Newest studies

Boosting Cognitive Training through Social Engagement: Impacts on Older Adults With Subjective Cognitive Decline

57/100 ✓ Peer-reviewed Prevention trials Sage Open Aging

Key finding: Both groups showed significant cognitive improvements (increased MoCA, decreased SCD-Q) post-intervention. +3 more findings

• Lifestyle
• Clinical Trials
• Early Stage

Full summary, score breakdown and related studies → Original source

Twenty years of therapeutic development in tauopathy mouse models: a scoping review

43/100 ✓ Peer-reviewed Disease mechanisms Alzheimer s & Dementia

Key finding: HIGHLIGHTS: Two decades of therapeutic research in tauopathy mouse models were reviewed. +4 more findings

• Brain Biology
• Treatments

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In Vivo Cortical Microstructure: Relationships With Tauopathy and Cognitive Impairment in the Elderly

55/100 ✓ Peer-reviewed Disease mechanisms Journal of Neurochemistry

Key finding: Our results suggest that microstructural features derived from NODDI such as fISO might be useful adjunct markers to tau, which needs to be confirmed in longitudinal studies. +1 more finding

• Brain Scans

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Cannabidiol and Alzheimer Disease: A Comprehensive Review and In Silico Insights Into Molecular Interactions

36/100 ✓ Peer-reviewed Inflammation and the immune system European Journal of Neuroscience

Key finding: The primary therapeutic approach for AD involves the use of anticholinesterase agents; however, these treatments are associated with adverse effects, and their efficacy has been increasingly questioned.

• Brain Biology

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Cohort Profile Update: The ‘Seguimiento Universidad de Navarra’ (SUN) study after 24 years of follow-up

59/100 ✓ Peer-reviewed Risk genes beyond APOE International Journal of Epidemiology

Key finding: In 2018, Carlos et al. [2] reviewed 21 studies from the SUN project that focused on the association between the MDP and several incident chronic diseases, concluding that high Mediterranean diet adherence was associated with a lower incidence of all-cause mortality, cardiovascular disease, type 2 diabetes, weight gain, metabolic syndrome, depression, cognitive decline, and nephrolithiasis, and with a lower heart rate and mitigation of the effects of obesity on cardiovascular disease (CVD) and type 2 diabetes, and our results suggested that the Mediterranean diet may improve fertility. +4 more findings

• Risk Factors
• Lifestyle

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Evaluating the effects of liraglutide, empagliflozin and linagliptin on mild cognitive impairment remission in patients with type 2 diabetes (LIGHT-MCI): study protocol for a multicentre, randomised controlled trial with an extension phase

46/100 ✓ Peer-reviewed Mild cognitive impairment BMJ Open

Key finding: Diabetes is a significant modifiable risk factor for cognitive dysfunction.

• Clinical Trials
• Early Stage
• Risk Factors

Full summary, score breakdown and related studies → Original source

Sex‐specific association of depressive symptom trajectories with cognitive decline and clinical progression in mild cognitive impairment

52/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer s & Dementia

Key finding: In men, increasing depressive symptoms were associated with significantly steeper rates of cognitive decline, as measured by global cognitive and functional outcomes, and with an increased risk of dementia compared to consistently low depressive symptoms. +4 more findings

• Early Stage
• Risk Factors

Full summary, score breakdown and related studies → Original source

Criminal Behavior in Frontotemporal Dementia: A Multimodal MRI Study

45/100 ✓ Peer-reviewed Lewy body dementia Human Brain Mapping

Key finding: Recent work suggests that impairment in emotional processing, along with disinhibition, constitutes the necessary elements for CB in bvFTD. +3 more findings

• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source

Impact of hippocampal α‐synuclein oligomers on cognitive trajectory in patients with dementia with Lewy bodies

43/100 ✓ Peer-reviewed Lewy body dementia Alzheimer s & Dementia

Key finding: DLB with rapid cognitive decline showed greater CA1 αSYN oligomer burden (p = 0.029) and tau burden (p = 0.029) than DLB with slow decline. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Bezafibrate treatment rescues neurodevelopmental and neurodegenerative defects in 3D cortical organoid model of MAPT frontotemporal dementia

39/100 ✓ Peer-reviewed Lewy body dementia Alzheimer s & Dementia

Key finding: Tau mutant cortical organoids showed altered mitochondrial function and gene expression related to neuronal development, with synaptic markers and neuronal activity reduction. +4 more findings

• Treatments
• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Multi-modal comparative phenotyping of knock-in mouse models of frontotemporal dementia/amyotrophic lateral sclerosis

49/100 ✓ Peer-reviewed Lewy body dementia Disease Models & Mechanisms

Key finding: We found that the C9orf72GR400/+ model exhibits age-related deficit in short-term memory and that parental genotype affects exploration activity in offspring. +2 more findings

• Other Dementias
• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Dementia With Lewy Bodies

30/100 ✓ Peer-reviewed Lewy body dementia CONTINUUM Lifelong Learning in Neurology

Key finding: Frequently occurring copathology, most commonly with Alzheimer disease, leads to greater cognitive decline, increased likelihood of admission to a long-term care facility, and a higher risk of mortality.

