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42/100

✓ Peer-reviewed alzhub usefulness score 42 out of 100. Vascular contributions

Topic: Amyloid, tau and blood-test diagnosis

6.98 [2.44-19.95]; p < 0.05) driven primarily by self-identified Black race and age, while none with A and T. ASCVD risk score was also associated with WMHs ((β=0.42 ± 0.22; p = 0.05). In this asymptomatic, diverse cohort, 10-year ASCVD risk was predictive of late-life neurodegeneration and WMHs but not amyloid or tau. Further mechanistic studies can elucidate whether midlife ASCVD risk factors associated neurodegeneration initiates brain vulnerability leading to AD in late life.

Key findings

6.98 [2.44-19.95]; p < 0.05) driven primarily by self-identified Black race and age, while none with A and T.
ASCVD risk score was also associated with WMHs ((β=0.42 ± 0.22; p = 0.05).
In this asymptomatic, diverse cohort, 10-year ASCVD risk was predictive of late-life neurodegeneration and WMHs but not amyloid or tau.
Further mechanistic studies can elucidate whether midlife ASCVD risk factors associated neurodegeneration initiates brain vulnerability leading to AD in late life.

Why it matters

In an asymptomatic, diverse cohort, midlife cardiovascular risk score predicted later neurodegeneration and white matter hyperintensities but not amyloid or tau. The authors call for further studies to see whether midlife cardiovascular risk factors initiate brain vulnerability leading to Alzheimer's disease.

Study details

Effect size7.4%; 7.5%
Evidence strengthModerate

How this study scored 42/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of Alzheimer s Disease Reports)
Journal's citation record	0 / 4	Journal of Alzheimer s Disease Reports: journal h-index 40 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	2 / 7	Cited 5 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	1.7 citations a year over 3 year(s) since 2025
Impact for its field and year	3 / 6	Cited 3.2× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 5 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Ann D. Cohen: h-index 44 (OpenAlex, whole career)
Institution's track record	1 / 3	University of Pittsburgh: institution h-index 1,470 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 5 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40034508)
Free to read	2 / 2	Free to read
Total	42 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

APA 7th

Saeed, A., Chang, Y.-F., Swanson, J., Vu, M., Mapstone, M. E., Villemagne, V. L., et al. (2025). Association of mid-life cardiovascular risk with biomarkers of Alzheimer's disease, neurodegeneration, and white matter hyperintensities: Heart SCORE brain study. Journal of Alzheimer s Disease Reports. https://doi.org/10.1177/25424823241299297

Vancouver

Saeed A, Chang Y.-F, Swanson J, Vu M, Mapstone ME, Villemagne VL, et al. Association of mid-life cardiovascular risk with biomarkers of Alzheimer's disease, neurodegeneration, and white matter hyperintensities: Heart SCORE brain study. Journal of Alzheimer s Disease Reports. 2025. doi:10.1177/25424823241299297. PMID: 40034508.

BibTeX

@article{saeed2025-40034508,
  author  = {Saeed, Anum and Chang, Yue-Fang and Swanson, Justin and Vu, Michael and Mapstone, Mark E. and Villemagne, Victor L. and Snitz, Beth Ellen and Royse, Sarah K. and others},
  title   = {{Association of mid-life cardiovascular risk with biomarkers of Alzheimer's disease, neurodegeneration, and white matter hyperintensities: Heart SCORE brain study}},
  journal = {Journal of Alzheimer s Disease Reports},
  year    = {2025},
  doi     = {10.1177/25424823241299297},
  pmid    = {40034508},
  url     = {https://doi.org/10.1177/25424823241299297}
}

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