Newest studies

Disease-modifying effects of TMEM106B in genetic frontotemporal dementia: a longitudinal GENFI study

63/100 ✓ Peer-reviewed Lewy body dementia Brain

Key finding: Common variants within TMEM106B are associated with risk for frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP). +3 more findings

• Other Dementias
• Genetics

Full summary, score breakdown and related studies → Original source

Knowledge and attitudes about dementia and dementia genetics in a cohort of geriatric clinic attendees in Nigeria

43/100 ✓ Peer-reviewed How common it is Journal of Alzheimer s Disease

Key finding: Attempts by participants to translate "dementia" in their local languages revealed misleading themes in their perception of the condition.

• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Comparative Evaluation of the Montreal Cognitive Assessment Basic Scale Against the Mini-Mental State Examination for Post-Stroke Cognitive Impairment

39/100 ✓ Peer-reviewed Getting a diagnosis ALPHA PSYCHIATRY

Key finding: Most factors of the MoCA-B were significantly different between the two groups, and the PSCN group completed the MoCA-B faster (p 0.05). +3 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Precision neurocognition: An emerging diagnostic paradigm leveraging digital cognitive assessment technology

41/100 ✓ Peer-reviewed Getting a diagnosis Journal of Alzheimer s Disease

Key finding: Recent research suggests that digital neuropsychological assessment technology may be the platform that can realize the goals of precision neurocognition, i.e., the early detection of neurocognitive difficulties that are prognostic for mild cognitive impairment (MCI) and dementia. +1 more finding

• Diagnosis
• Digital Tools

Full summary, score breakdown and related studies → Original source

Gut microbiota and associated metabolites: key players in high-fat diet-induced chronic diseases

46/100 ✓ Peer-reviewed Prevention and risk Gut Microbes

Key finding: Excessive intake of dietary fats is strongly associated with an increased risk of various chronic diseases, such as obesity, diabetes, hepatic metabolic disorders, cardiovascular disease, chronic intestinal inflammation, and certain cancers. +1 more finding

• Lifestyle
• Risk Factors

Full summary, score breakdown and related studies → Original source

APOE4 impairs macrophage lipophagy and promotes demyelination of spiral ganglion neurons in mouse cochleae

43/100 ✓ Peer-reviewed Genetics Cell death discovery

Key finding: The results showed that significant axonal demyelination was observed in SGNs of 10-month-old APOE4 mice, accompanied by the presence of myelin debris engulfed by RCMs. +1 more finding

• Brain Biology
• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Association between frailty and the progression trajectories of stroke and dementia comorbidity: insights from observational and genetic analyses

44/100 ✓ Peer-reviewed Vascular contributions Archives of Gerontology and Geriatrics

Key finding: The final analysis included 459,924 participants. +4 more findings

• Risk Factors

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The 3-Minute Diagnostic Confusion Assessment Method severity score correlates with the Delirium Rating Scale–Revised–98 and with biomarkers of delirium

50/100 ✓ Peer-reviewed Clinical safety BJA Open

Key finding: The 3D-CAM-S severity scores correlated with DRS, delirium duration, and biomarkers of delirium.

• Biomarkers
• Diagnosis

Full summary, score breakdown and related studies → Original source

Lewy Body Dementia Research in Latin America: A Scoping Review

47/100 ✓ Peer-reviewed Lewy body dementia Movement Disorders Clinical Practice

Key finding: Of the 1388 studies identified, 70 met the inclusion criteria for this review. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

EEG features associated with Alzheimer’s disease and Frontotemporal dementia are not reflected by processed indices used in anesthesia monitoring

48/100 ✓ Peer-reviewed Lewy body dementia Journal of Clinical Monitoring and Computing

Key finding: Spectral differences were pronounced, including a higher alpha/theta-ratio of controls (2.62 [95%CI: 1.54-3.62]) compared to both AD (0.55 [95%CI: 0.26-1.92], P < 0.001, AUC: 0.765 [0.642-0.888]) and FTD (0.83 [95%CI: 0.33-1.65], P = 0.007, AUC: 0.779 [0.652-0.907]). +3 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Prevalence of hearing loss in patients with dementia and its association with dementia severity

43/100 ✓ Peer-reviewed How common it is SAGE Open Medicine

Key finding: A total of 88 participants were included in the study. +4 more findings

• Risk Factors

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Abdominal obesity and the risk of young-onset dementia in women: a nationwide cohort study

51/100 ✓ Peer-reviewed How common it is Alzheimer s Research & Therapy

Key finding: Over a median follow-up of 8.2 years, YOD incidence increased progressively with higher WC. +4 more findings

• Risk Factors

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Alzheimer’s Disease Dementia Prevalence in the United States: A County-Level Spatial Machine Learning Analysis

42/100 ✓ Peer-reviewed Risk factors American Journal of Alzheimer s Disease & Other Dementias®

Key finding: Key findings showed that mobile homes were the most influential factor in 19.9% of U.S. counties, followed by NDVI (17.4%), physical inactivity (12.9%), households with no vehicle (11.3%), and particulate matter (10.4%), while other primary factors affecting <10% of U.S. counties.

