Newest studies

Regional Brain Metabolism across the Alzheimer's Disease Continuum in Down Syndrome

45/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Annals of neurology

Key finding: The brain metabolic decline in DS with age reflects Alzheimer's pathological processes and involves temporoparietal regions in a similar pattern to that found in other forms of AD. +3 more findings

• Down Syndrome
• Biomarkers

Full summary, score breakdown and related studies → Original source

NLRP3 inflammasome in neuroinflammation and central nervous system diseases

43/100 ✓ Peer-reviewed Inflammation and the immune system Cellular & molecular immunology

Key finding: Recent studies have revealed that the NLRP3 inflammasome is activated in the brain to induce neuroinflammation, leading to further neuronal damage and functional impairment, and contributes to the pathological process of various neurological diseases, such as multiple sclerosis, Parkinson's disease, Alzheimer's disease, and stroke.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Prediction of dementia using CT imaging in stroke (PRODUCTS)

41/100 ✓ Peer-reviewed Vascular contributions European Stroke Journal

Key finding: Among 195 participants, 33% had dementia after 3 years of follow-up. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Kai-Xin-San ameliorates mild cognitive impairment in SAMP8 mice by inhibiting neuroinflammation and pyroptosis via NLRP3/Caspase-1 pathway modulation

37/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in Pharmacology

Key finding: KXS significantly improved spatial memory, working memory, and executive function in SAMP8 mice. +2 more findings

• Brain Biology
• Early Stage

Full summary, score breakdown and related studies → Original source

Psychiatric Disorders Mediate the Association between Floods and Dementia: A Prospective Cohort Study in the UK Biobank

40/100 ✓ Peer-reviewed Long-term cohort studies Environment & Health

Key finding: Psychiatric disorders are associated with an increased risk of subsequent dementia. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Exploration of working memory retrieval stage for mild cognitive impairment: time-varying causality analysis of electroencephalogram based on dynamic brain networks

41/100 ✓ Peer-reviewed Mild cognitive impairment Journal of NeuroEngineering and Rehabilitation

Key finding: Our results showed that: (a) Behavioral data analysis: there were significant differences in accuracy and accuracy / reaction time between MCI and NC in tasks with memory load capacity of low load-four and high load-six, especially in tasks with memory load capacity of four. +4 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Key motor and non-motor features in early dementia with Lewy bodies

50/100 ✓ Peer-reviewed Lewy body dementia Frontiers in Neurology

Key finding: Early-stage DLB closely resembles PD in motor symptoms but has more neuropsychiatric non-motor symptoms compared to PD and overall non-motor symptoms than AD. +2 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Neuropsychiatric symptoms cluster and fluctuate over time in behavioral variant frontotemporal dementia

59/100 ✓ Peer-reviewed Lewy body dementia Psychiatry and Clinical Neurosciences

Key finding: NPS were highly prevalent (≥90%) in early and late bvFTD. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Sympathetic and parasympathetic subtypes of body-first Lewy body disease observed in postmortem tissue from prediagnostic individuals

61/100 ✓ Peer-reviewed Lewy body dementia Nature Neuroscience

Key finding: We observed a clear distinction between brain-first and body-first subtypes in early prediagnostic cases with mild Lewy pathology.

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Urban-rural differences in the health care of people living with dementia and mild cognitive impairment in shared-housing arrangements in Germany – have inequities in urban vs. rural locations been overcome?

60/100 ✓ Peer-reviewed Disparities BMC Health Services Research

Key finding: The majority of the assessed health care data did not show significant differences between urban and rural SHA inhabitants. +4 more findings

• Health Equity
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Associations between Ultrafine Particles and Incident Dementia in Older Adults

45/100 ✓ Peer-reviewed Disparities Environmental Science & Technology

Key finding: Among ∼21 million participants for AD and ∼20 million for ADRD, each interquartile range increase in UFP exposure (3701.6 and 3668.5 particles/cm 3, respectively) was associated with higher AD (HR: 1.026, 95% CI: 1.014–1.038) and ADRD (HR: 1.016, 95% CI: 1.008–1.023) risks. +1 more finding

• Risk Factors

Full summary, score breakdown and related studies → Original source

Conditions for Nutritional Care of Elderly Individuals with Dementia and Their Caregivers: An Exploratory Study

39/100 ✓ Peer-reviewed Caregiving Nutrients

Key finding: Adults of 78.8 years on average, with low to middle socio-economic status, low education levels, and multiple comorbidities, have adverse well-being and support conditions, except for the spiritual component. +4 more findings

• Caregiving
• Lifestyle

Full summary, score breakdown and related studies → Original source

Development and Validation of a 18 F-Flortaucipir PET Visual Stratification Method

47/100 ✓ Peer-reviewed Brain scans and imaging Journal of Nuclear Medicine

Key finding: The median PPA and NPA were 83.4% and 88.9%, respectively, with lower bounds of 2-sided 95% CIs being 50% or greater for all readers. +3 more findings

• Brain Scans
• Treatments
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Lifestyle factors and plasma biomarkers of Alzheimer's disease: A narrative review

43/100 ✓ Peer-reviewed Biomarkers The journal of prevention of Alzheimer's disease

Key finding: Limited evidence suggests that better nutrition is associated with favourable AD plasma biomarker profiles and that PA is associated with less plasma NfL and Aβ, whilst poor sleep is associated with elevated plasma Aβ.

