broadband access throughout the study period (Figures 1‐2).

Full summary, score breakdown and related studies → Original source