Newest studies

Role of glucagon-like peptide-1 receptor agonists in Alzheimer's disease and Parkinson's disease

45/100 ✓ Peer-reviewed Drug development Journal of biomedical science

Key finding: Various GLP-1RAs have been demonstrated to have significant benefits in in vitro and in vivo models of neurodegenerative diseases through modulating a variety of pathogenic mechanisms, including neuroinflammation, autophagy, mitochondrial dysfunction, and the abnormal phosphorylation of pathognomonic proteins. +1 more finding

• Treatments
• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Exploring geographic variations in quinoa grains: Unveiling anti-Alzheimer activity via GC–MS, LC-QTOF-MS/MS, molecular networking, and chemometric analysis

43/100 ✓ Peer-reviewed Risk factors Food Chemistry

Key finding: Quinoa is an ancient Andean crop with a significant interest due to its nutritional and health benefits. +1 more finding

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Chemical-Driven Amyloid Clearance for Therapeutics and Diagnostics of Alzheimer's Disease

40/100 ✓ Peer-reviewed Drug development Accounts of chemical research

Key finding: In a typical physiological state, the equilibrium of amyloid-β (Aβ) levels is maintained, but aging can precipitate disruptions in the homeostasis of Aβ due to its overproduction, impaired clearance, and other factors, ultimately leading to its accumulation. +3 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

The effects of mosaicism on biological and clinical markers of Alzheimer's disease in adults with Down syndrome

56/100 ✓ Peer-reviewed Down syndrome and Alzheimer's EBioMedicine

Key finding: For both cohorts, the prevalence of mosaicism was 40 and Aβ 42 concentrations. +1 more finding

• Down Syndrome
• Biomarkers

Full summary, score breakdown and related studies → Original source

Lumipulse-Measured Cerebrospinal Fluid Biomarkers for the Early Detection of Alzheimer Disease

45/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: The average age at LP was 79.3 years (SD = 5.6), and the average age at death was 87.1 years (SD = 6.5). +1 more finding

• Biomarkers

Full summary, score breakdown and related studies → Original source

Phenotype Scoring of Population Scale Single-Cell Data Dissects Alzheimer's Disease Complexity

16/100 ⚠ Preprint — not yet peer-reviewed Genetics medRxiv : the preprint server for health sciences

Key finding: Leveraging this dataset, we developed a deep learning framework, called Phenotype Associated Single Cell encoder (PASCode), to score single-cell phenotype associations, and identified ∼1.5 million phenotype associate cells (PACs). +4 more findings

Scored 22 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Home Health Care and Place of Death in Medicare Beneficiaries With and Without Dementia

46/100 ✓ Peer-reviewed End-of-life care The Gerontologist

Key finding: Receiving any home health care in the last 3 years of life was associated with a lower probability of inpatient death without hospice (Pr 23.3% vs 31.5%, p < .001), and this effect was stronger when home health care began prior to versus during the last year of life (Pr 22.5% vs 24.3%, p < .001). +3 more findings

• End-of-Life Care
• Care Services

Full summary, score breakdown and related studies → Original source

[Senses and dementia : sensory loss and dementia risk]

43/100 ✓ Peer-reviewed Risk factors Revue medicale de Liege

Key finding: In the course of several neurodegenerative conditions, the presence of a sensory alteration, even before the appearance of cognitive disorders or complaints concerning autonomy, can potentially lead to earlier diagnosis and more efficient management of these complex patients. +2 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Safety and efficacy of acetylcholinesterase inhibitors for Alzheimer's disease: A systematic review and meta-analysis

71/100 ✓ Peer-reviewed Treatments Advances in clinical and experimental medicine : official organ Wroclaw Medical University

Key finding: The standard mean difference (SMD) was -0.33 [-0.52, -0.13] for donepezil, -0.48 [-0.58, -0.38] for galantamine and -0.65 [-1.06, -0.23] for rivastigmine, indicating a significant effect of these drugs on cognitive outcomes. +1 more finding

• Treatments
• Side Effects

Full summary, score breakdown and related studies → Original source

Efficacy and Safety of GLP-1 Medicines for Type 2 Diabetes and Obesity

45/100 ✓ Peer-reviewed Drug development Diabetes care

Key finding: In ongoing trials investigators are interrogating the efficacy of these agents for new indications, including metabolic liver disease, peripheral artery disease, Parkinson disease, and Alzheimer disease. +4 more findings

• Risk Factors
• Side Effects

Full summary, score breakdown and related studies → Original source

The Italian guideline on diagnosis and treatment of dementia and mild cognitive impairment

45/100 ✓ Peer-reviewed End-of-life care Age and ageing

Key finding: Considering the significant impact of dementia, the Italian Ministry of Health entrusted the Italian National Institute of Health (Istituto Superiore di Sanità) with the development of a guideline within the Italian National Guideline System (Sistema Nazionale Linee Guida, SNLG) on the diagnosis and treatment of dementia and MCI. +2 more findings

• Treatments
• Diagnosis
• Early Stage

Full summary, score breakdown and related studies → Original source

Geospatial Analysis of the Association Between Medicaid Expansion, Minimum Wage Policies, and Alzheimer’s Disease Dementia Prevalence in the United States

45/100 ✓ Peer-reviewed Risk factors Information

Key finding: Previous studies indicate that increased healthcare access through Medicaid expansion and alleviation of socioeconomic stressors via higher minimum wages improved health outcomes. +4 more findings

• Policy
• Health Equity

Full summary, score breakdown and related studies → Original source

Demographics, comorbidities, and comedications in newly diagnosed patients with Alzheimer's disease and related dementias: Findings from United States Medicare claims data

