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44/100

✓ Peer-reviewed alzhub usefulness score 44 out of 100. How common it is

Topic: Risk, prevention and care in population studies

• CircS was associated with a 40.1 % increased risk of incident all-cause dementia. • A graded increase in dementia risk with escalating severity of CircS. • The presence of ≥ 3 CircS components was significantly associated with dementia. • There was a synergistic effect of CircS and high genetic risk on dementia. Despite growing interest in circadian disturbances as potential triggers for dementia, the specific impact of circadian syndrome (CircS) on dementia incidence remains poorly understood. Moreover, the role of genetic susceptibility modulating these effects remains to be explored. Dementia-free participants from the UK Biobank cohort were included in the analysis. To evaluate the association between CircS and the incidence of dementia, as well as the modifying influence of genetic susceptibility on this relationship, Cox proportional hazards models were utilized. During a median follow-up period of 14.55 years, 3,965 incident dementia cases were documented. CircS was found to significantly increased the risk of incident dementia, with a hazard ratio (HR) of 1.401 (95 % confidence interval [CI]: 1.296, 1.516). Compared to a CircS score of ≤3, mild CircS (HR: 1.259, 95 % CI: 1.146–1.383), moderate CircS (HR: 1.667, 95 % CI: 1.461–1.903), and severe CircS (HR: 2.028, 95 % CI: 1.397–2.944) were all significantly associated with an elevated risk of dementia. There were significant multiplicative interactions between CircS and genetic susceptibility ( P interaction <0.001). Participants with both a high polygenic risk score (PRS) and CircS had the highest risk of incident dementia (HR: 2.551, 95 % CI: 2.169, 3.001), compared to those with a low PRS and no CircS. CircS was associated with an increased risk of dementia, which might be aggravated by genetic susceptibility.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Yu, L., Liu, W. Y., Liao, C., Shen, N., Liu, A., Cheng, L., et al. (2025). The interaction between circadian syndrome and genetic susceptibility in the risk of incident dementia: A longitudinal cohort study. The Journal of Prevention of Alzheimer s Disease. https://doi.org/10.1016/j.tjpad.2025.100089

Vancouver

Yu L, Liu WY, Liao C, Shen N, Liu A, Cheng L, et al. The interaction between circadian syndrome and genetic susceptibility in the risk of incident dementia: A longitudinal cohort study. The Journal of Prevention of Alzheimer s Disease. 2025. doi:10.1016/j.tjpad.2025.100089. PMID: 39922757.

BibTeX

@article{yu2025-39922757,
  author  = {Yu, Linling and Liu, Wei Yong and Liao, Chenqi and Shen, Na and Liu, Anding and Cheng, Liming and Wang, Xiong},
  title   = {{The interaction between circadian syndrome and genetic susceptibility in the risk of incident dementia: A longitudinal cohort study}},
  journal = {The Journal of Prevention of Alzheimer s Disease},
  year    = {2025},
  doi     = {10.1016/j.tjpad.2025.100089},
  pmid    = {39922757},
  url     = {https://doi.org/10.1016/j.tjpad.2025.100089}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

Key findings

• CircS was associated with a 40.1 % increased risk of incident all-cause dementia. • A graded increase in dementia risk with escalating severity of CircS. • The presence of ≥ 3 CircS components was significantly associated with dementia. • There was a synergistic effect of CircS and high genetic risk on dementia.
CircS was found to significantly increased the risk of incident dementia, with a hazard ratio (HR) of 1.401 (95 % confidence interval [CI]: 1.296, 1.516).
Compared to a CircS score of ≤3, mild CircS (HR: 1.259, 95 % CI: 1.146–1.383), moderate CircS (HR: 1.667, 95 % CI: 1.461–1.903), and severe CircS (HR: 2.028, 95 % CI: 1.397–2.944) were all significantly associated with an elevated risk of dementia.
There were significant multiplicative interactions between CircS and genetic susceptibility ( P interaction <0.001).
Participants with both a high polygenic risk score (PRS) and CircS had the highest risk of incident dementia (HR: 2.551, 95 % CI: 2.169, 3.001), compared to those with a low PRS and no CircS.

Why it matters

This longitudinal cohort study found that circadian syndrome was associated with a 40.1% increased risk of incident all-cause dementia, with risk rising as severity increased, and that circadian syndrome and high genetic risk had a synergistic effect. It reports associations and does not test any treatment, cure, or prevention.

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Study details

Effect sizeHR: 1.259; HR: 1.667; HR: 2.028
Evidence strengthModerate

How this study scored 44/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (The Journal of Prevention of Alzheimer s Disease)
Journal's citation record	0 / 4	The Journal of Prevention of Alzheimer s Disease: journal h-index 63 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	3 / 3	Effect reported with a statistic (interval, p-value, ratio or similar)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	2 / 7	Cited 9 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	3.0 citations a year over 3 year(s) since 2025
Impact for its field and year	3 / 6	Cited 5.7× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	1 / 6	Cited by 1 other studies in this library
Still being cited	1 / 4	Cited 9 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Xiong Wang: h-index 35 (OpenAlex, whole career)
Institution's track record	1 / 3	Huazhong University of Science and Technology: institution h-index 934 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 2 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 39922757)
Free to read	2 / 2	Free to read
Total	44 / 100	—

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