Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 7,301–7,325 of 27,380 studies, newest first · page 293 of 1096.
October 2023 8
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2023-10-01
Validation of 3- and 5-point severity scales to assess ARIA-E
53/100 ✓ Peer-reviewed Treatments Alzheimer's & dementia (Amsterdam, Netherlands)
Key finding: Our study suggests that SSAE-3 and SSAE-5 are valid ARIA-E rating scales for use in routine clinical practice by experienced radiologists in specialized settings. +3 more findings
Full summary, score breakdown and related studies → Original source
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2023-10-01
The amyloid cascade hypothesis: an updated critical review
43/100 ✓ Peer-reviewed Treatments Brain : a journal of neurology
Key finding: However, while Aβ may contribute to disease, genetic, clinical, imaging and biochemical data suggest a more complex aetiology. +2 more findings
Full summary, score breakdown and related studies → Original source
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2023-10-01
Immune profiling of murine cardiac leukocytes identifies triggering receptor expressed on myeloid cells 2 as a novel mediator of hypertensive heart failure
40/100 ✓ Peer-reviewed TREM2 and immune genetics Cardiovascular research
Key finding: Our data provide an atlas of immunological alterations that can lead to improved diagnostic and therapeutic strategies for HFpEF. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-10-01
Dietary pattern, food, and nutritional supplement effects on cognitive outcomes in mild cognitive impairment: a systematic review of previous reviews
79/100 ✓ Peer-reviewed Prevention trials Nutrition reviews
Key finding: Few nutritional interventions were found to convincingly improve cognition of individuals with MCI. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-10-01
H - 09 Neighborhood Disadvantage, Education Quality, and Cognitive Function in Community-Dwelling Black and White Older Adults with Metabolic Syndrome
28/100 ✓ Peer-reviewed Risk factors Archives of Clinical Neuropsychology
Key finding: Neighborhood disadvantage was selectively associated with cognitive measures heavily influenced by executive function, namely using an efficient word generation strategy, and incorporating feedback to guide problem-solving. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-10-01
Increased Medial Temporal Tau Positron Emission Tomography Uptake in the Absence of Amyloid-β Positivity
69/100 ✓ Peer-reviewed Tau biomarkers JAMA neurology
Key finding: An increased tau positron emission tomography (PET) signal in the medial temporal lobe (MTL) has been observed in older individuals in the absence of amyloid-β (Aβ) pathology. +3 more findings
Full summary, score breakdown and related studies → Original source
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2023-10-01
New Horizons: Gonadotropin-Releasing Hormone and Cognition
44/100 ✓ Peer-reviewed Down syndrome and Alzheimer's The Journal of clinical endocrinology and metabolism
Key finding: Two recent studies suggest that, in addition to controlling reproduction, the neurons in the brain that produce GnRH are also involved in the control of postnatal brain maturation, odor discrimination, and adult cognition. +1 more finding
Full summary, score breakdown and related studies → Original source
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2023-10-01
Demographic and Clinical Characteristics Associated With Serum GFAP Levels in an Ethnically Diverse Cohort
48/100 ✓ Peer-reviewed Biomarkers Neurology
Key finding: A total of 1,156 Mexican American and 587 non-Hispanic White participants were included (mean age = 68 years, standard deviation = 10; 65% female). +1 more finding
Full summary, score breakdown and related studies → Original source
September 2023 17
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2023-09-30
TDP-43 pathology is associated with increased tau burdens and seeding
52/100 ✓ Peer-reviewed Brain tissue and pathology Molecular neurodegeneration
Key finding: We found that AD cases with comorbid LATE-NC, AD(LATE-NC+), have increased burdens of pretangles and/or NFTs as well as increased brain levels of p-tau199, compared to AD(LATE-NC-) cases and controls. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-09-30
Targeting immunometabolic pathways for combination therapy in Alzheimer's disease
47/100 ✓ Peer-reviewed Treatments Alzheimer's & dementia (New York, N. Y.)
