Newest studies

Evaluation of Computer-Based Cognitive Training on Mild Cognitive Impairment in Parkinson’s Disease (PD-MCI): Α Review

41/100 ✓ Peer-reviewed Prevention trials Journal of Clinical Medicine

Key finding: Of the 747 studies identified, 6 studies fulfilled the eligibility criterion for this review. +3 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Neuroprotective Potential of Tetraselmis chuii Compounds: Insights into Blood–Brain Barrier Permeability and Intestinal Transport

41/100 ✓ Peer-reviewed Disease mechanisms Pharmaceuticals

Key finding: The results showed that T. chuii extracts could protect neuronal cells from neurotoxic damage, especially against L-glutamate and H2O2. +3 more findings

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TDP-43 seeding activity in the olfactory mucosa of patients with amyotrophic lateral sclerosis

46/100 ✓ Peer-reviewed Brain tissue and pathology Molecular Neurodegeneration

Key finding: TDP-43_SAA was positive in 29/65 patients with sporadic MND, 9/21 patients with genetic MND, 6/17 OND patients and 3/22 controls. +4 more findings

• Brain Biology
• Biomarkers

Full summary, score breakdown and related studies → Original source

Presenilin 1 M139I mutation regulates the microRNA-34a-mediated neurogenic locus notch homolog protein 1 signaling pathway in an early-onset Alzheimer disease cell model

30/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of Neuropathology & Experimental Neurology

Key finding: A recent study found that the PSEN1 M139I mutation is associated with EOAD. +2 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Delirium in the emergency department: Incidence and risk factors in a Ligurian hospital

41/100 ✓ Peer-reviewed Risk factors Archives of Gerontology and Geriatrics Plus

Key finding: Significant associations were found between delirium and age ( p = 0.0025), antipsychotic use ( p < 0.0001), CFS score ( p = 0.014), and number of medications at admission ( p = 0.009). +1 more finding

• Risk Factors
• Care Services

Full summary, score breakdown and related studies → Original source

Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learning

51/100 ✓ Peer-reviewed Digital health tools GeroScience

Key finding: AD dementia, n = 568) and two longitudinal binary-class classifications (CN-to-MCI converters vs. +4 more findings

• Early Stage
• Digital Tools

Full summary, score breakdown and related studies → Original source

Disparities in Clinical Trial Participation for Hearing Loss Treatment and Cognitive Outcomes in the United States: A Scoping Review

40/100 ✓ Peer-reviewed Disparities The Laryngoscope

Key finding: Twenty-two studies (RCTs, non-RCTs, single arm and prospective trials) were included (n = 6-977; mean age: 72.0 years; 66.9% male). +4 more findings

• Health Equity
• Clinical Trials
• Risk Factors

Full summary, score breakdown and related studies → Original source

Prediction of dementia risk by instrumental activities of daily living limitations and its impact on dementia onset in combination with mild cognitive impairment: a population-based longitudinal study

59/100 ✓ Peer-reviewed Long-term cohort studies BMC Public Health

Key finding: Among all participants, 247 (11.7%) had IADL limitations at baseline, and 151 (7.1%) developed dementia during follow-up. +4 more findings

• Risk Factors
• Early Stage

Full summary, score breakdown and related studies → Original source

Neuropsychiatric symptoms and progression to pathologically confirmed Alzheimer’s disease

60/100 ✓ Peer-reviewed Mild cognitive impairment Brain

Key finding: Whether or not neuropsychiatric symptoms (NPS) in advance of dementia are associated with Alzheimer's disease (AD) and/or other neurodegenerative dementias remains to be determined. +4 more findings

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Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing

75/100 ✓ Peer-reviewed Risk factors Nature Communications

Key finding: We confirm UNC13A as the strongest overall FTLD-TDP risk factor and identify TNIP1 as a novel FTLD-TDP risk factor. +2 more findings

• Genetics
• Risk Factors
• Other Dementias

Full summary, score breakdown and related studies → Original source

Landscapes of care for dementia in rural South Africa

35/100 ✓ Peer-reviewed Disparities Journal of Rural Studies

Key finding: Faced with an increasing need for someone to consistently watch over Nonisa and ensure her safety, her family unsuccessfully sought access to a government grant to pay a caregiver. +4 more findings

• Health Equity
• Caregiving

Full summary, score breakdown and related studies → Original source

Use of dietary supplements by individuals with dementia - the caregivers’ perspective

42/100 ✓ Peer-reviewed Caregiving Scandinavian Journal of Primary Health Care

Key finding: Out of 163 caregivers invited to participate, 104 (64%) participated. +4 more findings

• Caregiving
• Lifestyle

Full summary, score breakdown and related studies → Original source

Environment, lifestyle, and cancer in women

43/100 ✓ Peer-reviewed Prevention and risk International Journal of Gynecology & Obstetrics

Key finding: Environmental and lifestyle factors significantly contribute to gynecological cancers. +2 more findings

• Prevention
• Lifestyle
• Genetics

Full summary, score breakdown and related studies → Original source

Cancer risk according to lifestyle risk score trajectories: a population-based cohort study

