Newest studies

Associations Between Changes in Levels of Phosphorylated Tau and Severity of Cognitive Impairment in Early Alzheimer Disease

70/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: In DDI (n = 431), participants were classified as CN A-/T- (n = 169), A+/T- (CN = 26, MCI = 24), A+/T+ (CN = 40, MCI = 105), and A-/T+ (CN = 34, MCI = 33), with a mean age of 64.1 years and 55.9% female. +1 more finding

• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source

Modifiable risk factors for stroke, dementia and late-life depression: a systematic review and DALY-weighted risk factors for a composite outcome

71/100 ✓ Peer-reviewed Risk factors Journal of neurology, neurosurgery, and psychiatry

Key finding: Our search yielded 182 meta-analyses meeting the inclusion criteria, of which 59 were selected to calculate DALY-weighted risk factors for a composite outcome. +4 more findings

• Risk Factors
• Prevention
• Lifestyle

Full summary, score breakdown and related studies → Original source

Plasma neurofilament light chain mediates the effect of subsyndromal symptomatic depression on cognitive decline in older adults

46/100 ✓ Peer-reviewed Biomarkers Frontiers in aging neuroscience

Key finding: Participants with SSD exhibited a greater increase in plasma NfL levels and more pronounced declines in global cognition, memory, executive function, language, and processing speed over 2 years compared to non-SSD participants. +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Using scores from the 4AT delirium detection tool as an indicator of possible dementia: a study of 75 221 older adult hospital admissions

46/100 ✓ Peer-reviewed Clinical safety Age and Ageing

Key finding: Of 75 221 admissions, 62 188 (82.7%; 33 625 unique patients; mean age 80.2 years; 55.8% female) had a 4AT on admission. +3 more findings

Full summary, score breakdown and related studies → Original source

Targeting brain health in subjective cognitive decline: insights from a multidomain randomized controlled trial

42/100 ✓ Peer-reviewed Prevention trials Aging Clinical and Experimental Research

Key finding: The MI group significantly improved in attention-executive functioning (p = 0.003) compared to ACI (Cohen's d: 0.47, 95% CI 0.13-0.79). +4 more findings

• Clinical Trials

Full summary, score breakdown and related studies → Original source

Mechanical stimulation prevents impairment of axon growth and overcompensates microtubule destabilization in cellular models of Alzheimer’s disease and related Tau pathologies

34/100 ✓ Peer-reviewed Disease mechanisms Frontiers in Medicine

Key finding: We recently demonstrated that low mechanical forces promote MT stabilization, which in turn promotes axon growth and neuronal maturation. +1 more finding

• Brain Biology
• Prevention

Full summary, score breakdown and related studies → Original source

Promotion of neuroinflammation in select hippocampal regions in a mouse model of perimenopausal Alzheimer’s disease

35/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in Molecular Biosciences

Key finding: Our results show that genotype, AOF, and sex contributed to AD-like pathology. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Improved dementia screening for elderly with low education in South Korea using the Cognitive Impairment Screening Test (CIST)

43/100 ✓ Peer-reviewed Cognitive tests and assessment Frontiers in Neuroscience

Key finding: When distinguishing NC from MCI/DM, the CIST outperformed the K-MMSE, demonstrating a higher AUC (0.869 vs. 0.842) and F1-score (0.697 vs. 0.409). +2 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Application of Upper Limb Multimodal Tasks Combined With fNIRS Technology in the Assessment of Mild Cognitive Impairment

33/100 ✓ Peer-reviewed Mild cognitive impairment Journal of Biophotonics

Key finding: Mild cognitive impairment (MCI) is primarily characterized by a gradual decline in cognitive function, where early detection and intervention are crucial to preventing Alzheimer's disease progression. +2 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Machine Learning for Predicting Postoperative Functional Disability and Mortality Among Older Patients With Cancer: Retrospective Cohort Study

53/100 ✓ Peer-reviewed Digital health tools JMIR Aging

Key finding: This study included 33,355 patients in the training, 14,294 in the internal validation, and 6711 in the external validation sets. +4 more findings

• Digital Tools

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Understanding barriers and optimizing socio‐cognitive assessment in the diagnosis of neurocognitive disorders

44/100 ✓ Peer-reviewed Getting a diagnosis Journal of Neuropsychology

Key finding: Seventy-eight (78) % of respondents reported no/limited experience with socio-cognitive measures; more than 85% agreed on their relevance in clinics. +4 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Mouse models of Anti-Aβ immunotherapies

45/100 ✓ Peer-reviewed Treatments Molecular neurodegeneration

Key finding: This review considers the use of these mouse models in understanding the mechanisms of Aβ clearance, cerebral amyloid angiopathy (CAA), blood brain barrier breakdown, neuroinflammation, and neuronal dysfunction in response to Aβ immunotherapy.

