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Cerebral Small Vessel Disease: Current and Emerging Therapeutic Strategies
Yuewen Sun, Xiaoqian Song, C. J. Jin, Yilong Peng, Jing Zhou, Xueping Zheng. Aging and Disease, 2025-01-01
Topic: Risk, prevention and care in population studies
Cerebral small vessel disease (CSVD) is a common disease in older people, characterized by damage to intracranial microvessels, leading to cognitive decline, increased risk of stroke, and dementia. This review reviews the current therapeutic approaches for CSVD and the latest research advances, encompassing traditional pharmacological therapies, emerging targeted interventions grounded in pathophysiology, exploratory immune-related treatments, and advances in genetic research. In addition, the role of lifestyle modifications in disease management is discussed. The review emphasizes the importance of a holistic, personalized treatment strategy to improve outcomes. More clinical trials are needed to validate these treatments and optimize individualized treatment options for CSVD patients.
Key findings
- Cerebral small vessel disease (CSVD) is a common disease in older people, characterized by damage to intracranial microvessels, leading to cognitive decline, increased risk of stroke, and dementia.
Why it matters
This review covers current and emerging therapeutic strategies for cerebral small vessel disease, including pharmacological, immune-related, and genetic approaches, along with lifestyle modifications. It emphasizes that more clinical trials are needed to validate these treatments, so no therapy is established for treating, curing, or preventing Alzheimer's disease.
Study details
- Evidence strengthLow
How this study scored 36/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Aging and Disease) |
| Journal's citation record | 1 / 4 | Aging and Disease: journal h-index 107 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 10 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 3.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 3 / 6 | Cited 5.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 10 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Xueping Zheng: h-index 18 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Affiliated Hospital of Qingdao University: institution h-index 237 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39965248) |
| Free to read | 2 / 2 | Free to read |
| Total | 36 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Sun, Y., Song, X., Jin, C. J., Peng, Y., Zhou, J., & Zheng, X. (2025). Cerebral Small Vessel Disease: Current and Emerging Therapeutic Strategies. Aging and Disease. https://doi.org/10.14336/ad.2024.1515
Vancouver
Sun Y, Song X, Jin CJ, Peng Y, Zhou J, Zheng X. Cerebral Small Vessel Disease: Current and Emerging Therapeutic Strategies. Aging and Disease. 2025. doi:10.14336/ad.2024.1515. PMID: 39965248.
BibTeX
@article{sun2025-39965248,
author = {Sun, Yuewen and Song, Xiaoqian and Jin, C. J. and Peng, Yilong and Zhou, Jing and Zheng, Xueping},
title = {{Cerebral Small Vessel Disease: Current and Emerging Therapeutic Strategies}},
journal = {Aging and Disease},
year = {2025},
doi = {10.14336/ad.2024.1515},
pmid = {39965248},
url = {https://doi.org/10.14336/ad.2024.1515}
}
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