Newest studies

A Cost-Minimization Analysis of Teleconsultation Versus In-Person Care for Chronic Diseases and Rehabilitation in Medically Underserved Areas of South Korea

43/100 ✓ Peer-reviewed Disparities Healthcare

Key finding: Using data from South Korea’s 2018 teleconsultation pilot program involving 1232 patients, the analysis revealed that teleconsultation reduced societal costs per consultation by USD 7.92 for chronic diseases, USD 27.30 for dementia care, and USD 9.61 for rehabilitation. +3 more findings

• Health Equity
• Policy

Full summary, score breakdown and related studies → Original source

Use of Feeding Tubes Among Hospitalized Older Adults With Dementia

57/100 ✓ Peer-reviewed Disparities JAMA Network Open

Key finding: Among 143 331 older adults with dementia (83 536 [58.3%] female; mean [SD] age, 83.8 [7.5] years), 1312 (0.9%) received a feeding tube in hospital and 142 019 (99.1%) did not. +4 more findings

• Care Services
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Disproportionately Enlarged Subarachnoid-Space Hydrocephalus on MRI in Pathologically Confirmed Progressive Supranuclear Palsy

46/100 ✓ Peer-reviewed Brain scans and imaging Neurology Clinical Practice

Key finding: These findings suggest that DESH and high EI, often considered biomarkers for iNPH, may lack specificity and may be found in a subset of patients with PSP or LBD leading to unnecessary neurosurgery for iNPH.

• Brain Scans

Full summary, score breakdown and related studies → Original source

Altered Clearance in Alzheimer's Disease and Cerebral Amyloid Angiopathy

43/100 ✓ Peer-reviewed Vascular contributions Neuroimaging clinics of North America

Key finding: With our focus on Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA), the authors herein provided a comprehensive overview of impaired amyloid beta and tau clearance pathways observed through advanced neuroimaging techniques such as dynamic contrast-enhanced MR imaging, arterial spin labeling, phase contrast MR imaging, PET, and functional MR imaging. +1 more finding

• Brain Scans

Full summary, score breakdown and related studies → Original source

Drug repurposing for Alzheimer's disease and other neurodegenerative disorders

46/100 ✓ Peer-reviewed Drug development Nature communications

Key finding: Repurposed drugs provide a rich source of potential therapies for Alzheimer's disease (AD) and other neurodegenerative disorders (NDD). +4 more findings

• Treatments
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Altered Clearance and Amyloid-Related Imaging Abnormalities

43/100 ✓ Peer-reviewed Treatments Neuroimaging clinics of North America

Key finding: Amyloid-related imaging abnormalities (ARIA) are parenchymal edema/effusion and hemorrhage that occur as side effects of immunotherapies targeting beta-amyloid for patients with Alzheimer's disease (AD). +2 more findings

• Side Effects
• Brain Scans

Full summary, score breakdown and related studies → Original source

Integrating the environmental and genetic architectures of aging and mortality

66/100 ✓ Peer-reviewed Genetics Nature medicine

Key finding: To systematically identify environmental exposures associated with aging in the UK Biobank, we first conducted an exposome-wide analysis of all-cause mortality (n = 492,567) and then assessed the associations of these exposures with a proteomic age clock (n = 45,441), identifying 25 independent exposures associated with mortality and proteomic aging. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

The impact of kidney function on Alzheimer's disease blood biomarkers: implications for predicting amyloid-β positivity

57/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

Key finding: We found that kidney function seems to be associated with AD blood biomarker concentrations. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Integrating Machine Learning and Environmental and Genetic Risk Factors for the Early Detection of Preclinical Alzheimer's Disease

65/100 ✓ Peer-reviewed Risk factors The journals of gerontology. Series B, Psychological sciences and social sciences

Key finding: The ensemble model demonstrated superior predictive performance, highlighting the potential of integrating multiple models for early AD detection. +1 more finding

• Risk Factors
• Diagnosis
• Early Stage

Full summary, score breakdown and related studies → Original source

Unlocking ocular biomarkers for early detection of Alzheimer's disease

38/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Recent evidence suggests that ocular testing holds promise as a non-invasive and cost-effective method for the early detection of Alzheimer's disease (AD).

• Diagnosis
• Biomarkers
• Policy

Full summary, score breakdown and related studies → Original source

HEaring and LIstening eXperience (HELIX): Evaluation of a co-designed serious game for auditory-cognitive training

44/100 ✓ Peer-reviewed Prevention trials Quarterly Journal of Experimental Psychology

Key finding: An improvement in the performance of the Digit-Triplet-Test, measured 4 and 8 weeks after the baseline, was found within the training group; however, this improvement was not significant between the training and control groups. +2 more findings

• Clinical Trials
• Lifestyle

Full summary, score breakdown and related studies → Original source

Predicting the Beneficial Effects of Cognitive Stimulation and Transcranial Direct Current Stimulation in Amnestic Mild Cognitive Impairment with Clinical, Inflammation, and Human Microglia Exposed to Serum as Potential Markers: A Double-Blind Placebo-Controlled Randomized Clinical Trial

43/100 ✓ Peer-reviewed Mild cognitive impairment International Journal of Molecular Sciences

Key finding: Cognitive stimulation (CS) and transcranial direct current stimulation (tDCS) applied to the left dorsolateral prefrontal cortex (l-DLPFC) show promise, but the results are heterogeneous. +3 more findings