• Risk Factors

Full summary, score breakdown and related studies → Original source

Blood pressure reduction and all-cause dementia in people with uncontrolled hypertension: an open-label, blinded-endpoint, cluster-randomized trial

82/100 ✓ Peer-reviewed Prevention and risk Nature Medicine

Key finding: Over 48 months, the net reduction in systolic BP was 22.0 mm Hg (95% confidence interval (CI) 20.6 to 23.4; P < 0.0001) and that in diastolic BP was 9.3 mm Hg (95% CI 8.7 to 10.0; P < 0.0001) in the intervention group compared to usual care. +2 more findings

• Clinical Trials
• Risk Factors

Full summary, score breakdown and related studies → Original source

Older adults living with Alzheimer’s Disease, dementia or mild cognitive impairment with no informal caregiver or care partner: IDEA Café, the first pilot randomized trial intervention for this underserved populations

56/100 ✓ Peer-reviewed Disparities Aging & Mental Health

Key finding: This study presents findings from IDEA Café, for older adults aged 50 and older living with early dementia, dementia, Alzheimer’s Disease or cognitive impairment (ED/CI) with no informal caregiver or care partner. +1 more finding

• Clinical Trials
• Caregiving
• Health Equity

Full summary, score breakdown and related studies → Original source

Combination of amyloid and FDG PET for the prediction of short-term conversion from MCI to Alzheimer´s disease in the clinical practice

45/100 ✓ Peer-reviewed Biomarkers European Journal of Nuclear Medicine and Molecular Imaging

Key finding: Amyloid-PET demonstrated high sensitivity (100% in year 1, 94.67% in year 4) and a high negative predictive value (100% in year 1, 88.24% in year 4). +4 more findings

• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Modified Cued Recall Test: Longitudinal Analysis of Test Versions and Item Recall in Adults With Down Syndrome

47/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of intellectual disability research : JIDR

Key finding: Demonstrated utility of the mCRT warrants further investigation into comparisons between the A and B versions, free versus cued recall and changes in performance over time to better understand sensitivity for tracking memory decline over time based on age and AD clinical status. +4 more findings

• Down Syndrome

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Cognitive and Neuropsychiatric Effects of 40 Hz tACS Simultaneously with Cognitive Exercises for Dementia: A Randomized, Crossover, Double-Blind, Sham-Controlled Study

49/100 ✓ Peer-reviewed Cognitive tests and assessment Medicina

Key finding: Real tACS paired with cognitive exercises significantly improved ADAS-Cog scores post-treatment compared to pre-treatment (p-value = 0.019), whereas sham tACS did not. +4 more findings

• Clinical Trials

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Left Ventricular Injury Detected by Cardiac MRI and Incident Ischemic Stroke and Dementia Risk

49/100 ✓ Peer-reviewed Vascular contributions Neurology

Key finding: LVI was significantly associated with incident ischemic stroke in the MI cohort (adjusted hazard ratio [HR] 1.82, 95% CI 1.08-3.09), but not in the CCA cohort. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

IGF-1 Provides Protective Role in Arteriosclerotic Cerebral Small Vessel Disease

42/100 ✓ Peer-reviewed Vascular contributions Hypertension

Key finding: Serum IGF-1 concentration was significantly reduced in patients and rats with arteriosclerotic cSVD. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Cluster Analysis of Palliative Care Patients’ Trajectories in Primary Care: Hospitalization Yes, but Home and Nursing Home Care Above All

33/100 ✓ Peer-reviewed End-of-life care Journal of Palliative Medicine

Key finding: Three hundred adult patients were included in the study. +4 more findings

• Care Services
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Primary Tauopathy With Logopenic/Semantic Mixed Progressive Aphasia and Frontotemporal Dementia-like Behavior

29/100 ✓ Peer-reviewed Disease mechanisms Cognitive and Behavioral Neurology

Key finding: Multimodal neuroimaging studies revealed underlying neuropathology indicative of primary tauopathy with presumable 3/4-repeat isoform, devoid of amyloid deposition. +1 more finding

• Other Dementias

Full summary, score breakdown and related studies → Original source

Shared Mechanisms of Blood-Brain Barrier Dysfunction and Neuroinflammation in Coronavirus Disease 2019 and Alzheimer Disease

42/100 ✓ Peer-reviewed Inflammation and the immune system American Journal Of Pathology

Key finding: Emerging evidence suggests that SARS-CoV-2 infection contributes to chronic neuroinflammation, a key driver in the etiopathogenesis of AD.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Nonlinear Associations of Accelerometer-Based Sedentary Time With Cognitive Functions in the UK Biobank

45/100 ✓ Peer-reviewed Long-term cohort studies The Journals of Gerontology Series B

Key finding: Except for the visual-spatial memory test, nonlinear approaches provided a better fit than linear methods to model the associations of sedentary time with other cognitive outcomes. +4 more findings

Full summary, score breakdown and related studies → Original source

Self- and Informant-Report Cognitive Decline Discordance and Mild Cognitive Impairment Diagnosis

56/100 ✓ Peer-reviewed Mild cognitive impairment JAMA Network Open

Key finding: ADNI participants (921 dyads) had a mean (SD) age of 71 (7) years and mean (SD) of 17 (3) years of education; 485 (53%) were female, 30 (3%) were Asian, 105 (11%) were Black, and 756 (82%) were White. eVAL participants (279 dyads) had a mean (SD) age of 71 (8) years and mean (SD) of 17 (2) years of education; 151 (54%) were female, 17 (6%) were Asian, 12 (4%) were Black, and 245 (88%) were White. +4 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source