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Combined mind-body physical exercise, cognitive training, and nurse-led risk factor modification to enhance cognition among older adults with mild cognitive impairment in primary care: a three-arm randomised controlled trial
Xu Z, Zhang D, Yip BH, Lee EK, Poon PK, Peters R, Yang Z, Lee AT, Leung MK, Wong EL, et al.. The Lancet Healthy Longevity, 2025-04-25
Topic: Risk, prevention and care in population studies
No significant difference between the three groups in ADAS-Cog was found at the primary endpoint at 15 months (CPR vs health advice, β= -0·04 [95% CI -0·34 to 0·26]; RFM vs health advice, β= -0·14 [-0·44 to 0·15]; CPR vs RFM, β=0·10 [-0·19 to 0·40]) nor at the 6-month and 12-month follow-ups.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Xu, Z., Zhang, D., Yip, B. H., Lee, E. K., Poon, P. K., Peters, R., et al. (2025). Combined mind-body physical exercise, cognitive training, and nurse-led risk factor modification to enhance cognition among older adults with mild cognitive impairment in primary care: a three-arm randomised controlled trial. The Lancet Healthy Longevity. https://doi.org/10.1016/j.lanhl.2025.100706
Vancouver
Xu Z, Zhang D, Yip BH, Lee EK, Poon PK, Peters R, et al. Combined mind-body physical exercise, cognitive training, and nurse-led risk factor modification to enhance cognition among older adults with mild cognitive impairment in primary care: a three-arm randomised controlled trial. The Lancet Healthy Longevity. 2025. doi:10.1016/j.lanhl.2025.100706. PMID: 40294622.
BibTeX
@article{xu2025-40294622,
author = {Xu, Z. and Zhang, D. and Yip, B. H. and Lee, E. K. and Poon, P. K. and Peters, R. and Yang, Z. and Lee, A. T. and Leung, M. K. and Wong, E. L. and others},
title = {{Combined mind-body physical exercise, cognitive training, and nurse-led risk factor modification to enhance cognition among older adults with mild cognitive impairment in primary care: a three-arm randomised controlled trial}},
journal = {The Lancet Healthy Longevity},
year = {2025},
doi = {10.1016/j.lanhl.2025.100706},
pmid = {40294622},
url = {https://doi.org/10.1016/j.lanhl.2025.100706}
}
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Key findings
- No significant difference between the three groups in ADAS-Cog was found at the primary endpoint at 15 months (CPR vs health advice, β= -0·04 [95% CI -0·34 to 0·26]; RFM vs health advice, β= -0·14 [-0·44 to 0·15]; CPR vs RFM, β=0·10 [-0·19 to 0·40]) nor at the 6-month and 12-month follow-ups.
Why it matters
This three-arm trial found no significant difference in cognition between combined mind-body exercise, cognitive training and risk factor modification, risk factor modification alone, and health advice at 15 months or at earlier follow-ups. The interventions tested did not clearly improve cognition in people with mild cognitive impairment.
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Study details
- Study designRCT
- Participants456
- Effect sizeADAS-Cog z-score difference vs health advice: -0.04 (95% CI -0.34 to 0.26) for combined package
- Evidence strengthNull-result
Limitations
Single clinic in Hong Kong; active components delivered for only 3 months; open-label; participants on average had relatively mild impairment and were a self-selected group who applied to join.
How this study scored 64/100
Published in a leading specialty journal, and it is a randomised controlled trial. We have no data on free to read, so that was left out: it earned 63 of the 98 points we could judge it on, which is 64 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (The Lancet Healthy Longevity) |
| Journal's citation record | 1 / 4 | The Lancet Healthy Longevity: journal h-index 78 (OpenAlex, 2026-10-29) |
| Study design | 11 / 12 | A randomised controlled trial |
| Strength of evidence | 3 / 5 | Rated “null-result” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 456 participants |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 1 / 2 | Randomised (as stated in the record) |
| Times cited | 2 / 7 | Cited 9 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 3.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 3 / 6 | Cited 5.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 9 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Samuel Yeung Shan Wong: h-index 72 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | UNSW Sydney: institution h-index 1,101 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40294622) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 63 / 98 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 63 of the 98 points we could judge it on is 64 out of 100. |
| Total | 64 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.
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