Newest studies

The association of seizure control with neuropathology in dementia

52/100 ✓ Peer-reviewed Long-term cohort studies Brain

Key finding: Seizures in people with dementia (PWD) are associated with faster cognitive decline and worse clinical outcomes. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Assessment of Cognitive Functions in Multimorbid Patients in Lithuanian Primary Care Settings: A Cross-Sectional Study Using MMSE and LT-GPCOG

44/100 ✓ Peer-reviewed Cognitive tests and assessment Medicina

Key finding: Out of 796 participants, 793 completed the study. +4 more findings

• Diagnosis
• Care Services

Full summary, score breakdown and related studies → Original source

Avanços em biomarcadores plasmáticos e do líquido cefalorraquidiano para a detecção precoce da doença de Alzheimer

27/100 ✓ Peer-reviewed Tau biomarkers Brazilian Journal of Health Review

Key finding: A pesquisa destacou a importância de biomarcadores como p-tau e β-amiloide no diagnóstico precoce e acompanhamento da Doença de Alzheimer (DA). +4 more findings

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Modifiable risk factors for early- and late-onset dementia using the Korean national health insurance service database

42/100 ✓ Peer-reviewed Risk factors The Journal of Prevention of Alzheimer s Disease

Key finding: Higher socioeconomic status and increased frequency of physical activity were associated with a lower risk of both EOD and LOD. +4 more findings

• Risk Factors
• Prevention
• Lifestyle

Full summary, score breakdown and related studies → Original source

Cardiometabolic Multimorbidity and Dementia Onset Among Middle-Aged and Older Adults: Differences by Race/Ethnicity

53/100 ✓ Peer-reviewed Disparities The Journals of Gerontology Series A

Key finding: Over a mean follow-up of 14.6 years, 7.7% of the participants (n = 614) developed dementia. +4 more findings

• Health Equity
• Risk Factors

Full summary, score breakdown and related studies → Original source

An evaluation of a community dementia screening program in rural Kenya: DEM‐SKY

38/100 ✓ Peer-reviewed Disparities Alzheimer s & Dementia

Key finding: The program demonstrated good acceptability, adoption, and fidelity and was effective in instigating behavior change. +4 more findings

• Health Equity
• Diagnosis

Full summary, score breakdown and related studies → Original source

Service delivery and the role of clinical pharmacists in UK primary care for older people, including people with dementia: a scoping review

45/100 ✓ Peer-reviewed Caregiving BMC Family Practice

Key finding: These detail the multifaceted responsibilities of clinical pharmacists in primary care for older people. +4 more findings

• Care Services
• Health Equity

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Barriers and facilitators to implementing person-centred dementia care in long-term care facilities in Western and Asian countries: a scoping review

49/100 ✓ Peer-reviewed Caregiving Frontiers in Psychiatry

Key finding: Over half were conducted in Western countries (n =20). +4 more findings

• Care Services

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Neuraminidase 1 regulates neuropathogenesis by governing the cellular state of microglia via modulation of Trem2 sialylation

46/100 ✓ Peer-reviewed Tau biomarkers Cell reports

Key finding: As such, NEU1 regulates immune cells, primarily those of the monocytic lineage. +3 more findings

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Pathways to Racial/Ethnic Inequalities in Dementia

43/100 ✓ Peer-reviewed Disparities Annual review of clinical psychology

Key finding: This health inequality reflects structural racism, which creates and sustains racial differences in social determinants of health, including education access and quality, economic stability, social and community context, neighborhood and built environment, and health care access and quality. +4 more findings

• Health Equity

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Point of view: Challenges in implementation of new immunotherapies for Alzheimer's disease

46/100 ✓ Peer-reviewed Health systems and care delivery The journal of prevention of Alzheimer's disease

Key finding: The advancement of disease-modifying treatments (DMTs) for Alzheimer's disease (AD), along with the approval of three amyloid-targeting therapies in the US and several other countries, represents a significant development in the treatment landscape, offering new hope for addressing this once untreatable chronic progressive disease. +2 more findings

• Care Services
• Treatments
• Policy

Full summary, score breakdown and related studies → Original source

Neighborhood environment associations with cognitive function and structural brain measures in older African Americans

54/100 ✓ Peer-reviewed Risk factors BMC medicine

Key finding: Since older adults spend significant time in their neighborhood environment, environmental factors such as neighborhood socioeconomic disadvantage, high racial segregation, low healthy food availability, low access to recreation, and minimal social engagement may have adverse effects on cognitive function and increase susceptibility to dementia. +4 more findings

• Health Equity

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Low-dose intranasal deferoxamine modulates memory, neuroinflammation, and the neuronal transcriptome in the streptozotocin rodent model of Alzheimer’s disease

42/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in Neuroscience

Key finding: Five weeks of daily IN dosing of Long Evans rats with 15 μL of a 1% (0.3 mg), but not 0.1% (0.03 mg), solution of DFO rescued cognitive impairment caused by ICV STZ administration as assessed with the Morris Water Maze (MWM) test of spatial memory and learning. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis

