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53/100

✓ Peer-reviewed alzhub usefulness score 53 out of 100. Vascular contributions

Topic: Brain proteins, microglia and lab models

Cohort 1 included 446 individuals (mean age (SD) 65.2 years (8.9); 203 women), Cohort 2 included 164 individuals (mean age (SD) 49.9 years (12.6); 88 women). Baseline DTI-ALPS index was independently associated with better longitudinal processing speed (Cohort 1:β=0.11, 95 %CI 0.03-0.19) and cognitive index (Cohort 2:β=0.20, 95 %CI 0.06-0.33). Neither PVS burden, DTI-ALPS index nor PSMD were significantly associated with increased risk of all-cause dementia. These findings suggest that DTI-ALPS index may serve as a marker for cognitive decline. However, these markers have limited association with all-cause dementia risk. Future studies are needed to validate DTI-ALPS index and its link to cognitive decline.

Key findings

Cohort 1 included 446 individuals (mean age (SD) 65.2 years (8.9); 203 women), Cohort 2 included 164 individuals (mean age (SD) 49.9 years (12.6); 88 women).
Baseline DTI-ALPS index was independently associated with better longitudinal processing speed (Cohort 1:β=0.11, 95 %CI 0.03-0.19) and cognitive index (Cohort 2:β=0.20, 95 %CI 0.06-0.33).
Neither PVS burden, DTI-ALPS index nor PSMD were significantly associated with increased risk of all-cause dementia.
These findings suggest that DTI-ALPS index may serve as a marker for cognitive decline.
However, these markers have limited association with all-cause dementia risk.

Why it matters

A higher baseline DTI-ALPS index was linked to better processing speed and cognitive index over time, but perivascular space burden, DTI-ALPS index and PSMD were not linked to risk of all-cause dementia. These markers may help track cognitive decline but showed limited link to dementia risk, and no treatment was tested.

Study details

Study designlongitudinal study
Participants446
Evidence strengthModerate

How this study scored 53/100

Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 51 of the 96 points we could judge it on, which is 53 out of 100.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Cerebral Circulation - Cognition and Behavior)
Journal's citation record	0 / 4	Cerebral Circulation - Cognition and Behavior: journal h-index 19 (OpenAlex, 2026-10-29)
Study design	7 / 12	A longitudinal study following the same people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	2 / 4	446 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 4 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	1.3 citations a year over 3 year(s) since 2025
Impact for its field and year	2 / 6	Cited 2.3× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 4 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	— / 4	OpenAlex's profile for last-listed author Anil Man Tuladhar holds only 6 work(s), too few to judge a track record — left out of this score
Institution's track record	3 / 3	Centre National de la Recherche Scientifique: institution h-index 2,511 (OpenAlex)
Multi-centre collaboration	3 / 3	OpenAlex lists 16 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41216615)
Free to read	2 / 2	Free to read
Points	51 / 96	Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 51 of the 96 points we could judge it on is 53 out of 100.
Total	53 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

APA 7th

Guardia, G. S., Li, H., Lebenberg, J., Jacob, M. A., Uszynski, I., Kessels, R. P. C., et al. (2025). Perivascular spaces, diffusion MRI markers and cognitive decline in cerebral small vessel disease. Cerebral Circulation - Cognition and Behavior. https://doi.org/10.1016/j.cccb.2025.100405

Vancouver

Guardia GS, Li H, Lebenberg J, Jacob MA, Uszynski I, Kessels RPC, et al. Perivascular spaces, diffusion MRI markers and cognitive decline in cerebral small vessel disease. Cerebral Circulation - Cognition and Behavior. 2025. doi:10.1016/j.cccb.2025.100405. PMID: 41216615.

BibTeX

@article{guardia2025-41216615,
  author  = {Guardia, Gemma Sole and Li, Hao and Lebenberg, Jessica and Jacob, Mina Ayad and Uszynski, Ivy and Kessels, Roy P. C. and Norris, David Gordon and Poupon, Cyril and others},
  title   = {{Perivascular spaces, diffusion MRI markers and cognitive decline in cerebral small vessel disease}},
  journal = {Cerebral Circulation - Cognition and Behavior},
  year    = {2025},
  doi     = {10.1016/j.cccb.2025.100405},
  pmid    = {41216615},
  url     = {https://doi.org/10.1016/j.cccb.2025.100405}
}

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