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Association Between Chewing Capacity and Mortality Risk: The Role of Diet and Ageing
Mi Du, Ke Deng, Jiawei Yin, Chenkai Wu, Shixian Hu, Linxu Guo, Zhixin Luo, Maurizio S. Tonetti et al.. Journal Of Clinical Periodontology, 2025-01-12
Topic: Risk, prevention and care in population studies
Participants with more FTUs were found to have a slower biological ageing process. Diet quality scores were estimated to mediate 9.0%-23.0% of the association between chewing capacity and biological ageing. Multivariable Cox proportional hazards regression models found a positive association between ICC and all-cause mortality (hazard ratio = 1.282 [95% confidence interval: 1.189-1.382]). Also, ICC was significantly associated with a 28.9% higher risk of mortality due to cardiovascular disease (CVD) and a 32.7% higher risk of mortality due to cancer. Mediation analyses indicated that PhenoAgeAccel mediated the effect of ICC on all-cause, CVD and cancer mortality with proportions of 18.1%, 17.3% and 12.5%, respectively. Similar mediating proportions were observed in the frailty index (range: 11.6%-23.5%). ICC was associated with poorer diet quality and accelerated ageing, resulting in higher mortality risk. Therefore, it is plausible that dietary interventions and oral rehabilitation would promote healthy longevity, although further investigations are needed.
Key findings
- Participants with more FTUs were found to have a slower biological ageing process.
- Diet quality scores were estimated to mediate 9.0%-23.0% of the association between chewing capacity and biological ageing.
- Multivariable Cox proportional hazards regression models found a positive association between ICC and all-cause mortality (hazard ratio = 1.282 [95% confidence interval: 1.189-1.382]).
- Also, ICC was significantly associated with a 28.9% higher risk of mortality due to cardiovascular disease (CVD) and a 32.7% higher risk of mortality due to cancer.
- Mediation analyses indicated that PhenoAgeAccel mediated the effect of ICC on all-cause, CVD and cancer mortality with proportions of 18.1%, 17.3% and 12.5%, respectively.
Why it matters
This study is about chewing capacity, diet, ageing and mortality risk and contains no information on Alzheimer's disease. It reports no findings relevant to treating, curing or preventing dementia.
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Study details
- Participants22,900
- Effect size9.0%; 23.0%; 28.9%
- Evidence strengthLow
How this study scored 55/100
Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 53 of the 96 points we could judge it on, which is 55 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal Of Clinical Periodontology) |
| Journal's citation record | 3 / 4 | Journal Of Clinical Periodontology: journal h-index 267 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 4 / 4 | 22,900 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 3 / 7 | Cited 20 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 6.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 4 / 6 | Cited 16.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 2 / 4 | Cited 20 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | 1 / 3 | University of Groningen: institution h-index 1,383 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 12 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39800933) |
| Free to read | 2 / 2 | Free to read |
| Points | 53 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 53 of the 96 points we could judge it on is 55 out of 100. |
| Total | 55 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1111/jcpe.14122
- PubMed: 39800933
- Original source →
- Free full text: Journal Of Clinical Periodontology →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Du, M., Deng, K., Yin, J., Wu, C., Hu, S., Guo, L., et al. (2025). Association Between Chewing Capacity and Mortality Risk: The Role of Diet and Ageing. Journal Of Clinical Periodontology. https://doi.org/10.1111/jcpe.14122
Vancouver
Du M, Deng K, Yin J, Wu C, Hu S, Guo L, et al. Association Between Chewing Capacity and Mortality Risk: The Role of Diet and Ageing. Journal Of Clinical Periodontology. 2025. doi:10.1111/jcpe.14122. PMID: 39800933.
BibTeX
@article{du2025-39800933,
author = {Du, Mi and Deng, Ke and Yin, Jiawei and Wu, Chenkai and Hu, Shixian and Guo, Linxu and Luo, Zhixin and Tonetti, Maurizio S. and others},
title = {{Association Between Chewing Capacity and Mortality Risk: The Role of Diet and Ageing}},
journal = {Journal Of Clinical Periodontology},
year = {2025},
doi = {10.1111/jcpe.14122},
pmid = {39800933},
url = {https://doi.org/10.1111/jcpe.14122}
}
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