38/100 ✓ Peer-reviewed Prevention and risk BJC Reports

Key finding: During the follow-up time (2008-2019), 312,075 cancer cases were identified. +3 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

Combined mind-body physical exercise, cognitive training, and nurse-led risk factor modification to enhance cognition among older adults with mild cognitive impairment in primary care: a three-arm randomised controlled trial

64/100 ✓ Peer-reviewed Prevention and risk The Lancet Healthy Longevity

Key finding: No significant difference between the three groups in ADAS-Cog was found at the primary endpoint at 15 months (CPR vs health advice, β= -0·04 [95% CI -0·34 to 0·26]; RFM vs health advice, β= -0·14 [-0·44 to 0·15]; CPR vs RFM, β=0·10 [-0·19 to 0·40]) nor at the 6-month and 12-month follow-ups.

• Clinical Trials
• Lifestyle

Full summary, score breakdown and related studies → Original source

Curcumin Modulation of the Gut-Brain Axis for Neuroinflammation and Metabolic Disorders Prevention and Treatment

43/100 ✓ Peer-reviewed Disease mechanisms Nutrients

Key finding: Curcumin, a polyphenolic compound derived from Curcuma longa, has gained significant attention for its potential therapeutic benefits, particularly counteracting inflammation, oxidative stress, and metabolic disorders. +2 more findings

• Brain Biology
• Treatments

Full summary, score breakdown and related studies → Original source

Linking Metabolic Syndrome to Neurodegeneration Mechanisms and Potential Treatments

59/100 ✓ Peer-reviewed Risk factors Molecular neurobiology

Key finding: MetS affects approximately 25% of the global adult population and is associated with insulin resistance, hypertension, dyslipidemia, and obesity, factors increasingly linked to cognitive impairment and brain atrophy.

• Treatments
• Risk Factors
• Brain Biology

Full summary, score breakdown and related studies → Original source

Amyloid-Related Imaging Abnormality (ARIA) Beyond the APOE-ε4 Allele

43/100 ✓ Peer-reviewed Treatments Chronic diseases and translational medicine

Key finding: Monoclonal antibodies (mAbs) have made significant progress in the treatment of Alzheimer's disease (AD). +2 more findings

• Side Effects
• Genetics
• Treatments

Full summary, score breakdown and related studies → Original source

Exploring emotion recognition in patients with mild cognitive impairment and Alzheimer’s dementia undergoing a rehabilitation program

41/100 ✓ Peer-reviewed Prevention trials PLoS ONE

Key finding: Emotion scores for fear and surprise were significantly higher for the AD group than for the MCI group during dual tasks (p=0.016), while emotion scores for joy were significantly higher for the MCI group than for the AD group during creative activities (p=0.012). +3 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Anti-inflammatory effects of 64Zn-aspartate is accompanied by cognitive improvements in rats with Aβ1-40-induced alzheimer disease

37/100 ✓ Peer-reviewed Inflammation and the immune system Scientific Reports

Key finding: In rats with Aβ 1-40 -induced AD, persistent systemic inflammation was also registered, as was ascertained by significantly increased white blood cell-based inflammatory indices and development of anemia of inflammation. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

"Transformative Approaches to Alzheimer Disease Treatment: Current Progress and Future Direction”

27/100 ✓ Peer-reviewed Risk genes beyond APOE Communications on Applied Nonlinear Analysis

Key finding: Current medications mostly address symptoms, despite significant research advancement, leaving a demand for disease-modifying therapy unfulfilled. +1 more finding

• Treatments
• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Detection of Alzheimer and mild cognitive impairment patients by Poincare and Entropy methods based on electroencephalography signals

36/100 ✓ Peer-reviewed Mild cognitive impairment BioMedical Engineering OnLine

Key finding: Alzheimer's disease (AD) is characterized by deficits in cognition, behavior, and intellectual functioning, and Mild Cognitive Impairment (MCI) refers to individuals whose cognitive impairment deviates from what is expected for their age but does not significantly interfere with daily activities. +1 more finding

• Early Stage

Full summary, score breakdown and related studies → Original source

UTI risk factors in older people living with dementia: A conceptual framework and a scoping review

42/100 ✓ Peer-reviewed Risk factors Dementia

Key finding: The literature review scrutinized 1394 articles, selecting 14 through rigorous evaluation. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Perspectives of Former Caregivers of Black Older Adults Living With Dementia on Advance Care Planning

31/100 ✓ Peer-reviewed Disparities Journal of Gerontological Nursing

Key finding: Future research should leverage perspectives of former caregivers to assist with improving outcomes for Black caregivers, thereby promoting health equity. [ Journal of Gerontological Nursing, 51 (6), 30–37.]

• Health Equity
• Caregiving
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Hypertensive disorders of pregnancy and neuroimaging markers of dementia risk: A pilot study

53/100 ✓ Peer-reviewed Disparities Pregnancy

Key finding: Midlife individuals who experienced HDP had lower regional CBF and reduced white matter microstructural integrity, compared with those with no adverse pregnancy outcomes. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source