44/100 ✓ Peer-reviewed Inflammation and the immune system Molecular Neurodegeneration

Key finding: Here, we found that the level of histone deacetylase 7 (HDAC7) was remarkably increased in the astrocytes of AD patients and P301S tau transgenic (PS19) mice. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Mitochondria-derived vesicles: New players in the game of neurodegeneration

32/100 ✓ Peer-reviewed Risk genes beyond APOE Neural Regeneration Research

Key finding: MDVs are small vesicles that bud from mitochondria and play an important role in removing damaged mitochondrial components. +4 more findings

• Brain Biology

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Neuropsychological and clinical indicators of Lewy body and Alzheimer's pathology

37/100 ✓ Peer-reviewed Lewy body dementia Journal of Alzheimer s Disease Reports

Key finding: Gait disturbances (odds ratio (OR) = 19.32; p = 0.01), visual-spatial complaints (OR = 6.06; p = 0.03), and visual hallucinations (OR = 31.06; p = 0.002) predicted DLB compared to AD, along with better memory (OR = 3.42; p = 0.003), naming (OR = 3.35; p = 0.002), and worse processing speed (OR = 0.51; p = 0.01). +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Longitudinal FDG-PET Metabolic Change Along the Lewy Body Continuum

61/100 ✓ Peer-reviewed Lewy body dementia JAMA Neurology

Key finding: Thirty-five patients with probable DLB, 37 patients with MCI-LB, and 100 individuals without cognitive impairment were included. +4 more findings

• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source

Preventing dementia in Italy: Estimations of modifiable risk factors and public health implications

51/100 ✓ Peer-reviewed Disparities The Journal of Prevention of Alzheimer s Disease

Key finding: The national combined PAF for 11 modifiable risk factors was 39.6 % (95 % CI: 20.8-55.9). +4 more findings

• Prevention
• Risk Factors

Full summary, score breakdown and related studies → Original source

Hereditary Breast Cancer: Comprehensive Risk Assessment and Prevention Strategies

39/100 ✓ Peer-reviewed Prevention and risk Genes

Key finding: Women carrying pathogenic/likely pathogenic (P/LP) variants in moderate- or high-penetrance genes have an increased risk of developing breast cancer. +1 more finding

• Prevention
• Genetics

Full summary, score breakdown and related studies → Original source

Antiamyloid Therapy and Cerebral Blood Flow Changes on MRI: A Potential Longitudinal Biomarker of Treatment Response?

44/100 ✓ Peer-reviewed Treatments American Journal of Neuroradiology

Key finding: Cases 4 and 6 have demonstrated no substantial changes in regional CBF thus far on therapy, with cognitive decline in Case 4.

• Treatments
• Brain Scans
• Biomarkers

Full summary, score breakdown and related studies → Original source

Cerebrospinal Fluid Biomarkers and Cognition in Alzheimer Disease and Frontotemporal Dementia in a Memory Clinic Setting

44/100 ✓ Peer-reviewed Tau biomarkers Alzheimer disease and associated disorders

Key finding: Currently available literature on the relationships between cerebrospinal fluid (CSF) biomarkers and cognitive performance in frontotemporal dementia (FTD) is very limited and inconclusive. +3 more findings

• Biomarkers
• Care Services
• Diagnosis

Full summary, score breakdown and related studies → Original source

Lifetime risk and projected burden of dementia

85/100 ✓ Peer-reviewed How common it is Nature Medicine

Key finding: These results highlight the urgent need for policies that enhance healthy aging, with a focus on health equity.

• Genetics

Full summary, score breakdown and related studies → Original source

The experience of “at‐risk” status for familial frontotemporal dementia (fFTD) and its impact on reproductive decision‐making: A qualitative study

41/100 ✓ Peer-reviewed Lewy body dementia Journal of Genetic Counseling

Key finding: Thirteen qualitative interviews were conducted with at-risk individuals, including parents and non-parents, and analyzed using Thematic Analysis to explore experiences of at-risk relatives of people with symptomatic FTD, attitudes toward reproductive decision-making, and, among parents, influences of genetic risk status on parenting. +4 more findings

• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

Digital Isolation and Dementia Risk in Older Adults: Longitudinal Cohort Study

54/100 ✓ Peer-reviewed How common it is Journal of Medical Internet Research

Key finding: The moderate to high isolation group demonstrated a significantly elevated risk of dementia compared with the low isolation group. +4 more findings

• Risk Factors
• Digital Tools

Full summary, score breakdown and related studies → Original source

Association Between Chewing Capacity and Mortality Risk: The Role of Diet and Ageing

55/100 ✓ Peer-reviewed Prevention and risk Journal Of Clinical Periodontology

Key finding: Participants with more FTUs were found to have a slower biological ageing process. +4 more findings

• Lifestyle
• Risk Factors

Full summary, score breakdown and related studies → Original source