Home › Research › Mild cognitive impairment
Exploring the neuromagnetic signatures of cognitive decline from mild cognitive impairment to Alzheimer's disease dementia
Sinead Gaubert, Pilar Garcés, Joerg F. Hipp, Ricardo Bruña, María Eugenia López, Fernando Maestú, Delshad Vaghari, Richard N. Henson et al.. EBioMedicine, 2025-03-29
Topic: Amyloid, tau and blood-test diagnosis
MEG 16-38Hz spectral power, particularly over parieto-occipital magnetometers, was significantly reduced in the AD progression group. In logistic regression models, decreased MEG 16-38Hz spectral power and reduced hippocampal volume/total grey matter ratio on MRI were independently linked to higher AD progression risk. The data-driven classification model confirmed, among other factors, the complementary information of MEG covariance (AUC = 0.74, SD = 0.13) and MRI cortical volumes (AUC = 0.77, SD = 0.14) to predict AD progression. Combining all inputs led to markedly improved classification scores (AUC = 0.81, SD = 0.12). These findings highlight the potential of spectral power and covariance as robust non-invasive electrophysiological biomarkers to predict AD progression, complementing other diagnostic measures, including cognitive scores and MRI. FUNDING: This work was supported by: Fondation pour la Recherche Médicale (grant FDM202106013579).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Gaubert, S., Garcés, P., Hipp, J. F., Bruña, R., López, M. E., Maestú, F., et al. (2025). Exploring the neuromagnetic signatures of cognitive decline from mild cognitive impairment to Alzheimer's disease dementia. EBioMedicine. https://doi.org/10.1016/j.ebiom.2025.105659
Vancouver
Gaubert S, Garcés P, Hipp JF, Bruña R, López ME, Maestú F, et al. Exploring the neuromagnetic signatures of cognitive decline from mild cognitive impairment to Alzheimer's disease dementia. EBioMedicine. 2025. doi:10.1016/j.ebiom.2025.105659. PMID: 40153923.
BibTeX
@article{gaubert2025-40153923,
author = {Gaubert, Sinead and Garcés, Pilar and Hipp, Joerg F. and Bruña, Ricardo and López, María Eugenia and Maestú, Fernando and Vaghari, Delshad and Henson, Richard N. and others},
title = {{Exploring the neuromagnetic signatures of cognitive decline from mild cognitive impairment to Alzheimer's disease dementia}},
journal = {EBioMedicine},
year = {2025},
doi = {10.1016/j.ebiom.2025.105659},
pmid = {40153923},
url = {https://doi.org/10.1016/j.ebiom.2025.105659}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- MEG 16-38Hz spectral power, particularly over parieto-occipital magnetometers, was significantly reduced in the AD progression group.
- In logistic regression models, decreased MEG 16-38Hz spectral power and reduced hippocampal volume/total grey matter ratio on MRI were independently linked to higher AD progression risk.
- The data-driven classification model confirmed, among other factors, the complementary information of MEG covariance (AUC = 0.74, SD = 0.13) and MRI cortical volumes (AUC = 0.77, SD = 0.14) to predict AD progression.
- Combining all inputs led to markedly improved classification scores (AUC = 0.81, SD = 0.12).
- These findings highlight the potential of spectral power and covariance as robust non-invasive electrophysiological biomarkers to predict AD progression, complementing other diagnostic measures, including cognitive scores and MRI.
Why it matters
Reduced MEG spectral power and reduced hippocampal volume relative to total grey matter were independently linked to higher risk of progression to Alzheimer's disease dementia. Combining MEG and MRI measures improved prediction, but this is a biomarker study and does not test any treatment, cure or prevention.
Study details
- Participants117
- Effect sizeAUC = 0.74; AUC = 0.77; AUC = 0.81
- Evidence strengthLow
How this study scored 50/100
Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (EBioMedicine) |
| Journal's citation record | 2 / 4 | EBioMedicine: journal h-index 181 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 117 participants |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 10 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 3.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 3 / 6 | Cited 6.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 10 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Denis Alexander Engemann: h-index 29 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Inserm: institution h-index 1,988 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 9 institution(s) in 4 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40153923) |
| Free to read | 2 / 2 | Free to read |
| Total | 50 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Related
Studies in the library that share something with this one. The line above each title says what.
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here. Showing 12 of 16.
Related studies in Mild cognitive impairment
Also tagged “mini-mental”
840 studies in the library carry the topic tag “mini-mental”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 840 tagged studies.