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Evaluating the feasibility of a community-adapted multi-domain intervention for dementia prevention in older adults
Yujiro Kuroda, Kosuke Fujita, Taiki Sugimoto, Kazuaki Uchida, Yoko Yokoyama, Taichi Shimazu, Junko Saito, Hidenori Arai et al.. Journal of Alzheimer s Disease, 2025-02-09
Topic: Risk, prevention and care in population studies
BackgroundDementia impacts individuals, families, and society, necessitating effective prevention strategies.ObjectiveTo evaluate the feasibility of a community-adapted multi-domain intervention for dementia prevention among older adults in Obu City, Japan and how uncertainties in implementing definitive trials can be reduced.MethodsA 12-month one-arm intervention trial was conducted with 80 community-dwelling older adults aged 65-86 years from two district regions. The multi-domain intervention included physical exercise, nutrition guidance, cognitive training, social participation, and vascular risk management. The primary outcome was the continuation rate, defined as the proportion of participants attending >60% of classes from the initial assessment to 6 months. Secondary outcomes, such as fidelity, acceptability, and appropriateness, were assessed through qualitative and quantitative evaluations. Additionally, health outcomes, including cognitive function and overall lifestyle, were evaluated.ResultsThe study achieved continuation rates of 75% and 76% at 6 and 12 months, respectively, indicating high feasibility. Participants showed high program acceptability (average acceptance score, 4.4 of 5). Fidelity was high regarding content coverage and duration, although the frequency and coverage varied between study sites. Cognitive function remained stable; food-diversity status improved significantly over the study period, though the absence of a control group limits causal interpretation of these changes.ConclusionsThe community-adapted multi-domain intervention for dementia prevention demonstrated high feasibility and acceptability among older adults. Our findings can help reduce uncertainties and support planning future definitive trials to evaluate the effectiveness of community-based dementia-prevention programs.
Key findings
- Additionally, health outcomes, including cognitive function and overall lifestyle, were evaluated.ResultsThe study achieved continuation rates of 75% and 76% at 6 and 12 months, respectively, indicating high feasibility.
- Cognitive function remained stable; food-diversity status improved significantly over the study period, though the absence of a control group limits causal interpretation of these changes.ConclusionsThe community-adapted multi-domain intervention for dementia prevention demonstrated high feasibility and acceptability among older adults.
- Our findings can help reduce uncertainties and support planning future definitive trials to evaluate the effectiveness of community-based dementia-prevention programs.
Why it matters
This one-arm feasibility trial found that a community multi-domain intervention was feasible, with high continuation and acceptability, and cognitive function remained stable. Because there was no control group, the study cannot show that the intervention prevents dementia or improves cognition.
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Study details
- Evidence strengthLow
How this study scored 38/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Alzheimer s Disease) |
| Journal's citation record | 2 / 4 | Journal of Alzheimer s Disease: journal h-index 218 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 4 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 2.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 1 / 4 | Cited 4 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Takashi Sakurai: h-index 45 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | University of Washington: institution h-index 3,540 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39924864) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 38 / 100 | — |
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Read the original
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Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Kuroda, Y., Fujita, K., Sugimoto, T., Uchida, K., Yokoyama, Y., Shimazu, T., et al. (2025). Evaluating the feasibility of a community-adapted multi-domain intervention for dementia prevention in older adults. Journal of Alzheimer s Disease. https://doi.org/10.1177/13872877251315042
Vancouver
Kuroda Y, Fujita K, Sugimoto T, Uchida K, Yokoyama Y, Shimazu T, et al. Evaluating the feasibility of a community-adapted multi-domain intervention for dementia prevention in older adults. Journal of Alzheimer s Disease. 2025. doi:10.1177/13872877251315042. PMID: 39924864.
BibTeX
@article{kuroda2025-39924864,
author = {Kuroda, Yujiro and Fujita, Kosuke and Sugimoto, Taiki and Uchida, Kazuaki and Yokoyama, Yoko and Shimazu, Taichi and Saito, Junko and Arai, Hidenori and others},
title = {{Evaluating the feasibility of a community-adapted multi-domain intervention for dementia prevention in older adults}},
journal = {Journal of Alzheimer s Disease},
year = {2025},
doi = {10.1177/13872877251315042},
pmid = {39924864},
url = {https://doi.org/10.1177/13872877251315042}
}
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