Nickel-based nanomaterials: a… | 2025

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47/100

✓ Peer-reviewed alzhub usefulness score 47 out of 100. Prevention and risk

Topic: Risk, prevention and care in population studies

Nickel-based nanomaterials (NBNs) have seen a surge in usage across a variety of applications. However, the widespread use of NBNs has led to increased human exposure, raising questions about their associated health risks, both in the short and long term. Additionally, the spread of NBNs in the environment has attracted considerable attention, emerging as a vital focus for research and development. This review aims to provide an in-depth assessment of the current understanding of NBNs toxicity, the mechanisms underlying their toxicological effects, and the strategies for mitigating associated health risks. We begin by examining the physicochemical properties of NBNs, such as particle size, composition and surface functionalization, which are key determinants of their biological interactions and toxicity. Then, through an extensive analysis of in vitro and in vivo studies, we highlight the adverse effects of NBNs exposure, including the generation of reactive oxygen species (ROS), oxidative stress, inflammation, cytotoxicity, genotoxicity, and immunotoxicity. To address the potential health risks associated with NBNs, we propose future strategies for risk prevention, including the development of safer nanomaterial designs, implementation of stringent regulatory guidelines, and advancement of novel toxicity testing approaches.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Zhou, X., Liao, J., Lei, Z., Yao, H., Zhao, L., Yang, C. C., et al. (2025). Nickel-based nanomaterials: a comprehensive analysis of risk assessment, toxicity mechanisms, and future strategies for health risk prevention. Journal of Nanobiotechnology. https://doi.org/10.1186/s12951-025-03248-7

Vancouver

Zhou X, Liao J, Lei Z, Yao H, Zhao L, Yang CC, et al. Nickel-based nanomaterials: a comprehensive analysis of risk assessment, toxicity mechanisms, and future strategies for health risk prevention. Journal of Nanobiotechnology. 2025. doi:10.1186/s12951-025-03248-7. PMID: 40087769.

BibTeX

@article{zhou2025-40087769,
  author  = {Zhou, Xiaoting and Liao, Jiaqi and Lei, Zipeng and Yao, Huiqin and Zhao, Le and Yang, Chun Cheng and Zu, Yan and Zhao, Yuliang},
  title   = {{Nickel-based nanomaterials: a comprehensive analysis of risk assessment, toxicity mechanisms, and future strategies for health risk prevention}},
  journal = {Journal of Nanobiotechnology},
  year    = {2025},
  doi     = {10.1186/s12951-025-03248-7},
  pmid    = {40087769},
  url     = {https://doi.org/10.1186/s12951-025-03248-7}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

Key findings

To address the potential health risks associated with NBNs, we propose future strategies for risk prevention, including the development of safer nanomaterial designs, implementation of stringent regulatory guidelines, and advancement of novel toxicity testing approaches.

Why it matters

This review is about the health risks of nickel-based nanomaterials, not Alzheimer's disease. It describes toxic effects seen in laboratory and animal studies, including oxidative stress, inflammation and genotoxicity, and proposes safer designs, stricter regulation and new toxicity testing.

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Study details

Evidence strengthLow

How this study scored 47/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of Nanobiotechnology)
Journal's citation record	2 / 4	Journal of Nanobiotechnology: journal h-index 174 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	3 / 7	Cited 31 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	10.3 citations a year over 3 year(s) since 2025
Impact for its field and year	3 / 6	Cited 6.5× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	2 / 4	Cited 31 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Yuliang Zhao: h-index 145 (OpenAlex, whole career)
Institution's track record	2 / 3	Chinese Academy of Sciences: institution h-index 1,801 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 7 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40087769)
Free to read	2 / 2	Free to read
Total	47 / 100	—

What each of these 20 components measures, and what this score is not →

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Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

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