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61/100

✓ Peer-reviewed alzhub usefulness score 61 out of 100. Lewy body dementia

Topic: Brain proteins, microglia and lab models

Thirty-five patients with probable DLB, 37 patients with MCI-LB, and 100 individuals without cognitive impairment were included. The mean (SD) age of the DLB and MCI-LB groups combined (n = 72) was 69.6 (8.2) years; 66 patients (92%) were men and 6 (8%) were women. At follow-up, 18 participants (49%) with MCI-LB had progressed to probable DLB. Patients with MCI-LB had a faster decline in FDG-SUVr, compared with that of participants without cognitive impairment, in the posterior cingulate, occipital, parietal, temporal, and lateral frontal cortices. The same regions showed greater metabolic decline in patients with DLB than in participants without cognitive impairment, with the addition of anterior-middle cingulate, insula, and medial frontal orbital cortices. Rates of change in FDG-PET in these brain regions were combined into a region of interest (ROI) labeled longitudinal FDG-PET LB meta-ROI. The rate of change in FDG-SUVr in the meta-ROI correlated with the rate of change in CDR-SB, and sample size estimates were reported for potential clinical trials in DLB. Findings were confirmed in the subsample with neuropathologic confirmation (n = 20). Conclusions and Relevance: This study found that brain hypometabolism begins to evolve during the prodromal stages of DLB with changes paralleling symptomatic progression. These data may inform clinical practice and trials planning to use FDG-PET for biologic staging, monitoring disease progression, and potentially assessing treatment response.

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APA 7th

Ferreira, D., Przybelski, S. A., Lesnick, T. G., Diaz‐Galvan, P., Schwarz, C. G., Murray, M. M., et al. (2025). Longitudinal FDG-PET Metabolic Change Along the Lewy Body Continuum. JAMA Neurology. https://doi.org/10.1001/jamaneurol.2024.4643

Vancouver

Ferreira D, Przybelski SA, Lesnick TG, Diaz‐Galvan P, Schwarz CG, Murray MM, et al. Longitudinal FDG-PET Metabolic Change Along the Lewy Body Continuum. JAMA Neurology. 2025. doi:10.1001/jamaneurol.2024.4643. PMID: 39804619.

BibTeX

@article{ferreira2025-39804619,
  author  = {Ferreira, Daniel and Przybelski, Scott A. and Lesnick, Timothy G. and Diaz‐Galvan, Patricia and Schwarz, Christopher G. and Murray, Melissa M. and Dickson, Dennis W. and Nguyen, Aivi T. and others},
  title   = {{Longitudinal FDG-PET Metabolic Change Along the Lewy Body Continuum}},
  journal = {JAMA Neurology},
  year    = {2025},
  doi     = {10.1001/jamaneurol.2024.4643},
  pmid    = {39804619},
  url     = {https://doi.org/10.1001/jamaneurol.2024.4643}
}

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Key findings

Thirty-five patients with probable DLB, 37 patients with MCI-LB, and 100 individuals without cognitive impairment were included.
The mean (SD) age of the DLB and MCI-LB groups combined (n = 72) was 69.6 (8.2) years; 66 patients (92%) were men and 6 (8%) were women.
At follow-up, 18 participants (49%) with MCI-LB had progressed to probable DLB.
Patients with MCI-LB had a faster decline in FDG-SUVr, compared with that of participants without cognitive impairment, in the posterior cingulate, occipital, parietal, temporal, and lateral frontal cortices.
The same regions showed greater metabolic decline in patients with DLB than in participants without cognitive impairment, with the addition of anterior-middle cingulate, insula, and medial frontal orbital cortices.

Why it matters

Brain hypometabolism begins to evolve during the prodromal stages of dementia with Lewy bodies, with changes paralleling symptomatic progression. These data may inform clinical practice and trials planning, based on a case-control study of 72 patients with DLB or MCI-LB and 100 individuals without cognitive impairment.

Study details

Study designcase-control study
Participants72
Evidence strengthModerate

How this study scored 61/100

Published in a leading specialty journal, and it is a case-control study. Scored zero for effect reported and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (JAMA Neurology)
Journal's citation record	2 / 4	JAMA Neurology: journal h-index 235 (OpenAlex, 2026-10-29)
Study design	6 / 12	A case-control study
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	1 / 4	72 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	3 / 7	Cited 15 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	5.0 citations a year over 3 year(s) since 2025
Impact for its field and year	4 / 6	Cited 9.5× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	2 / 4	Cited 15 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Kejal Kantarci: h-index 103 (OpenAlex, whole career)
Institution's track record	2 / 3	Mayo Clinic: institution h-index 1,606 (OpenAlex)
Multicenter collaboration	2 / 3	OpenAlex lists 4 institution(s) in 3 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 39804619)
Free to read	2 / 2	Free to read
Total	61 / 100	—

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