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33/100

✓ Peer-reviewed alzhub usefulness score 33 out of 100. Brain tissue and pathology

Topic: Amyloid, tau and blood-test diagnosis

Purpose of Review: Cerebral amyloid angiopathy (CAA) is a disease of the cerebral vasculature that can result in microhemorrhages, as well as intraparenchymal and subarachnoid hemorrhage, superficial siderosis (SS), and/or secondary infarct/inflammation. CAA may be encountered as an isolated pathology or with Alzheimer disease and has been demonstrated to be associated with an increased risk of seizures. However, the overall rates of seizures and specific pathologies related to CAA and their subsequent risk of seizures have not been elucidated. Recent findings: Prior studies of CAA and seizures are predominantly case reports or small case series, and larger studies have focused primarily on smaller subgroups of patients with CAA. Only 2 prior studies assessed larger heterogeneous populations of patients with CAA. One study focused on long-term outcomes and evaluated the impact of seizures on cognitive and survival outcomes retrospectively, although it did not delineate the effects of acute and chronic seizure disorders (epilepsy) and did not find an association. Long-term prospective or retrospective studies on outcomes regarding seizures/epilepsy and CAA are therefore lacking. Summary: = 0.002) were associated with seizures, likely related to inclusion of ASyS. Status epilepticus (14/125) and drug resistance (6/89) were infrequent. Clinical pathologic entities associated with a risk of seizures include cSAH, CAA-ri, SS, and acute ICH.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Freund, B. E., Shourav, M. M. I., Feyissa, A. M., Meschia, J. F., Yonas, A. S., Barrett, K. M., et al. (2025). Seizures in Cerebral Amyloid Angiopathy. Neurology Clinical Practice. https://doi.org/10.1212/cpj.0000000000200454

Vancouver

Freund BE, Shourav MMI, Feyissa AM, Meschia JF, Yonas AS, Barrett KM, et al. Seizures in Cerebral Amyloid Angiopathy. Neurology Clinical Practice. 2025. doi:10.1212/cpj.0000000000200454. PMID: 40161255.

BibTeX

@article{freund2025-40161255,
  author  = {Freund, Brin E. and Shourav, Md Manjurul Islam and Feyissa, Anteneh M. and Meschia, James F. and Yonas, Amen S. and Barrett, Kevin M. and Tatum, William O. and Lin, Michelle},
  title   = {{Seizures in Cerebral Amyloid Angiopathy}},
  journal = {Neurology Clinical Practice},
  year    = {2025},
  doi     = {10.1212/cpj.0000000000200454},
  pmid    = {40161255},
  url     = {https://doi.org/10.1212/cpj.0000000000200454}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

Key findings

Purpose of Review: Cerebral amyloid angiopathy (CAA) is a disease of the cerebral vasculature that can result in microhemorrhages, as well as intraparenchymal and subarachnoid hemorrhage, superficial siderosis (SS), and/or secondary infarct/inflammation.
CAA may be encountered as an isolated pathology or with Alzheimer disease and has been demonstrated to be associated with an increased risk of seizures.
However, the overall rates of seizures and specific pathologies related to CAA and their subsequent risk of seizures have not been elucidated.
Summary: = 0.002) were associated with seizures, likely related to inclusion of ASyS.
Clinical pathologic entities associated with a risk of seizures include cSAH, CAA-ri, SS, and acute ICH.

Why it matters

This review reports that cerebral amyloid angiopathy is associated with an increased risk of seizures, but notes that most prior studies were case reports or small series and that long-term prospective or retrospective studies on seizures and outcomes in this condition are lacking. It found that status epilepticus and drug resistance were infrequent in the cases examined.

Study details

Evidence strengthLow

How this study scored 33/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Neurology Clinical Practice)
Journal's citation record	0 / 4	Neurology Clinical Practice: journal h-index 60 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 2 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.7 citations a year over 3 year(s) since 2025
Impact for its field and year	2 / 6	Cited 1.1× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	1 / 4	Last-listed author Michelle Lin: h-index 15 (OpenAlex, whole career)
Institution's track record	2 / 3	Mayo Clinic: institution h-index 1,606 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 2 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40161255)
Free to read	2 / 2	Free to read
Total	33 / 100	—

What each of these 20 components measures, and what this score is not →

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Seizures in Cerebral Amyloid Angiopathy