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41/100

✓ Peer-reviewed alzhub usefulness score 41 out of 100. Vascular contributions

Topic: Brain proteins, microglia and lab models

• Anterior cingulate cortex (ACC) hypometabolism is a non-specific finding in many brain disorders. • ACC hypometabolism was more common in vascular cognitive impairment and dementia (VCID) than Alzheimer dementia (AD). • ACC hypometabolism correlated with cerebral small vessel disease markers. • ACC hypometabolism may be associated with motor stereotypies in VCID. • FDG-PET patterns of hypometabolism may identify vascular contributions to cognitive impairment The anterior cingulate cortex (ACC) is an important hub in the executive and salience networks. While fluorodeoxyglucose-positron emission tomography (FDG-PET) is valuable in dementia diagnosis, there is no FDG-PET imaging ‘signature’ in vascular cognitive impairment and dementia (VCID). We investigated whether ACC hypometabolism on FDG-PET brain imaging in people with VCID correlated with cerebral small vessel disease (CSVD), estimated via white matter hyperintensity (WMH) severity, and clinical features, comparing these results with an Alzheimer dementia (AD) cohort. We performed a retrospective clinical database review of patients seen at a specialist cognitive neurology service between 2009–2024 to identify patients with VCID and AD diagnoses. Demographic details, cognitive (Addenbrooke’s Cognitive Examination-Revised, ACE-R) and behavioural (Cambridge Behavioural Inventory, CBI) screens were collated where available. Two clinicians independently performed unblinded, visual assessments of clinical FDG-PET maps, rating for the presence or absence of ACC hypometabolism. WMH severity was estimated via Fazekas scale on clinical MRI as a measure of CSVD. 379 people were identified: 98 VCID (median (IQR) age: 71 (63–77)), and 281 AD (median (IQR) age 72 (66–79)). ACC hypometabolism was observed more frequently in people with VCID (74%) than AD (34%). ACC hypometabolism correlated with greater vascular risk factor burden and higher Fazekas scores. ACC hypometabolism correlated with WMH severity but was not specific to VCID. ACC hypometabolism on FDG-PET may represent a functional marker of vascular damage to frontal-subcortical circuits.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Thomas, S. T., Palanikumar, L., Darby, D., & Brodtmann, A. G. (2025). FDG-PET anterior cingulate cortex hypometabolism as a marker of cerebral small vessel disease in Alzheimer's and vascular cognitive impairment and dementia. Cerebral Circulation - Cognition and Behavior. https://doi.org/10.1016/j.cccb.2025.100404

Vancouver

Thomas ST, Palanikumar L, Darby D, Brodtmann AG. FDG-PET anterior cingulate cortex hypometabolism as a marker of cerebral small vessel disease in Alzheimer's and vascular cognitive impairment and dementia. Cerebral Circulation - Cognition and Behavior. 2025. doi:10.1016/j.cccb.2025.100404. PMID: 41210610.

BibTeX

@article{thomas2025-41210610,
  author  = {Thomas, Sarah T and Palanikumar, Logesh and Darby, David and Brodtmann, Amy G.},
  title   = {{FDG-PET anterior cingulate cortex hypometabolism as a marker of cerebral small vessel disease in Alzheimer's and vascular cognitive impairment and dementia}},
  journal = {Cerebral Circulation - Cognition and Behavior},
  year    = {2025},
  doi     = {10.1016/j.cccb.2025.100404},
  pmid    = {41210610},
  url     = {https://doi.org/10.1016/j.cccb.2025.100404}
}

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Key findings

• Anterior cingulate cortex (ACC) hypometabolism is a non-specific finding in many brain disorders. • ACC hypometabolism was more common in vascular cognitive impairment and dementia (VCID) than Alzheimer dementia (AD). • ACC hypometabolism correlated with cerebral small vessel disease markers. • ACC hypometabolism may be associated with motor stereotypies in VCID. • FDG-PET patterns of hypometabolism may identify vascular contributions to cognitive impairment The anterior cingulate cortex (ACC) is an important hub in the executive and salience networks.
We investigated whether ACC hypometabolism on FDG-PET brain imaging in people with VCID correlated with cerebral small vessel disease (CSVD), estimated via white matter hyperintensity (WMH) severity, and clinical features, comparing these results with an Alzheimer dementia (AD) cohort.

Why it matters

Reduced metabolism in the anterior cingulate cortex on FDG-PET was more common in vascular cognitive impairment and dementia than in Alzheimer's dementia and correlated with small vessel disease markers. This was a retrospective review and does not provide a treatment, cure, or prevention.

Study details

Participants379
Evidence strengthModerate

How this study scored 41/100

Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Cerebral Circulation - Cognition and Behavior)
Journal's citation record	0 / 4	Cerebral Circulation - Cognition and Behavior: journal h-index 19 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	2 / 4	379 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 2 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.7 citations a year over 3 year(s) since 2025
Impact for its field and year	2 / 6	Cited 1.3× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Amy G. Brodtmann: h-index 47 (OpenAlex, whole career)
Institution's track record	1 / 3	The University of Melbourne: institution h-index 1,342 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 4 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41210610)
Free to read	2 / 2	Free to read
Total	41 / 100	—

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