• Other Dementias

Full summary, score breakdown and related studies → Original source

Neurodevelopmental Vulnerability in Alzheimer's Disease and Frontotemporal Dementia

46/100 ✓ Peer-reviewed Lewy body dementia European Journal of Neurology

Key finding: = 0.205; p = 0.651); and between typical (21%) and atypical (11%) subgroups (Fisher's test, p = 0.184). +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Glymphatic activity in behavioral variant frontotemporal dementia: Link with vascular function and astrocytic activation

46/100 ✓ Peer-reviewed Lewy body dementia Alzheimer s & Dementia

Key finding: Glymphatic activity in bvFTD correlated strongly with vascular dysfunction and astrocytic activation, and was associated with brain changes and clinical severity. +4 more findings

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Fourteen years later: Reviewing the diagnostic criteria for behavioral‐variant frontotemporal dementia

49/100 ✓ Peer-reviewed Lewy body dementia Alzheimer s & Dementia

Key finding: Frequency of diagnostic criteria ranged from 89% (apathy; empathy loss) to 14.5% (dysexecutive profile), and 78 patients met at least four criteria. +4 more findings

• Diagnosis
• Other Dementias

Full summary, score breakdown and related studies → Original source

Cardiovascular contributions to dementia: Examining sex differences and female‐specific factors

48/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: We offer recommendations to address these gaps and promote the use of sex-informed methods for studying cardiovascular contributions to AD/ADRD in women, which is essential for developing precision strategies to improve outcomes for all individuals at risk of dementia. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

299. SENSORS IN-HOME FOR ELDER WELLBEING (SINEW): DIGITAL PHENOTYPING AND ARTIFICIAL INTELLIGENCE FOR EARLY DETECTION OF DEMENTIA

49/100 ✓ Peer-reviewed Digital health tools The International Journal of Neuropsychopharmacology

Key finding: Early identification of individuals at increased risk of mild cognitive impairment (MCI), a pre-dementia state, can provide a critical window for prompt intervention to prevent or reverse disease progression. +4 more findings

• Digital Tools
• Diagnosis

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Machine learning diagnosis of cognitive impairment and dementia in harmonized older adult cohorts

48/100 ✓ Peer-reviewed Digital health tools Alzheimer s & Dementia

Key finding: Measures of cognition were especially important predictive features of clinical diagnosis. +4 more findings

• Digital Tools
• Diagnosis

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Enhancing the validity of CAIDE dementia risk scores with resting heart rate and machine learning: An analysis from the National Alzheimer's Coordinating Center across all races/ethnicities

43/100 ✓ Peer-reviewed Disparities Alzheimer s & Dementia

Key finding: Incorporating RHR into the CAIDE model significantly improved predictive accuracy across Black African, Asian, White, and Native Hawaiian populations (mean AUC range: 0.80-0.91). +4 more findings

• Risk Factors
• Health Equity
• Digital Tools

Full summary, score breakdown and related studies → Original source

Age at First Childbirth and Dementia Risk: A Cross‐Sectional Ecological Analysis of Female Prevalence, Sex Disparities, and Public Health Implications

39/100 ✓ Peer-reviewed Disparities Health Science Reports

Key finding: Subgroup analyses revealed stronger associations in LMICs than in high-income countries. +4 more findings

• Health Equity

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Toward compassionate communication: a rapid review on facilitating the dementia disclosure process

55/100 ✓ Peer-reviewed Disparities Alzheimer s & Dementia

Key finding: Four themes emerged: (1) setting up appointments, (2) appointment content, (3) overall approach, and (4) cultural competence in dementia disclosure. +1 more finding

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Association of epigenetic aging with plasma biomarkers of amyloid, tau, neurodegeneration, and neuroinflammation in Hispanic/Latino adults

41/100 ✓ Peer-reviewed Disparities Clinical Epigenetics

Key finding: Blood-based biomarkers hold significant promise for the early detection and diagnosis of Alzheimer’s disease (AD) and other dementias. +4 more findings

• Health Equity
• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

Mental and physical health of US rural/urban caregivers of persons with dementia

44/100 ✓ Peer-reviewed Disparities PLoS ONE

Key finding: Approximately, 25.7% of rural and 20.8% of urban caregivers reported ≥14 PMHD while 25% of rural and 10% of urban caregivers reported ≥14 PPHD. +4 more findings

• Health Equity
• Caregiving

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Validity and reliability of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) for dementia assessment in rural South Africa

52/100 ✓ Peer-reviewed Disparities Alzheimer s & Dementia

Key finding: Index participants averaged 71.9 years, with > 50% lacking formal education. +4 more findings

• Health Equity

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xEEGNet: towards explainable AI in EEG dementia classification

42/100 ✓ Peer-reviewed Disparities Journal of Neural Engineering

Key finding: The capability of xEEGNet to filter specific EEG bands, learns band specific topographies and use the right EEG spectral bands for disease classification demonstrates its interpretability. +2 more findings

• Digital Tools

Full summary, score breakdown and related studies → Original source