• Clinical Trials
• Brain Biology
• Early Stage

Full summary, score breakdown and related studies → Original source

Talking during walking: the diagnostic potential of turn dynamics in Alzheimer’s disease, mild cognitive impairment and cognitive aging

44/100 ✓ Peer-reviewed Mild cognitive impairment Frontiers in Aging Neuroscience

Key finding: Linear regression analysis indicated that turn dynamics had stronger correlations with executive function and working memory, suggesting a more pronounced relationship between cognitive performance and turn features than gait variables. +2 more findings

• Diagnosis
• Early Stage

Full summary, score breakdown and related studies → Original source

Diagnosis, Treatment and Future Perspectives in Artificial Intelligence and Neuronal Diseases

28/100 ✓ Peer-reviewed Digital health tools International Journal of Emerging Multidiciplinaries Biomedical and Clinical Research

Key finding: While this process allows machine learning models to make more precise and reliable diagnoses, systems developed on the basis of Dr. +4 more findings

• Digital Tools
• Treatments
• Diagnosis

Full summary, score breakdown and related studies → Original source

Balancing Health and Sustainability: Assessing the Benefits of Plant-Based Diets and the Risk of Pesticide Residues

43/100 ✓ Peer-reviewed Prevention and risk Nutrients

Key finding: This study concludes that the transition towards sustainable agriculture and food production is essential for reducing pesticide residues in food, thereby protecting human health, wildlife populations, and the environment.

• Lifestyle

Full summary, score breakdown and related studies → Original source

Examining equity in service use across socioeconomic status in people with dementia

42/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia Behavior & Socioeconomics of Aging

Key finding: Stark differences across SES in service use by people with dementia may indicate different health needs and/or allude to pervasive health inequities. +2 more findings

• Health Equity
• Care Services

Full summary, score breakdown and related studies → Original source

TREM2 promotes lung fibrosis via controlling alveolar macrophage survival and pro-fibrotic activity

54/100 ✓ Peer-reviewed TREM2 and immune genetics Nature communications

Key finding: However, the mechanisms regulating their pro-fibrotic behavior and survival remain unclear, and effective therapeutic strategies are lacking. +3 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

CSF IL-6, GDF-15, GFAP and NfL levels in early Alzheimer disease: a pilot study

47/100 ✓ Peer-reviewed Biomarkers Therapeutic advances in neurological disorders

Key finding: MMSE score showed a positive correlation with the Aβ 1-42 concentrations ( r = 0.485; p r = -0.418; p = 0.002). +4 more findings

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

Personalized Multi-Domain Digital Platform for Dementia Prevention

43/100 ✓ Peer-reviewed Prevention trials Studies in health technology and informatics

Key finding: The Personalized Multi-Domain Digital Platform for Dementia Prevention (PM(DP)*2) is a conceptualized evidence-based initiative designed to reduce dementia burden through tailored interventions. +2 more findings

• Prevention
• Digital Tools

Full summary, score breakdown and related studies → Original source

Dementia as a predictor of palliative care: Uncovering patient patterns based on German claims data

44/100 ✓ Peer-reviewed End-of-life care BMC Palliative Care

Key finding: The study cohort for the analysis of inpatient palliative care comprised 43,896 patients, while the cohort for the analysis of outpatient palliative care included a total of 37,430 patients. +4 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Patient characteristics, behavior, and discharge locations of patients with dementia and very severe challenging behavior

46/100 ✓ Peer-reviewed Clinical safety Aging & Mental Health

Key finding: Nine in ten patients had moderately severe or severe cognitive decline. +4 more findings

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Classifying Alzheimer’s wandering and apathetic behaviours using indoor and outdoor localization data

36/100 ✓ Peer-reviewed Clinical safety Journal of Ambient Intelligence and Smart Environments

Key finding: Classification results were compared with the observations made by healthcare operators and physicians. +1 more finding

• Caregiving

Full summary, score breakdown and related studies → Original source

Investigating the Impact of NMDA Receptor Organization and Biological Sex in the APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease

43/100 ✓ Peer-reviewed Disease mechanisms International Journal of Molecular Sciences

Key finding: These findings emphasize the importance of targeting synaptic receptor trafficking to address AD-related memory deficits, potentially offering a therapeutic approach for both sexes.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Gas Chromatography‐Mass Spectrometry Profiling of Crateva magna Leaf Lipophilic Extract and Evaluation of Its Anti‐Alzheimer and Cytotoxic Properties

41/100 ✓ Peer-reviewed Risk genes beyond APOE Chemistry & Biodiversity

Key finding: These findings indicate that CMHF may possess anti‐Alzheimer efficacy. +3 more findings

Full summary, score breakdown and related studies → Original source

IRMA: Machine learning-based harmonization of $$^{18}$$F-FDG PET brain scans in multi-center studies

41/100 ✓ Peer-reviewed Digital health tools European Journal of Nuclear Medicine and Molecular Imaging

Key finding: IRMA can be used to learn and disregard center-specific information in features extracted from brain $$^{18}$$ 18 F-FDG PET scans, while retaining disease-specific information. +1 more finding

• Brain Scans
• Digital Tools
• Other Dementias

Full summary, score breakdown and related studies → Original source