48/100 ✓ Peer-reviewed Health systems and care delivery Journal of Alzheimer s Disease

Key finding: The newly diagnosed ADRD and new AChEI users cohorts included 861,727 and 395,319 patients, respectively. +4 more findings

• Policy

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Post-discharge Follow-up of Standardized Management for Patients with Post-stroke Cognitive Impairment

53/100 ✓ Peer-reviewed Health systems and care delivery Alternative therapies in health and medicine

Key finding: At baseline, no significant difference (P > .05) existed between the groups in the scores: (1) for cognitive function on the MMSE or MoCA, (2) for the physiological, psychological, social, and environmental domains and the total score on the WHOQOL-BREF, or (3) for self-efficacy on the GSES scores. +3 more findings

• Clinical Trials

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High-molecular-weight oligomer tau (HMWoTau) species are dramatically increased in Braak-stage dependent manner in the frontal lobe of human brains, demonstrated by a novel oligomer Tau ELISA with a mouse monoclonal antibody (APNmAb005)

40/100 ✓ Peer-reviewed Tau biomarkers FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Key finding: We developed a highly sensitive and selective ELISA for high-molecular-weight oligomer tau (HMWoTau) with LLOQ of 0.3 pg/well for the first time, using a novel mouse monoclonal antibody APNmAb005. +3 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Plasma Glial Fibrillary Acid Protein and Phosphorated Tau 181 Association with Presynaptic Density-Dependent Tau Pathology at 18F-SynVesT-1 Brain PET Imaging

47/100 ✓ Peer-reviewed Biomarkers Radiology

Key finding: Plasma p-tau-181 and GFAP are closely associated with synaptic density measured using 18 F-SynVesT-1 PET/MRI, with the relationship primarily influenced by tau accumulation rather than Aβ deposition or cortical thickness. © RSNA, 2024 Supplemental material is available for this article. +1 more finding

• Brain Scans
• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

Costs of Care in Relation to Alzheimer's Disease Severity in Sweden: A National Registry-Based Cohort Study

63/100 ✓ Peer-reviewed Costs and economics PharmacoEconomics

Key finding: Mean annual costs for individuals with clinically diagnosed AD were SEK 99,906, SEK 290,972, SEK 479,524, and SEK 795,617 in mild cognitive impairment (MCI), mild, moderate, and severe AD.

• Policy

Full summary, score breakdown and related studies → Original source

The efficacy of cognitive stimulation, cognitive training, and cognitive rehabilitation for people living with dementia: a systematic review and meta-analysis

59/100 ✓ Peer-reviewed Treatments GeroScience

Key finding: Cognitive rehabilitation appeared to be the most effective in improving caregivers' outcomes, with results suggesting a reduction in care burden.

• Lifestyle

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A Meta-analysis of Loneliness and Risk of Dementia using Longitudinal Data from >600,000 Individuals

81/100 ✓ Peer-reviewed Prevention and risk Nature Mental Health

Key finding: Loneliness was linked to a 31% higher risk of all-cause dementia (HR 1.306) +3 more findings

• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Air Pollution as an Environmental Risk Factor for Alzheimer's Disease and Related Dementias

43/100 ✓ Peer-reviewed Risk factors Medical research archives

Key finding: In addition to summarizing findings from epidemiological and experimental animal studies that link airborne exposures to environmental contaminants to increased risk and/or severity of Alzheimer's disease and related dementias, we discuss currently hypothesized mechanism(s) underlying these associations, including peripheral inflammation, neuroinflammation and epigenetic changes.

• Risk Factors

Full summary, score breakdown and related studies → Original source

Neuroprotective effects of GLP-1 receptor agonists in neurodegenerative Disorders: A Large-Scale Propensity-Matched cohort study

74/100 ✓ Peer-reviewed Drug development International immunopharmacology

Key finding: This study provides evidence that the effects of GLP-1 receptor agonists may extend beyond their known metabolic and cardioprotective benefits to include neuroprotection, associated with a decreased risk of developing various neurodegenerative disorders. +4 more findings

• Treatments
• Other Dementias
• Prevention

Full summary, score breakdown and related studies → Original source

Epileptic seizures induced by pentylenetetrazole kindling accelerate Alzheimer-like neuropathology in 5×FAD mice

38/100 ✓ Peer-reviewed Biomarkers Frontiers in pharmacology

Key finding: Clinical studies have shown that epileptic seizures worsen Alzheimer's disease (AD) pathology and related cognitive deficits; however, the underlying mechanism is unclear. +2 more findings

• Brain Biology
• Treatments

Full summary, score breakdown and related studies → Original source

UCB Presents Data on Bepranemab (anti-tau antibody) in Early Alzheimer's Disease: Phase 2a TOGETHER Study

16/100 ⚠ Press release — not a study Clinical trials UCB press release (data presented at CTAD 2024)

Key finding: Phase 2a, n=466, 80-week double-blind trial of low- and high-dose bepranemab vs placebo +2 more findings

• Clinical Trials

Scored 36 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Molecular Insights into Tau Pathology and its Therapeutic Strategies in Alzheimer's Disease

43/100 ✓ Peer-reviewed Drug development Journal of integrative neuroscience

Key finding: The plaques and tangles mainly consist of amyloid-β (Aβ) and tau protein, respectively. +4 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Single-cell transcriptomic and proteomic analysis of Parkinson's disease brains

43/100 ✓ Peer-reviewed Genetics Science translational medicine

Key finding: Parkinson's disease (PD) is a prevalent neurodegenerative disorder, and recent evidence suggests that pathogenesis may be in part mediated by inflammatory processes, the molecular and cellular architectures of which are largely unknown. +3 more findings

• Genetics
• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source