• Brain Biology
• Treatments

Full summary, score breakdown and related studies → Original source

Patients With Moderate to Severe Dementia Who Undergo Elective TKA Face Elevated Risks of Death, Delirium, and Intensive Interventions: A Large, Propensity-weighted Database Study

54/100 ✓ Peer-reviewed Clinical safety Clinical Orthopaedics and Related Research

Key finding: After adjusting for potentially confounding variables such as age, gender, and comorbidities, we found that individuals with mild dementia (HR 1.74 [95% confidence interval (CI) 1.12 to 2.70]; p = 0.01) and moderate to severe dementia (HR 3.05 [95% CI 1.80 to 5.17]; p < 0.001) both demonstrated elevated hazards of death compared with patients without dementia. +4 more findings

Full summary, score breakdown and related studies → Original source

The cost effectiveness of a multidomain intervention on physical, cognitive, vascular, dietary and psychosocial outcomes among community dwelling older adults with cognitive frailty in Malaysia: The AGELESS Trial

68/100 ✓ Peer-reviewed Prevention trials Alzheimer s Research & Therapy

Key finding: The trial occurred during the COVID-19 pandemic. +4 more findings

• Clinical Trials
• Policy
• Prevention

Full summary, score breakdown and related studies → Original source

The Role of Tau in Neuronal Function and Neurodegeneration

38/100 ✓ Peer-reviewed Disease mechanisms Neurology International

Key finding: Other tauopathies, including Progressive Supranuclear Palsy (PSP), Corticobasal Degeneration (CBD), Frontotemporal Dementia with Parkinsonism (FTDP-17), and Pick’s disease, are distinguished by the predominance of specific Tau isoforms (3R or 4R), cellular distribution, and affected brain regions. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Air pollution and Alzheimer disease phenotype deplete esterified proresolving lipid mediator reserves in the brain

36/100 ✓ Peer-reviewed Disease mechanisms JCI Insight

Key finding: It is unknown whether these deficits are due to reductions in esterified lipid pools, the main source of free bioactive proresolving lipids in the brain, and whether they are related AD pathophysiology.METHODSThis unknown was tested by measuring brain esterified lipid mediators and pathogenic markers of AD in TgF344-AD and WT male and female rats exposed to filtered air or TRAP for 14 months; it was also tested in human postmortem prefrontal cortex of individuals with or without AD.RESULTSSignificant reductions in proresolving lipid mediators esterified to neutral lipids and/or phospholipids were seen in AD and TRAP-exposed female rats, where levels were associated with inflammation, synaptic loss, and impaired glucose metabolism. +1 more finding

• Brain Biology
• Risk Factors

Full summary, score breakdown and related studies → Original source

pS396/pS404 (PHF1) tau vaccine outperforms pS199/pS202 (AT8) in rTg4510 tauopathy model

37/100 ✓ Peer-reviewed Disease mechanisms npj Vaccines

Key finding: Here we report the characterization and comparison of two additional Qβ VLP-based vaccines targeting the dual phosphorylation sites Ser199/Ser202 (Qβ-AT8) and Ser396/Ser404 (Qβ-PHF1). +4 more findings

• Brain Biology
• Prevention

Full summary, score breakdown and related studies → Original source

Linking oxysterols and different stages of mild cognitive impairment: insights from gut metabolites and N6-methyladenosine

41/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer s Research & Therapy

Key finding: EMCIs and LMCIs, especially LMCIs, exhibited poorer performance in almost all global and multidimensional cognitive tests. +4 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Leveraging explainable artificial intelligence with ensemble of deep learning model for dementia prediction to enhance clinical decision support systems

44/100 ✓ Peer-reviewed Digital health tools Scientific Reports

Key finding: For the classification process, the proposed LXAIOA-ADPCM model implements ensemble classifiers such as the bidirectional long short-term memory (BiLSTM), sparse autoencoder (SAE), and temporal convolutional network (TCN) techniques. +4 more findings

• Digital Tools
• Risk Factors

Full summary, score breakdown and related studies → Original source

Predicting dementia in people with Parkinson’s disease

42/100 ✓ Peer-reviewed How common it is npj Parkinson s Disease

Key finding: We concluded that genetic predisposition is the dominant factor, with significant influence from comorbidities. +1 more finding

• Other Dementias
• Risk Factors

Full summary, score breakdown and related studies → Original source

Development and validation of a novel predictive model for dementia risk in middle-aged and elderly depression individuals: a large and longitudinal machine learning cohort study

60/100 ✓ Peer-reviewed How common it is Alzheimer s Research & Therapy

Key finding: During a median follow-up of 7.98 years, 896 incident dementia cases were identified among study participants. +4 more findings

• Risk Factors
• Digital Tools

Full summary, score breakdown and related studies → Original source

Early Detection of Alzheimers Disease Using Deep Learning

28/100 ✓ Peer-reviewed Brain scans and imaging International Research Journal on Advanced Engineering Hub (IRJAEH)

Key finding: Alzheimer's Disease acts as a degenerative brain trauma that results in poor memory, alongside impairing mental functioning.

• Digital Tools
• Diagnosis
• Brain Scans

Full summary, score breakdown and related studies → Original source

Automated remote longitudinal neuropsychological testing with the California Cognitive Assessment Battery

43/100 ✓ Peer-reviewed Getting a diagnosis The Clinical Neuropsychologist

Key finding: The CCAB showed acceptable to good concurrent validity (rs = 0.44-0.79) and reliability (rs = 0.57-0.84). +4 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

A synthesis review of four literature reviews of disaster risk reduction education for children

37/100 ✓ Peer-reviewed Prevention and risk International Journal of Disaster Risk Reduction

Key finding: Program effectiveness was largely self-reported on an individual study-by-study basis across the wide diversity of programmatic elements represented. +4 more findings

• Prevention

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Assessing disaster vulnerability and proposing an adaptive disaster risk reduction framework: the case of Istanbul

39/100 ✓ Peer-reviewed Prevention and risk Natural Hazards

Key finding: The findings support Istanbul's resilience and offer valuable guidance for urban planning and disaster management, both locally and globally.

• Prevention

Full summary, score breakdown and related studies → Original source