Key finding: Despite successfully clearing amyloid from the brain, however, only modest symptomatic improvement has been demonstrated, and treatment-related side effects such as amyloid-related imaging abnormalities (ARIA) limit use for some. +2 more findings
Full summary, score breakdown and related studies → Original source
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2023-09-30
Amyloid Precursor Protein and Alzheimer's Disease
43/100 ✓ Peer-reviewed Disease mechanisms International journal of molecular sciences
Key finding: Alzheimer's disease (AD) is one of the most common neurodegenerative disorders associated with age or inherited mutations. +1 more finding
Full summary, score breakdown and related studies → Original source
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2023-09-29
Sleep duration and brain MRI measures: Results from the SOL-INCA MRI study
57/100 ✓ Peer-reviewed Risk factors Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: The final analytic sample included n = 2334 participants. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-09-29
The role of Lactobacillus in inflammatory bowel disease: from actualities to prospects
43/100 ✓ Peer-reviewed Disease mechanisms Cell death discovery
Key finding: Inflammatory Bowel Disease (IBD), a chronic nonspecific intestinal inflammatory disease, is comprised of Ulcerative Colitis (UC) and Crohn's Disease (CD). +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-09-28
Air pollution, glymphatic impairment, and Alzheimer's disease
41/100 ✓ Peer-reviewed Risk factors Trends in neurosciences
Key finding: This opinion article examines the hypothesis that air pollution-induced impairment of glymphatic clearance represents a crucial etiological event in the development of AD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-09-28
Resting-State Functional Connectivity Difference in Alzheimer's Disease and Mild Cognitive Impairment Using Threshold-Free Cluster Enhancement
48/100 ✓ Peer-reviewed Brain scans and imaging Diagnostics (Basel, Switzerland)
Key finding: The study suggests that alterations in functional connectivity in these networks may contribute to cognitive deficits observed in AD and MCI. +1 more finding
Full summary, score breakdown and related studies → Original source
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2023-09-28
A multidomain intervention against cognitive decline in an at-risk-population in Germany: Results from the cluster-randomized AgeWell.de trial
81/100 ✓ Peer-reviewed Prevention trials Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: The intervention did not improve global cognitive performance. +1 more finding
Full summary, score breakdown and related studies → Original source
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2023-09-28
Personal Health Planning in Adult-Child Former Caregivers of Parents Living With Dementia
37/100 ✓ Peer-reviewed Health systems and care delivery American Journal of Health Promotion
Key finding: Caregiving for a parent living with dementia (PLWD) shapes former caregivers’ personal health planning. +1 more finding
Full summary, score breakdown and related studies → Original source
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2023-09-28
Addressing the Chronic Pain-Early Cognitive Decline Comorbidity Among Older Adults: Protocol for the Active Brains Remote Efficacy Trial
48/100 ✓ Peer-reviewed Treatments JMIR research protocols
Key finding: We are conducting a single-blinded, National Institutes of Health stage-2, randomized clinical trial to establish the efficacy of AB versus a time-matched and dose-matched education control (Health Enhancement Program [HEP]) in improving self-reported and objective outcomes of physical, cognitive, and emotional functions in 260 participants. +2 more findings
Full summary, score breakdown and related studies → Original source
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2023-09-27
Associations between multimorbidity burden and Alzheimer's pathology in older adults without dementia: the CABLE study
54/100 ✓ Peer-reviewed Tau biomarkers Neurobiology of aging
Key finding: Studies have shown that multimorbidity may be associated with the Alzheimer's disease (AD) stages, but it has not been fully characterized in patients without dementia. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-09-27
Utilization of P2Y12 Inhibitors in Older Adults With ST-Elevation Myocardial Infarction and Frailty
57/100 ✓ Peer-reviewed Health systems and care delivery The American journal of cardiology
Key finding: Choosing optimal P2Y12 inhibitor in frail older adults is challenging because they are at increased risk of both ischemic and bleeding events. +3 more findings
Full summary, score breakdown and related studies → Original source
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2023-09-25
Pathways explaining racial/ethnic and socio-economic disparities in dementia incidence: the UK Biobank study
59/100 ✓ Peer-reviewed Disparities Aging
Key finding: After ≤15 years, 5,491 all-cause dementia cases were diagnosed. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-09-25
Induction of proteasomal activity in mammalian cells by lifespan-extending tRNA synthetase inhibitors
43/100 ✓ Peer-reviewed Disease mechanisms GeroScience
Key finding: We have recently shown that multiple tRNA synthetase inhibitors can greatly increase lifespan in multiple models by acting through the conserved transcription factor ATF4.
Full summary, score breakdown and related studies → Original source
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2023-09-25
Monoclonal Antibody Treatments for Alzheimer's Disease: Aducanumab and Lecanemab
41/100 ✓ Peer-reviewed Treatments Discoveries (Craiova, Romania)
Key finding: In recent years, significant strides have been made in the development and subsequent clinical testing of disease-modifying therapies (DMTs) designed to potentially alter the underlying pathophysiology of AD.
Full summary, score breakdown and related studies → Original source
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2023-09-25
Sex difference in brain functional connectivity of hippocampus in Alzheimer's disease
50/100 ✓ Peer-reviewed Brain scans and imaging GeroScience
Key finding: Prior research has shown that AD disproportionality affects females; females have a greater incidence rate, perform worse on a variety of neuropsychological tasks, and have greater total brain atrophy. +3 more findings
Full summary, score breakdown and related studies → Original source
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2023-09-25
Plasma Aβ42/40 and cognitive variability are associated with cognitive function in Black Americans: Findings from the AA-FAIM cohort
70/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (New York, N. Y.)
Key finding: IICV was associated with concurrent/baseline performance on several outcomes but did not modify associations between age and cognitive decline. +3 more findings
Full summary, score breakdown and related studies → Original source
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