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56/100

✓ Peer-reviewed alzhub usefulness score 56 out of 100. Getting a diagnosis

Topic: Risk, prevention and care in population studies

During follow-up ranging from 1.0 to 22.9 years, 75 patients (29.88%) converted to AD. Depression onset after age 75 years was significantly associated with a higher risk of AD conversion (hazard ratio [HR], 8.95; 95% confidence interval [CI], 3.41-23.48; p < 0.0001) and a shorter time to conversion compared to onset before age 55 (40.93 vs. 83.40 months). After adjusting for covariates, depression onset after age 75 remained significantly associated with AD conversion (adjusted HR, 5.20; 95% CI, 1.04-25.93; p = 0.0431). This group also had milder depressive symptoms and a higher prevalence of hypertension and cerebrovascular disease than those with depression onset before 55 years of age. The onset of depression after the age of 75 years was strongly associated with an increased risk of AD and a shorter time to dementia onset. Individuals with depression onset after age 75 appear more closely linked to vascular comorbidities, while those with depression onset before age 55 are characterized by severe and recurrent depressive episodes. The mechanisms underlying AD in individuals with depression may differ from those in individuals without prior depression.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Jang, Y. J., Kim, M.-J., Moon, Y. K., Lim, S., & Kim, D. K. (2025). Changes in dementia risk along with onset age of depression: a longitudinal cohort study of elderly depressed patients. BMC Psychiatry. https://doi.org/10.1186/s12888-025-06683-w

Vancouver

Jang YJ, Kim M.-J, Moon YK, Lim S, Kim DK. Changes in dementia risk along with onset age of depression: a longitudinal cohort study of elderly depressed patients. BMC Psychiatry. 2025. doi:10.1186/s12888-025-06683-w. PMID: 40098109.

BibTeX

@article{jang2025-40098109,
  author  = {Jang, Yoo Jin and Kim, Min-Ji and Moon, Young Kyung and Lim, Shinn‐Won and Kim, Doh Kwan},
  title   = {{Changes in dementia risk along with onset age of depression: a longitudinal cohort study of elderly depressed patients}},
  journal = {BMC Psychiatry},
  year    = {2025},
  doi     = {10.1186/s12888-025-06683-w},
  pmid    = {40098109},
  url     = {https://doi.org/10.1186/s12888-025-06683-w}
}

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Key findings

During follow-up ranging from 1.0 to 22.9 years, 75 patients (29.88%) converted to AD.
Depression onset after age 75 years was significantly associated with a higher risk of AD conversion (hazard ratio [HR], 8.95; 95% confidence interval [CI], 3.41-23.48; p < 0.0001) and a shorter time to conversion compared to onset before age 55 (40.93 vs. 83.40 months).
After adjusting for covariates, depression onset after age 75 remained significantly associated with AD conversion (adjusted HR, 5.20; 95% CI, 1.04-25.93; p = 0.0431).
This group also had milder depressive symptoms and a higher prevalence of hypertension and cerebrovascular disease than those with depression onset before 55 years of age.
The onset of depression after the age of 75 years was strongly associated with an increased risk of AD and a shorter time to dementia onset.

Why it matters

This longitudinal study found that depression onset after age 75 was strongly associated with an increased risk of Alzheimer's disease and a shorter time to dementia onset. It suggests that the mechanisms underlying Alzheimer's disease in people with depression may differ from those without prior depression, but it does not test any treatment or prevention.

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Study details

Study designlongitudinal study
Participants75
Effect size29.88%
Evidence strengthModerate

How this study scored 56/100

Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (BMC Psychiatry)
Journal's citation record	2 / 4	BMC Psychiatry: journal h-index 198 (OpenAlex, 2026-10-29)
Study design	7 / 12	A longitudinal study following the same people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	1 / 4	75 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	2 / 7	Cited 12 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	4.0 citations a year over 3 year(s) since 2025
Impact for its field and year	3 / 6	Cited 7.6× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 12 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Doh Kwan Kim: h-index 33 (OpenAlex, whole career)
Institution's track record	1 / 3	Sungkyunkwan University: institution h-index 788 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 4 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40098109)
Free to read	2 / 2	Free to read
Total	56 / 100	—

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