Home › Research › Inflammation and the immune system
Anti-inflammatory effects of 64Zn-aspartate is accompanied by cognitive improvements in rats with Aβ1-40-induced alzheimer disease
Max Temnik, Mariia P. Rudyk, А. А. Балакин, Sergey Gurin, Taisa Dovbynchuk, Roman Byshovets, Natalia Dziubenko, Ganna M. Tolstanova et al.. Scientific Reports, 2025-04-24
Topic: Amyloid, tau and blood-test diagnosis
Alzheimer disease (AD) is a debilitating progressive dementia, whose pathophysiology is not fully understood. Chronic inflammation is now widely accepted as one of the key features of AD pathogenesis. Because of this, anti-inflammatory preparations are considered as putative disease modifying agents. A new compound of zinc aspartate with enriched light atoms 64 Zn ( 64 Zn-asp) was evaluated as a possible anti-AD agent using Aβ 1-40 -induced AD model. Intrahippocampal Aβ 1-40 injection resulted in pronounced neuroinflammation, as was evidenced by increased phagocytic activity, augmented reactive oxygen species generation, and up-regulated CD86 and CD206 expression by microglia. In rats with Aβ 1-40 -induced AD, persistent systemic inflammation was also registered, as was ascertained by significantly increased white blood cell-based inflammatory indices and development of anemia of inflammation. Neuro- and systemic inflammation in rats was accompanied by hippocampal dopamine neuron loss, as well as by impairment of short-term and remote spatial memory and cognitive flexibility. Intravenous 64 Zn-asp administration rats with AD was associated with returning all microglia indicators to normal range. All aforementioned features of systemic inflammation were not observed in these animals. Anti-inflammatory 64 Zn-asp effect was strongly correlated with improvement of short-term spatial memory and cognitive flexibility, and moderately—with betterment of remote spatial memory. These results demonstrated that i.v. 64 Zn-asp administration could reverse the inflammatory and, as a result, cognitive effects of intra-hippocampal Aβ 1-40 in rats. Therefore, its use may be a viable approach in the complex therapeutic strategy for AD.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Temnik, M., Rudyk, M. P., Балакин, А. А., Gurin, S., Dovbynchuk, T., Byshovets, R., et al. (2025). Anti-inflammatory effects of 64Zn-aspartate is accompanied by cognitive improvements in rats with Aβ1-40-induced alzheimer disease. Scientific Reports. https://doi.org/10.1038/s41598-025-97830-6
Vancouver
Temnik M, Rudyk MP, Балакин АА, Gurin S, Dovbynchuk T, Byshovets R, et al. Anti-inflammatory effects of 64Zn-aspartate is accompanied by cognitive improvements in rats with Aβ1-40-induced alzheimer disease. Scientific Reports. 2025. doi:10.1038/s41598-025-97830-6. PMID: 40274975.
BibTeX
@article{temnik2025-40274975,
author = {Temnik, Max and Rudyk, Mariia P. and Балакин, А. А. and Gurin, Sergey and Dovbynchuk, Taisa and Byshovets, Roman and Dziubenko, Natalia and Tolstanova, Ganna M. and others},
title = {{Anti-inflammatory effects of 64Zn-aspartate is accompanied by cognitive improvements in rats with Aβ1-40-induced alzheimer disease}},
journal = {Scientific Reports},
year = {2025},
doi = {10.1038/s41598-025-97830-6},
pmid = {40274975},
url = {https://doi.org/10.1038/s41598-025-97830-6}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- In rats with Aβ 1-40 -induced AD, persistent systemic inflammation was also registered, as was ascertained by significantly increased white blood cell-based inflammatory indices and development of anemia of inflammation.
- Intravenous 64 Zn-asp administration rats with AD was associated with returning all microglia indicators to normal range.
- These results demonstrated that i.v. 64 Zn-asp administration could reverse the inflammatory and, as a result, cognitive effects of intra-hippocampal Aβ 1-40 in rats.
Why it matters
In rats with amyloid-beta-induced Alzheimer's-like disease, intravenous 64Zn-aspartate returned microglia indicators to normal and reversed inflammatory and cognitive effects. This is animal research, so it does not yet show benefit for treating Alzheimer's disease in people.
Study details
- Evidence strengthLow
How this study scored 37/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Scientific Reports) |
| Journal's citation record | 3 / 4 | Scientific Reports: journal h-index 463 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Laboratory or animal study (title names “rats”) — scores zero |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 5 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 2.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 5 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Larysa M. Skivka: h-index 10 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Taras Shevchenko National University of Kyiv: institution h-index 188 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40274975) |
| Free to read | 2 / 2 | Free to read |
| Total | 37 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1038/s41598-025-97830-6
- PubMed: 40274975
- Original source →
- Free full text: Scientific Reports →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Related
Studies in the library that share something with this one. The line above each title says what.
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.
Related studies in Inflammation and the immune system
Also tagged “placebo-controlled”
783 studies in the library carry the topic tag “placebo-controlled”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 783 tagged studies.