• Biomarkers
• Lifestyle
• Prevention

Full summary, score breakdown and related studies → Original source

Predicting White Matter Hyperintensity: Leveraging Portable MRI for Accessible Brain Health Screening

53/100 ✓ Peer-reviewed Vascular contributions American Journal of Neuroradiology

Key finding: The final model, which included age, systolic blood pressure >140, atrial fibrillation, and tobacco use, achieved an AUC of 0.83 (95% CI 0.75-0.90) in the development cohort (N=143, 62.4±12.6 years, 44% female, 36% non-white race) and 0.85 (95% CI 0.77-0.92) in the validation cohort (N=127, 65.2±16.8 years, 51% female, 34% non-white race), with similar results using WMH measurements derived from cMRI (N=120, p=0.98, AUC=0.86, 95% CI 0.77-0.93). +4 more findings

• Brain Scans
• Risk Factors
• Diagnosis

Full summary, score breakdown and related studies → Original source

Beliefs and attitudes of family caregivers of People with dementia toward advance care planning: A Q methodology study

32/100 ✓ Peer-reviewed End-of-life care Dementia

Key finding: Three types emerged from 24 caregivers through a Varimax rotation and explained 53% of the total variance. +4 more findings

• Caregiving
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Ιnnovative Health Promotion Strategies: A 6-Month Longitudinal Study on Computerized Cognitive Training for Older Adults with Minor Neurocognitive Disorders

38/100 ✓ Peer-reviewed Prevention trials European Journal of Investigation in Health Psychology and Education

Key finding: Statistical analysis showed significant cognitive decline in the non-intervention group in orientation (p = 0.032), language expression (p = 0.008), praxis (p = 0.008), and memory (p = 0.01). +3 more findings

• Lifestyle
• Digital Tools

Full summary, score breakdown and related studies → Original source

Nef is a key player in neuroinflammation and myelin impairment associated with neuroHIV

37/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in Neurology

Key finding: In particular, the severity of HIV-associated neurocognitive disorders (HAND) has been greatly reduced, significantly decreasing the prevalence of HIV-associated dementia [1]. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Incidence and mortality trends of people living with dementia among 7 million individuals over 10 years in Italy: A retrospective cohort study using administrative linked data

51/100 ✓ Peer-reviewed How common it is Annals of Epidemiology

Key finding: Over the last decade, age-standardised dementia incidence estimated rates have decreased by 52.8 % for women and 53.1 % for males. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Changing Story of the Dementia Epidemic

53/100 ✓ Peer-reviewed How common it is JAMA

Key finding: This Viewpoint discusses age-specific dementia prevalence rates, their decline during 40 years, and the subsequent effect on dementia incidence.

Full summary, score breakdown and related studies → Original source

The Annual Incidence of Vascular Dementia and Other Dementias: A Population-Based Study in Eastern Finland

44/100 ✓ Peer-reviewed How common it is Neuroepidemiology

Key finding: The total number of new diagnoses of dementia with a vascular component or vascular alone was 202, with 20 cases attributable to pure VD. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Cellular Senescence Is a Central Driver of Cognitive Disparities in Aging

44/100 ✓ Peer-reviewed Disparities Aging Cell

Key finding: We demonstrate that senolytic treatment is an effective therapeutic strategy to mitigate cognitive impairment by reducing neuroinflammation and associated metabolic disturbances. +1 more finding

• Health Equity
• Brain Biology

Full summary, score breakdown and related studies → Original source

Challenges and Opportunities in Implementing a Multicomponent Dementia Caregiver Program in a Complex Healthcare System

37/100 ✓ Peer-reviewed Caregiving INQUIRY The Journal of Health Care Organization Provision and Financing

Key finding: We interviewed 65 unique informants in 58 interviews (5 VAMC leaders, 36 department leaders, and 17 frontline clinical staff). +4 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

Neuropsychological tests and machine learning: identifying predictors of MCI and dementia progression

40/100 ✓ Peer-reviewed Getting a diagnosis Aging Clinical and Experimental Research

Key finding: The tests qualitatively and statistically associated to a cognitive decline are MMSE, FAB, BSTR, AM, and VSF, of which at least three were considered the most informative also by machine learning. 73% average accuracy was obtained in the diagnosis prediction on three subsets of original and external data. +2 more findings

• Diagnosis
• Digital Tools

Full summary, score breakdown and related studies → Original source

Trazodone and Risk of Orthostatic Hypotension, Syncope and Falls in Geriatric Outpatients with Hypertension

54/100 ✓ Peer-reviewed Clinical safety Drugs & Aging

Key finding: Trazodone users showed lower office diastolic BP (71.8 versus 80.1 mmHg, p = 0.042), a greater systolic and diastolic BP reduction immediately after standing (Δsystolic T0 23.8 versus 14.3 mmHg, p = 0.037; Δdiastolic T0 8.9 versus 1.6 mmHg, p = 0.004) and a greater diastolic BP reduction after 1-min standing (Δdiastolic T1 6.5 versus 0 mmHg, p = 0.029). +3 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source